INT110425

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.48
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAE) plasma membrane (ITGAE)
Anatomy Link Frequency
T-cell 3
regulatory T cells 1
ITGAE (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 10 99.72 Very High Very High Very High
Inflammation 31 91.20 High High
metalloproteinase 18 80.64 Quite High
cytokine 25 75.04 Quite High
abdominal pain 1 68.32 Quite High
vincristine 2 61.04 Quite High
Opioid 3 53.84 Quite High
Crohn's disease 1 51.08 Quite High
antagonist 9 50.52 Quite High
psoriasis 38 50.00 Quite Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 18 98.32 Very High Very High Very High
Frailty 3 95.34 Very High Very High Very High
Leukemia 3 93.20 High High
INFLAMMATION 31 91.20 High High
Cancer 192 89.08 High High
Psoriasis 48 88.16 High High
Inflammatory Bowel Disease 2 85.56 High High
Celiac Disease 13 84.28 Quite High
Ascariasis 1 77.64 Quite High
Giardiasis 1 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eleven patients (7.0%) with persisting (partial) villous atrophy were considered to have RCD; 5 of them developed EATL [27].RCD type I is characterized by normal expression of T-cell antigens and polyclonal TCR gene rearrangement.RCD type II is characterized by an abnormal IEL phenotype with the expression of intracytoplasmic CD3e, surface CD103, and the lack of classic surface T-cell markers such as CD8, CD4, and TCR-alpha/beta.
Gene_expression (expression) of CD103 in T-cell associated with frailty
1) Confidence 0.58 Published 2006 Journal Gastrointest. Endosc. Clin. N. Am. Section Abstract Doc Link 16644460 Disease Relevance 1.01 Pain Relevance 0.03
ITGAE Integrin alphae
Gene_expression (alphae) of ITGAE
2) Confidence 0.56 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.40 Pain Relevance 0.32
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of ITGAE
3) Confidence 0.44 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.63 Pain Relevance 0.04
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (overexpressed) of ITGAE
4) Confidence 0.44 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.59 Pain Relevance 0.04
The lymphoma cells were positive for CD2, CD3, CD5, CD8, and T-cell receptor (TCR) beta F1, but negative for CD4, CD19, CD20, CD103, and CD56.
Neg (negative) Gene_expression (negative) of CD103 in T-cell associated with lymphatic system cancer
5) Confidence 0.43 Published 2003 Journal J. Gastroenterol. Section Abstract Doc Link 12743779 Disease Relevance 0.78 Pain Relevance 0.10
There are two subsets of CD8+ T lymphocytes: an epidermal homing subset expressing CD103 (integrin ?
Gene_expression (expressing) of CD103 in T lymphocytes
6) Confidence 0.37 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721342 Disease Relevance 0.79 Pain Relevance 0.18
The majority of CD4+CD25high regulatory T cells express CCR4 and CCR8 [59], but other chemokine receptors and integrin molecules, such CD103, are also present.
Gene_expression (present) of CD103 in regulatory T cells associated with chemokine
7) Confidence 0.17 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.29 Pain Relevance 0.21

General Comments

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