INT11033

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 15.75
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MUC16) extracellular region (MUC16) cell adhesion (MUC16)
plasma membrane (MUC16)
Anatomy Link Frequency
tear 6
eye 2
pleural fluid 2
uterus 2
biliary tract 2
MUC16 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 10 99.18 Very High Very High Very High
Dismenorea 7 99.00 Very High Very High Very High
Thoracotomy 1 98.80 Very High Very High Very High
endometriosis 38 98.32 Very High Very High Very High
Angina 1 95.72 Very High Very High Very High
pain pelvic 1 89.08 High High
Inflammation 9 89.00 High High
Chronic pancreatitis 1 86.28 High High
imagery 11 77.48 Quite High
agonist 5 67.12 Quite High
Disease Link Frequency Relevance Heat
Ovarian Cancer 384 100.00 Very High Very High Very High
Syndrome 346 99.98 Very High Very High Very High
Pleural Effusion 1 99.96 Very High Very High Very High
Pressure And Volume Under Development 33 99.66 Very High Very High Very High
Dry Eye 163 99.58 Very High Very High Very High
Abdominal Pain 10 99.18 Very High Very High Very High
Sjoegrens Syndrome 161 99.08 Very High Very High Very High
Disease 180 99.00 Very High Very High Very High
Dysmenorrhea 4 99.00 Very High Very High Very High
Vomiting 9 98.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose that conjunctival cells in Sjogren’s syndrome increase their production of MUC16 as a compensatory mechanism to maintain their healthy phenotype.



