INT11042

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Context Info
Confidence 0.76
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 29
Disease Relevance 10.15
Pain Relevance 7.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 9
coronary artery 2
plasma 1
aorta 1
liver 1
Tbxa2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 9 100.00 Very High Very High Very High
5HT 2 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
lidocaine 10 99.44 Very High Very High Very High
ischemia 25 99.32 Very High Very High Very High
Angina 25 99.20 Very High Very High Very High
anesthesia 12 99.06 Very High Very High Very High
adenocard 7 99.06 Very High Very High Very High
antagonist 5 98.84 Very High Very High Very High
Morphine 10 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 2 Under Development 4 99.90 Very High Very High Very High
Coronary Heart Disease 6 99.68 Very High Very High Very High
Coronary Stenosis 2 99.46 Very High Very High Very High
Increased Venous Pressure Under Development 43 99.34 Very High Very High Very High
Cv Unclassified Under Development 9 99.32 Very High Very High Very High
Coronary Artery Disease 22 99.24 Very High Very High Very High
Angina 5 99.20 Very High Very High Very High
Thrombosis Related Under Development 1 99.06 Very High Very High Very High
Shock 1 98.84 Very High Very High Very High
Injury 6 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SQ 80,338 (10.0 micrograms/ml) prevented arachidonate-induced release of TXA2 from the isolated perfused guinea pig lung while SQ 24,775 (1.0 microgram/ml) antagonized the contraction of the isolated rat aorta induced by 9,11,AZO-PGH2.
Localization (release) of TXA2 in aorta
1) Confidence 0.76 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6807699 Disease Relevance 0 Pain Relevance 0.12
The clinical improvement was not associated with an increase in the ankle pressure index or a reduction in platelet aggregation and thromboxane A2 release.
Localization (release) of thromboxane A2 in platelet
2) Confidence 0.75 Published 1988 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 3229875 Disease Relevance 0.15 Pain Relevance 0.07
Doxofylline inhibited: (1) PAF-induced bronchoconstriction in vitro, and the concomitant generation of TXA2-like activity in perfused guinea-pig lungs; (2) PAF-induced bronchoconstriction in vivo and the concomitant release of TXA2-like activity into the circulation; (3) PAF-acether-induced pleurisy and the liberation of type C4 leukotriene into the rat pleural cavity.
Localization (release) of TXA2-like in pleural cavity associated with pleurisy
3) Confidence 0.69 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2776832 Disease Relevance 0.31 Pain Relevance 0.06
Relaxation of thromboxane-induced coronary spasm may contribute to the effectiveness of calcium antagonists in variant angina, which may be caused or exacerbated by thromboxane A2 release from platelets.
Localization (release) of thromboxane A2 in platelets associated with angina, antagonist and cva
4) Confidence 0.55 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7063050 Disease Relevance 0.20 Pain Relevance 0.20
Endothelial injury at sites of coronary artery stenosis, platelet attachment, and release of humoral mediators, including thromboxane A2 and serotonin, may be major causes of primary reductions in coronary blood flow leading to unstable angina and acute myocardial infarction (MI).
Localization (release) of thromboxane A2 in platelet associated with coronary stenosis, angina, injury, serotonin and myocardial infarction
5) Confidence 0.55 Published 1988 Journal Postgrad Med Section Abstract Doc Link 2894662 Disease Relevance 1.06 Pain Relevance 0.32
As noted above, the increased release of endogenous TXA2 can only partly explain our observations.
Localization (release) of TXA2
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.13 Pain Relevance 0
On the other hand, the cerebrovascular endothelium is not likely to be the only source of TXA2 release since L-NAME induced vasomotion in only 3 out of 32 isolated MCAs in vitro, suggesting that vascular TXA2 production by itself may not be sufficient to evoke vasomotion even in case of diminished NO synthesis.
Localization (release) of TXA2 in endothelium
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.64 Pain Relevance 0.10
NO reportedly suppresses the synthesis of TXA2 [29] and inhibition of NOS was recently reported to enhance TXA2 release also from cerebrovascular endothelial cells [17].
Localization (release) of TXA2 in endothelial cells
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.69 Pain Relevance 0.12
Since NO suppresses platelet aggregation as well as vascular release of TXA2, NO-deficiency is often associated with activation of TP-receptors.
Localization (release) of TXA2 in platelet
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.74 Pain Relevance 0.12
Using the Bi-Digital O-Ring Test Molecular Identification Method, we were able to localize substance P and thromboxane B2 (a good indicator of the presence and degree of circulatory disturbances) in the painful area along with virus or bacteria.
Localization (localize) of thromboxane B2 associated with pain and substance p
10) Confidence 0.44 Published 1990 Journal Acupunct Electrother Res Section Abstract Doc Link 1973580 Disease Relevance 0.88 Pain Relevance 0.86
Enhanced prostaglandin E2 and thromboxane B2 release from resident peritoneal macrophages isolated from morphine-dependent rats.
Localization (release) of thromboxane B2 in peritoneal macrophages associated with morphine
11) Confidence 0.37 Published 1987 Journal FEBS Lett. Section Title Doc Link 3036576 Disease Relevance 0 Pain Relevance 0.54
We have simultaneously measured in vitro isometric contractility of pregnant rat uteri with the release of prostaglandin F2 alpha (PGF), 6-keto-prostaglandin F1 alpha (6-k-PGF1 alpha) and thromboxane B2 (TXB2) into the bathing medium under various conditions.
Localization (release) of thromboxane B2
12) Confidence 0.15 Published 1982 Journal Biol. Reprod. Section Abstract Doc Link 6950795 Disease Relevance 0.09 Pain Relevance 0.09
Reduced responsiveness of platelets to prostacyclin, reported in vitro in patients with coronary artery disease, has been thought to be a factor predisposing toward coronary thrombosis and vasospasm as a result of enhanced in vivo release of cyclic endoperoxides and thromboxane A2 by the platelets.
Localization (release) of thromboxane A2 in coronary artery associated with coronary artery disease, increased venous pressure under development and thrombosis related under development
13) Confidence 0.11 Published 1986 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 3016061 Disease Relevance 0.64 Pain Relevance 0.14
Excretion of thromboxane A2 and prostacyclin metabolites before and after exercise testing in patients with and without signs of ischemic heart disease.
Localization (Excretion) of thromboxane A2 in heart associated with coronary heart disease
14) Confidence 0.11 Published 1990 Journal Circulation Section Title Doc Link 2225375 Disease Relevance 0.66 Pain Relevance 0.34
Release of thromboxane B2 was also dose-dependently inhibited by acetaminophen.
Localization (Release) of thromboxane B2
15) Confidence 0.11 Published 2005 Journal Anesthesiology Section Body Doc Link 16192763 Disease Relevance 0 Pain Relevance 0
Ten and 90 min after infusion, platelet function was assessed by photometric aggregometry and by measuring release of thromboxane B2, analgesia by cold pressor test, and plasma acetaminophen concentrations by high-performance liquid chromatography.
Localization (release) of thromboxane B2 in plasma
16) Confidence 0.11 Published 2005 Journal Anesthesiology Section Body Doc Link 16192763 Disease Relevance 0 Pain Relevance 0
In contrast, in patients with comparable coronary artery disease and comparable lactate production who were given ibuprofen, no release of thromboxane B2 (p = 0.05 compared with patients given placebo) or cathepsin D (p less than 0.01 compared with patients given placebo) occurred after pacing-induced ischemia.
Localization (release) of thromboxane B2 in coronary artery associated with coronary artery disease and ischemia
17) Confidence 0.06 Published 1983 Journal Am. J. Cardiol. Section Abstract Doc Link 6829434 Disease Relevance 0.47 Pain Relevance 0.25
These findings suggest that ibuprofen stabilizes membranes and prevents platelet-activated release of thromboxane A2 in pacing-induced myocardial ischemia.
Localization (release) of thromboxane A2 in platelet associated with coronary artery disease and ischemia
18) Confidence 0.06 Published 1983 Journal Am. J. Cardiol. Section Abstract Doc Link 6829434 Disease Relevance 0.48 Pain Relevance 0.20
This exercise-induced vasoconstriction has been associated with the occurrence of myocardial ischemia and has been believed to be the result of endothelial dysfunction, with a reduced release or production of EDRF, increased sympathetic stimulation, enhanced platelet aggregation with release of thromboxane A2 and serotonin, or a passive collapse of the disease-free wall segment within the stenosis (the Bernoulli effect), or a combination of any of these.
Localization (release) of thromboxane A2 in platelet associated with pathologic constriction, coronary artery disease, ischemia, shock, disease, increased venous pressure under development and serotonin
19) Confidence 0.04 Published 2000 Journal Coron. Artery Dis. Section Abstract Doc Link 10860181 Disease Relevance 0.83 Pain Relevance 0.25
[The participation of the sympathetic nervous system in thromboxane A2 release induced by limb ischemia].
Localization (release) of thromboxane A2 in limb associated with ischemia
20) Confidence 0.03 Published 1989 Journal Masui Section Title Doc Link 2733138 Disease Relevance 0.25 Pain Relevance 0.36

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