INT110389

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.13
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1d) signal transducer activity (Htr1d)
Anatomy Link Frequency
nerve 1
Htr1d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 21 100.00 Very High Very High Very High
GABAergic 54 99.84 Very High Very High Very High
Serotonin 6 99.72 Very High Very High Very High
Periaqueductal grey 110 98.36 Very High Very High Very High
Sumatriptan 86 98.36 Very High Very High Very High
Neurotransmitter 11 97.74 Very High Very High Very High
antagonist 26 96.04 Very High Very High Very High
Ventral tegmentum 2 92.76 High High
agonist 28 87.76 High High
opioid receptor 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Appetite Loss 1 99.14 Very High Very High Very High
Urological Neuroanatomy 110 98.36 Very High Very High Very High
Eating Disorder 12 96.88 Very High Very High Very High
Reprotox - General 1 1 56.32 Quite High
Pain 18 41.20 Quite Low
Headache 20 25.36 Quite Low
Nociception 4 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low
Photophobia 2 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also examined the contribution of 5-HT1B and 5-HT1D receptors to the inhibition produced by sumatriptan by pre-incubating slices in 5-HT1B and 5-HT1D antagonists.
Spec (examined) Regulation (contribution) of 5-HT1D associated with sumatriptan and antagonist
1) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.07 Pain Relevance 0.93
The present study has demonstrated that functional 5-HT1A, 5-HT1B and 5-HT1D receptors are present on GABAergic nerve terminals within the PAG.
Regulation (present) of 5-HT1D in nerve associated with periaqueductal grey and gabaergic
2) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.37 Pain Relevance 1.06
Serotonergic and opioidergic neurotransmitter system alterations have been observed in people with eating disorders; the genes for the serotonin 1D receptor (HTR1D) and the opioid delta receptor (OPRD1) are found on chr1p36.3-34.3, a region identified by our group in a linkage analysis of anorexia nervosa (AN).
Regulation (found) of HTR1D associated with appetite loss, neurotransmitter, opioid, serotonin and eating disorder
3) Confidence 0.37 Published 2003 Journal Mol. Psychiatry Section Abstract Doc Link 12740597 Disease Relevance 0.69 Pain Relevance 0.27

General Comments

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