Positive_regulation (increase) of Gene_expression (production) of MUC16 associated with syndrome
1) Confidence 0.69 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.78 Pain Relevance 0
We found that Sjogren’s subjects express significantly elevated concentrations of both soluble MUC16 and MUC16 mRNA compared to both KCS and NDE groups.
Positive_regulation (concentrations) of Gene_expression (express) of MUC16 associated with sjoegrens syndrome and eye disease
2) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.86 Pain Relevance 0
Since our results demonstrated no correlation between tear flow and MUC16 concentration, we believe that it is the unique nature of autoimmune related dry eye that influences the stimulus for MUC16 expression.
Positive_regulation (stimulus) of Gene_expression (expression) of MUC16 in tear associated with dry eye
3) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.77 Pain Relevance 0
Although we did not stain the ocular surface of the subjects at the time of their visit for tear and cell collection in this study, our results suggest that staining scores, at least in SS patients, would not correlate with a reduction in membrane MUC16, as we found no differences in membrane bound MUC16 expression in any of our subject groups.
Positive_regulation (bound) of Gene_expression (expression) of MUC16 in tear associated with syndrome
4) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.61 Pain Relevance 0
CA 125 levels during menstruation were significantly elevated, not only in women with adenomyosis and advanced endometriosis, but also in those with mild endometriosis, compared with those with a normal pelvis.
Positive_regulation (elevated) of Gene_expression (levels) of CA 125 in pelvis associated with endometriosis and dismenorea
5) Confidence 0.49 Published 1988 Journal Obstet Gynecol Section Abstract Doc Link 3165507 Disease Relevance 0.73 Pain Relevance 0.46
Patients with normal serum CA125 levels after 3 months (strata 1 and 2) had increased survival compared to patients with high serum CA125 levels at 3 months (strata 3 and 4).
Positive_regulation (increased) of Gene_expression (levels) of CA125
6) Confidence 0.48 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.19 Pain Relevance 0
The results of this study demonstrate that subjects with confirmed Sjogren’s Syndrome display a significant increase in MUC16 expression, as the concentrations of both MUC16 soluble protein and mRNA were found to be higher than those of aqueous deficient dry eye subjects (KCS) and subjects with no dry eye disease (NDE).
Positive_regulation (increase) of Gene_expression (expression) of MUC16 in eye associated with sjoegrens syndrome, syndrome, dry eye and eye disease
7) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.10 Pain Relevance 0
This study was based on the hypothesis that uterine myomata would distend the peritoneum covering the uterus and thereby increase the peripheral levels of CA 125.
Positive_regulation (increase) of Gene_expression (levels) of CA 125 in uterus
8) Confidence 0.45 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1532397 Disease Relevance 0.58 Pain Relevance 0.18
[Increased levels of Ca 19-9, Ca 50 and Ca 125 in patients with benign diseases of the biliary tract and the pancreas].
Positive_regulation (Increased) of Gene_expression (levels) of Ca 125 in biliary tract associated with disease
9) Confidence 0.45 Published 1990 Journal J. Nucl. Med. Allied Sci. Section Title Doc Link 2092159 Disease Relevance 0.91 Pain Relevance 0.09
The authors report on a case of Meigs' syndrome in a patient admitted with vomiting, abdominal pain, peritoneal and right pleural effusion, increased serum levels of CA 125.
Positive_regulation (increased) of Gene_expression (levels) of CA 125 associated with pleural effusion, abdominal pain, syndrome and vomiting
10) Confidence 0.45 Published 1996 Journal G Chir Section Abstract Doc Link 8754555 Disease Relevance 0.47 Pain Relevance 0.10
The serum and pleural fluid levels of carcinoembryonic antigens, CA-125 and CA19-9 were invariably elevated, then decreased to normal range after the surgical resection.
Positive_regulation (elevated) of Gene_expression (levels) of CA-125 in pleural fluid
11) Confidence 0.45 Published 2001 Journal Pediatr Hematol Oncol Section Abstract Doc Link 11293292 Disease Relevance 0.62 Pain Relevance 0.15
Increased association of elevated levels of CA 125 and CA 15-3 is not so common in advanced endometriosis.
Positive_regulation (elevated) of Gene_expression (levels) of CA 125 associated with endometriosis
12) Confidence 0.45 Published 2008 Journal Clin Exp Obstet Gynecol Section Abstract Doc Link 18754302 Disease Relevance 0.64 Pain Relevance 0.22
Moreover, this patient had elevated serum levels of CA-125, which has been established as a useful marker for determining the severity of endometriosis [17,18].
Positive_regulation (elevated) of Gene_expression (levels) of CA-125 associated with endometriosis
13) Confidence 0.45 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC184504 Disease Relevance 1.32 Pain Relevance 0.54
In women with clinically detected stage I EOC (of various histologies), pre-operative serum levels of CA125 are elevated (>35 U/ml) in roughly 66% of women [8].
Positive_regulation (elevated) of Gene_expression (levels) of CA125 associated with ovarian cancer
14) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 0.85 Pain Relevance 0.04
Mechanistically, albeit simplistically, it appears that increased expression of mRNAs coding for MUC1 and MUC16 are followed by excess shedding of these species into the tear film, or vice versa.
Positive_regulation (increased) of Gene_expression (expression) of MUC16 in tear
15) Confidence 0.42 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.61 Pain Relevance 0.03
We found that patients with an improved CA125 levels 3 months had a significantly better survival than those with deteriorated CA125 levels at 3 months.
Positive_regulation (improved) of Gene_expression (levels) of CA125
16) Confidence 0.42 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.56 Pain Relevance 0
The isolated ascites cells were also positive for CA-125 expression as was tested by immunohistochemistry (IHC) analysis (data not shown).
Positive_regulation (positive) of Gene_expression (expression) of CA-125 associated with pressure and volume under development
17) Confidence 0.19 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 1.15 Pain Relevance 0.09
In the 21 patients available for analysis, response was documented in 14.3% of cases according to the RECIST criteria, and in 8 out of 14 cases (57.1%) who had elevated Ca125 levels at enrolment.
Positive_regulation (elevated) of Gene_expression (levels) of Ca125
18) Confidence 0.09 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952486 Disease Relevance 0.37 Pain Relevance 0
RESULTS: The receiver operating characteristic curve showed the best cut-off values of the NLR (>or=2.12) and serum CA-125 levels (>or=27.5U/ml) for the preoperative diagnosis of uterine sarcomas, demonstrating that the NLR was more powerful for the preoperative diagnosis of uterine sarcomas than serum CA-125 levels (sensitivity, 74.5% vs. 52.3%; specificity, 70.3% vs. 50.5%; positive predictive value, 29.5% vs. 15.1%; negative predictive value, 94.3% vs. 86.5%; accuracy, 60.6% vs. 49.6%; p<0.05).
Positive_regulation (values) of Gene_expression (levels) of CA-125 in uterine
19) Confidence 0.07 Published 2010 Journal Eur J Surg Oncol Section Body Doc Link 20570475 Disease Relevance 0.08 Pain Relevance 0
A related observation is that serum CA125 levels are elevated in 80% of patients with advanced stage epithelial ovarian carcinoma but are increased in only 60% of patients with early stage disease [27,28].
Positive_regulation (elevated) of Gene_expression (levels) of CA125 associated with ovarian cancer and disease
20) Confidence 0.03 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2592352 Disease Relevance 1.14 Pain Relevance 0

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