INT110427

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2011
Negated 3
Speculated 4
Reported most in Body
Documents 199
Total Number 204
Disease Relevance 176.11
Pain Relevance 23.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
plasma 18
macrophage 8
osteoblast 5
monocyte 4
lung 4
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1290 100.00 Very High Very High Very High
chemokine 243 100.00 Very High Very High Very High
fibrosis 929 99.96 Very High Very High Very High
Multiple sclerosis 8 99.92 Very High Very High Very High
Acupuncture 90 99.72 Very High Very High Very High
Sciatic nerve 14 99.64 Very High Very High Very High
Spinal cord 62 99.62 Very High Very High Very High
Central nervous system 57 99.20 Very High Very High Very High
cytokine 982 99.16 Very High Very High Very High
agonist 24 99.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 5927 100.00 Very High Very High Very High
Targeted Disruption 1641 100.00 Very High Very High Very High
INFLAMMATION 1247 100.00 Very High Very High Very High
Renal Disease 797 100.00 Very High Very High Very High
Osteoporosis 657 100.00 Very High Very High Very High
Cardiovascular Disorder Under Development 672 99.96 Very High Very High Very High
Immunization 18 99.96 Very High Very High Very High
Multiple Sclerosis 30 99.92 Very High Very High Very High
Hypercalcemia 67 99.88 Very High Very High Very High
Stomach Cancer 290 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This decrease in OPN protein expression was associated with a threefold decrease in the number of cells that migrated, as compared with the vector-transfected Met control.
Gene_expression (expression) of OPN protein
1) Confidence 0.78 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.51 Pain Relevance 0
Overall, we observed a direct relationship between OPN protein expression and cell migration.
Gene_expression (expression) of OPN protein
2) Confidence 0.78 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.27 Pain Relevance 0
In turn, with the overexpression of the OPN protein in the Db-S cells (3.5-fold higher than the control Db cells and 6.5-fold higher than the Met-As cells), there was a significant increase in the migratory potential of these cells.
Gene_expression (overexpression) of OPN protein
3) Confidence 0.78 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.48 Pain Relevance 0
Using SSH in conjunction with microarrays, we identified osteopontin (OPN) as a very highly expressed gene that was expressed more than threefold higher in the Met tumor lines compared with the Db tumor lines.
Gene_expression (expressed) of osteopontin associated with cancer
4) Confidence 0.78 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.16 Pain Relevance 0
In the Met lines, using antisense methodology, we were able to significantly decrease the OPN protein expression to nearly undetectable levels.
Gene_expression (expression) of OPN protein
5) Confidence 0.78 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.57 Pain Relevance 0
OPN transcript expression in Met and Db cell lines and tumors
Gene_expression (expression) of OPN transcript associated with cancer
6) Confidence 0.78 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.78 Pain Relevance 0
Therefore, in our Met model, due to the activation of PI3-K, OPN gene expression may be directly activated via PI3-K, or it may be activated further downstream or via cross-talk through the MAPK pathway.
Gene_expression (expression) of OPN gene
7) Confidence 0.78 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.46 Pain Relevance 0
We therefore postulated that this level of OPN overexpression would have further consequences in the in vivo experiments.
Gene_expression (overexpression) of OPN
8) Confidence 0.78 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.52 Pain Relevance 0
Osteopontin (OPN) is expressed in many tissues during inflammatory responses.
Gene_expression (expressed) of Osteopontin associated with inflammatory response
9) Confidence 0.77 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17392476 Disease Relevance 0.75 Pain Relevance 0.37
Osteopontin (OPN) is expressed in many tissues during inflammatory responses.
Gene_expression (expressed) of OPN associated with inflammatory response
10) Confidence 0.77 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17392476 Disease Relevance 0.75 Pain Relevance 0.37
SPP1/OPN has also been reported to be overexpressed in gastric cancers and increasing levels have been detected with progression of disease [41].
Gene_expression (overexpressed) of OPN associated with disease and stomach cancer
11) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.15 Pain Relevance 0.11
Based on rat calvarial osteoblast-like (ROB) cell studies, Opn is expressed during day 13 to day 15 of osteoblast differentiation.
Gene_expression (expressed) of Opn in osteoblast associated with osteoporosis
12) Confidence 0.73 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.42 Pain Relevance 0
Other studies have reported that Opn expression is modulated by osteoblast stimulation in vivo, resulting in dramatically increased Opn [17,29].
Gene_expression (expression) of Opn in osteoblast associated with osteoporosis
13) Confidence 0.73 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.43 Pain Relevance 0
Therefore, we aimed to characterize the differences between stem and progenitor cells in vitro by analyzing the differentiation capacities of these cells using three approaches: biochemical assays, morphological characterization and genetic analysis involving Opn, CatK and Sca-1 expressions.
Gene_expression (expressions) of Opn in stem
14) Confidence 0.73 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.22 Pain Relevance 0
To observe a more direct association of OPN and metastatic potential, we used our model system, with its metastatic line and a nonmetastatic line, to manipulate OPN expression by overexpressing it in the nonmetastatic line and by abrogating its expression in the metastatic line, and observing whether the presence or absence of OPN can affect the phenotype with regard to metastasis.
Gene_expression (expression) of OPN associated with metastasis
15) Confidence 0.68 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.74 Pain Relevance 0
In addition, it has been shown, by immunohistochemistry and in situ hybridization, that OPN expression is associated with decreased disease survival and decreased overall survival in node-negative breast cancer [40].
Gene_expression (expression) of OPN in node associated with breast cancer and disease
16) Confidence 0.68 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.01 Pain Relevance 0
In the normal lactating mammary gland, OPN is predominantly found in the lumen of ducts and alveoli.
Gene_expression (found) of OPN in lumen
17) Confidence 0.68 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.72 Pain Relevance 0
Our studies suggest that, in the PyV-mT model, an active PI3-K pathway is associated with or induces OPN expression.
Gene_expression (expression) of OPN
18) Confidence 0.68 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.42 Pain Relevance 0
In order to test this hypothesis, we generated Met sublines and Db sublines having suppressed or enforced expression of OPN, respectively.
Gene_expression (expression) of OPN
19) Confidence 0.68 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.06 Pain Relevance 0
Maglione and colleagues [52] have shown OPN protein expression in nontransplanted mammary tumors derived from PyV-mT transgenic mice, and we have shown that nontransplanted mammary tumors derived from Db transgenic mice do not stain positive for OPN protein (unpublished results).
Gene_expression (expression) of OPN protein associated with targeted disruption and cancer
20) Confidence 0.68 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.48 Pain Relevance 0

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