INT110428

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.88
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp23) endoplasmic reticulum (Mmp23)
Anatomy Link Frequency
macrophages 2
fibroblasts 2
Mmp23 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 45 100.00 Very High Very High Very High
Inflammatory response 10 99.32 Very High Very High Very High
tolerance 9 97.40 Very High Very High Very High
chemokine 6 95.48 Very High Very High Very High
cytokine 40 94.88 High High
Inflammation 61 93.08 High High
Tendonitis 2 75.00 Quite High
rheumatoid arthritis 14 55.72 Quite High
Arthritis 60 50.00 Quite Low
fibrosis 5 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 24 99.90 Very High Very High Very High
INFLAMMATION 72 99.32 Very High Very High Very High
Cardiomyopathy 3 97.90 Very High Very High Very High
Obesity 126 97.68 Very High Very High Very High
Arthropathy 7 92.60 High High
Infection 3 92.40 High High
Rotator Cuff Tears 6 90.80 High High
Rupture 1 88.16 High High
Hypertrophy 10 87.92 High High
Oral Submucous Fibrosis 2 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These crystals stimulate metalloproteinase production in vitro and also suppress metalloproteinase inhibitor production.
Negative_regulation (suppress) of Gene_expression (production) of metalloproteinase associated with metalloproteinase
1) Confidence 0.17 Published 2003 Journal Curr Rheumatol Rep Section Abstract Doc Link 12744818 Disease Relevance 0.97 Pain Relevance 0.26
These crystals stimulate metalloproteinase production in vitro and also suppress metalloproteinase inhibitor production.
Negative_regulation (inhibitor) of Gene_expression (production) of metalloproteinase associated with metalloproteinase
2) Confidence 0.13 Published 2003 Journal Curr Rheumatol Rep Section Abstract Doc Link 12744818 Disease Relevance 0.96 Pain Relevance 0.26
METHODS: Primary mice oral fibroblasts were cultured, the effects of borneol on fibroblasts proliferation, cytotoxicity, collagen production, matrix metalloproteinases-2,9 (MMP-2,9) activities and tissue inhibitors of metalloproteinase 1 (TIMP-1) production were tested by methyl thiazolyl tetrazolium assay, lactic dehydrogenase activity assay, chloramine T method, gelatin zymography and enzyme-linked immunosorbent assay, respectively.
Negative_regulation (inhibitors) of Gene_expression (production) of metalloproteinase in fibroblasts
3) Confidence 0.03 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.09 Pain Relevance 0
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Negative_regulation (reduced) of Gene_expression (expression) of metalloproteinase in macrophages associated with metalloproteinase and apoptosis
4) Confidence 0.02 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.21 Pain Relevance 0.17
In a model of TNF-induced cardiomyopathy through cardiac-specific TNFalpha expression, p50 KO mice had improved diastolic and systolic function, suppressed matrix metalloproteinase activity and expression, and improved survival in male mice [53].
Negative_regulation (suppressed) of Gene_expression (expression) of metalloproteinase associated with cardiomyopathy and metalloproteinase
5) Confidence 0.01 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.53 Pain Relevance 0.20
These studies indicate that IDO-mediated tryptophan depletion in vitro results in inhibition of matrix-degrading metalloproteinase enzyme production, suppression of inflammatory responses, and promotion of immune tolerance [3,4].
Negative_regulation (inhibition) of Gene_expression (production) of metalloproteinase associated with inflammatory response, tolerance and metalloproteinase
6) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.12 Pain Relevance 0.44

General Comments

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