INT110434

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 11.37
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
T cells 6
macrophage 4
colon 4
lung 2
N418 2
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 3 100.00 Very High Very High Very High
cOX1 1 100.00 Very High Very High Very High
cytokine 92 98.04 Very High Very High Very High
cINOD 26 94.88 High High
COX-2 inhibitor 3 90.72 High High
Inflammation 165 85.32 High High
aspirin 5 56.48 Quite High
chemokine 10 41.20 Quite Low
anesthesia 13 26.88 Quite Low
isoflurane 5 25.60 Quite Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 437 100.00 Very High Very High Very High
Targeted Disruption 80 100.00 Very High Very High Very High
Adenomatous Polyps 17 100.00 Very High Very High Very High
Colon Cancer 129 99.60 Very High Very High Very High
Cystic Kidney Diseases 8 98.72 Very High Very High Very High
Adenoma 87 97.56 Very High Very High Very High
Infection 222 96.72 Very High Very High Very High
Polyps 117 95.76 Very High Very High Very High
Respiratory Syncytial Virus 248 94.00 High High
INFLAMMATION 175 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second significant feature of the APC gene product is its interaction with the adherins junction proteins called catenins, to date at least three proteins have been identified that interact with APC, these being ?
Positive_regulation (feature) of Gene_expression (product) of APC associated with familial adenomatous polyposis
1) Confidence 0.50 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.07 Pain Relevance 0
Inhaled APC prevents deterioration of lung function in response to alveolar distention
Positive_regulation (response) of Neg (prevents) Gene_expression (prevents) of APC in lung
2) Confidence 0.40 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0 Pain Relevance 0
What to test for first: APC or MUTYH mutation?
Positive_regulation (test) of Gene_expression (mutation) of APC associated with familial adenomatous polyposis
3) Confidence 0.38 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.66 Pain Relevance 0
Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice.
Positive_regulation (Piroxicam-induced) of Gene_expression (regression) of APC associated with cox1 and adenomatous polyps
4) Confidence 0.37 Published 2003 Journal J Invest Surg Section Title Doc Link 12746190 Disease Relevance 1.21 Pain Relevance 0.29
mutation of the COX-2 gene into Apc?
Positive_regulation (into) of Gene_expression (mutation) of Apc
5) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.88 Pain Relevance 0.53
The two genes, Apc and Siah1, which were found to be downregulated in Dll1 mutants, are known to act via ?
Positive_regulation (act) of Gene_expression (found) of Apc
6) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.30 Pain Relevance 0
This advantage is well illustrated here because our TERT gene set derived from mouse skin matched Wnt pathway patterns seen with conditional deletion of the beta-catenin regulator Apc in mouse gastrointestinal tract and with overexpression of Apc in human colon cancer cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Apc in colon associated with colon cancer
7) Confidence 0.30 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0
The infected Apc?
Positive_regulation (infected) of Gene_expression (infected) of Apc
8) Confidence 0.30 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.55 Pain Relevance 0.06
Moreover, macrophage depletion in Apc?
Positive_regulation (Moreover) of Gene_expression (depletion) of Apc in macrophage
9) Confidence 0.30 Published 2008 Journal EMBO J Section Abstract Doc Link PMC2413189 Disease Relevance 0.58 Pain Relevance 0
Moreover, macrophage depletion in Apc?
Positive_regulation (Moreover) of Gene_expression (Moreover) of Apc in macrophage
10) Confidence 0.30 Published 2008 Journal EMBO J Section Abstract Doc Link PMC2413189 Disease Relevance 0.58 Pain Relevance 0
Furthermore, APC are also capable of activating latent TGF-?
Positive_regulation (activating) of Gene_expression (capable) of APC
11) Confidence 0.28 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.30 Pain Relevance 0.20
This advantage is well illustrated here because our TERT gene set derived from mouse skin matched Wnt pathway patterns seen with conditional deletion of the beta-catenin regulator Apc in mouse gastrointestinal tract and with overexpression of Apc in human colon cancer cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Apc in colon associated with colon cancer
12) Confidence 0.22 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0
Since both CD11c and CD80 are expressed widely on murine APC we asked whether the presence of CD11c on CD8+ T cells is due to expression by T cells rather than to membrane transfer from APC during T cell priming.
Spec (whether) Positive_regulation (membrane) of Gene_expression (transfer) of APC in T cells
13) Confidence 0.16 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.58 Pain Relevance 0
Since both CD11c and CD80 are expressed widely on murine APC we asked whether the presence of CD11c on CD8+ T cells is due to expression by T cells rather than to membrane transfer from APC during T cell priming.
Positive_regulation (transfer) of Gene_expression (transfer) of APC in T cells
14) Confidence 0.16 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.58 Pain Relevance 0
Surface molecules such as CD80 can be transferred from APC to T cells by cell-cell contact [13].
Positive_regulation (transferred) of Gene_expression (transferred) of APC in T cells
15) Confidence 0.16 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.47 Pain Relevance 0
We hypothesized that CD11c is a marker of antigen-specific cytotoxic T cells, which is expressed following activation, rather than being transferred from APC during cell-cell interactions.
Positive_regulation (transferred) of Gene_expression (transferred) of APC in cytotoxic T cells
16) Confidence 0.16 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.78 Pain Relevance 0
treatment of microglia promotes APC function of these cells when they are challenged with A?
Positive_regulation (promotes) of Gene_expression (function) of APC in microglia
17) Confidence 0.14 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.26 Pain Relevance 0.18
Their APC capacity is much stronger than that of M?
Positive_regulation (stronger) of Gene_expression (capacity) of APC
18) Confidence 0.14 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.03
The cells were stained with the following rat anti-mouse monoclonal antibodies: APC anti-CD11c (clone N418) and PE anti-NK 1.1 (clone PK136) from eBioscience; R-R-PE anti-CD8?
Positive_regulation (following) of Gene_expression (anti) of APC in N418
19) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
When APC function is lost, ?
Positive_regulation (When) of Gene_expression (function) of APC associated with familial adenomatous polyposis
20) Confidence 0.06 Published 2008 Journal Ann Surg Oncol Section Body Doc Link PMC2518080 Disease Relevance 1.85 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox