INT110333

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.18
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
spinal cord 2
oocytes 2
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 17 100.00 Very High Very High Very High
Inflammation 8 99.98 Very High Very High Very High
Dorsal horn 1 99.68 Very High Very High Very High
Spinal cord 6 98.92 Very High Very High Very High
Action potential 2 96.56 Very High Very High Very High
Hyperalgesia 2 95.80 Very High Very High Very High
IPN 2 95.40 Very High Very High Very High
antagonist 4 89.04 High High
intrathecal 1 88.72 High High
Glutamate receptor 2 88.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.98 Very High Very High Very High
Epilepsy 22 97.84 Very High Very High Very High
Hyperalgesia 2 95.80 Very High Very High Very High
Inflammatory Pain 3 95.40 Very High Very High Very High
Hypersensitivity 2 94.68 High High
Hypoxia 10 90.72 High High
Malformations Of Cortical Development 1 88.32 High High
Cv Unclassified Under Development 2 86.12 High High
Injury 10 79.24 Quite High
Convulsion 30 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results indicate that peripheral inflammation induces downregulation of KCC2 in the dorsal horn of the spinal cord, which may in turn facilitate the development and/or maintenance of chronic inflammatory pain.
Positive_regulation (induces) of Negative_regulation (downregulation) of KCC2 in spinal cord associated with inflammation, ipn, dorsal horn and spinal cord
1) Confidence 0.50 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 1.05 Pain Relevance 1.13
Inhibition of the K-Cl cotransporter (KCC) (furosemide 100 microm) together with TTX was also more effective than TTX alone (84 +/- 14%).
Positive_regulation (effective) of Negative_regulation (Inhibition) of K-Cl cotransporter associated with tetrodotoxin
2) Confidence 0.49 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736353 Disease Relevance 0.58 Pain Relevance 0.73
Inhibition of the K-Cl cotransporter (KCC) (furosemide 100 microm) together with TTX was also more effective than TTX alone (84 +/- 14%).
Positive_regulation (effective) of Negative_regulation (Inhibition) of KCC associated with tetrodotoxin
3) Confidence 0.49 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736353 Disease Relevance 0.58 Pain Relevance 0.73
Palma et al. independently concluded that cell membranes from human epileptic tissue, when injected into Xenopus oocytes, elicited depolarizing GABAAergic currents, which was linked to upregulation of NKCC1 and downregulation of KCC2 [237].
Positive_regulation (upregulation) of Negative_regulation (downregulation) of KCC2 in oocytes associated with epilepsy
4) Confidence 0.34 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.98 Pain Relevance 0.19

General Comments

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