INT110444

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 2.00
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)
Anatomy Link Frequency
SCN 2
macrophages 1
kidney 1
Atf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 99.20 Very High Very High Very High
opioid receptor 3 99.04 Very High Very High Very High
agonist 1 98.46 Very High Very High Very High
nMDA receptor 2 97.44 Very High Very High Very High
Anterior cingulate cortex 5 95.92 Very High Very High Very High
Calcium channel 1 93.92 High High
Delta opioid receptors 5 91.32 High High
antagonist 2 78.48 Quite High
Glutamate receptor 4 78.00 Quite High
tetrodotoxin 3 76.64 Quite High
Disease Link Frequency Relevance Heat
Shock 4 99.72 Very High Very High Very High
Apoptosis 152 96.60 Very High Very High Very High
Infection 66 96.00 Very High Very High Very High
Mycobacterial Infection 141 87.36 High High
Death 12 78.40 Quite High
Neurodegenerative Disease 2 75.00 Quite High
Cognitive Disorder 1 73.32 Quite High
Pain 1 59.20 Quite High
Drug Dependence 1 58.36 Quite High
Mental Disorders 1 57.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that Sult4a1 is a target gene for the mu-opioid receptor signaling pathway and other pathways involving activation of CREB and ATF-2.
Positive_regulation (activation) of ATF-2 associated with opioid receptor
1) Confidence 0.50 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0 Pain Relevance 0.22
Here, we tested the putative role of GRP as an intra-SCN light signal at the behavioral and cellular levels, and we also tested whether GRP actions are dependent on activation of the cAMP response element-binding protein (CREB) pathway and Per1.
Spec (whether) Positive_regulation (activation) of cAMP response element-binding protein in SCN
2) Confidence 0.46 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.07
Gastrin-releasing peptide mediates light-like resetting of the suprachiasmatic nucleus circadian pacemaker through cAMP response element-binding protein and Per1 activation.
Positive_regulation (activation) of cAMP response element-binding protein in suprachiasmatic nucleus
3) Confidence 0.46 Published 2007 Journal J. Neurosci. Section Title Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.06
Furthermore, this effect involved phosphorylation of cAMP response element-binding protein and activation of the tropomyosin-related kinase (Trk) receptors.
Positive_regulation (activation) of cAMP response element-binding protein
4) Confidence 0.38 Published 2008 Journal Cereb. Cortex Section Abstract Doc Link 17965127 Disease Relevance 0.55 Pain Relevance 0.43
These studies determined whether a DOR agonist alone ([D-Ala(2)-D-Leu(5)]enkephalin; DADLE) affects phosphorylation of the activating transcription factor (ATF-2) and its interaction with the MAPK, c-Jun NH(2)-terminal kinase (JNK).
Spec (whether) Positive_regulation (activating) of ATF-2 associated with agonist and enkephalin
5) Confidence 0.36 Published 2003 Journal Cell. Immunol. Section Abstract Doc Link 12747953 Disease Relevance 0 Pain Relevance 0.32
Tilly et al., [39]described a 2-fold increase in the enzymatic activity of MAPKAPK2 at 10 minutes after 820 mOsm mannitol-induced hyperosmotic treatment in human intestine 407 cells [39]; while Watts et al. demonstrated in rat medullary thick ascending limb (MTAL) kidney cells a 2.3-fold increase in ATF-2 (downstream transcription factor of p38 MAPK) phosphorylation with 0.3 M mannitol following 15 minutes treatment [40].
Positive_regulation (increase) of ATF-2 in kidney
6) Confidence 0.34 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Both AC1 and CaMKIV contribute to the regulation of FMRP by group I mGluRs probably through cAMP response element-binding protein activation.
Positive_regulation (activation) of cAMP response element-binding protein
7) Confidence 0.31 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434517 Disease Relevance 0.25 Pain Relevance 0.36
Although NCoA6 was initially cloned as coactivator protein for NRs, its detailed characterization by a number of laboratories has uncovered its potential to enhance the activity of a wide variety of other transcription factors including c-Fos, c-Jun, CREB, NF-kB, ATF-2, heat shock factors, E2F-1, SRF, and Rb, p53 and Sox9 [Goo et al., 2004; Hong et al., 2004a; Hong et al., 2004b; Ko et al., 2000; Kong et al., 2003; Lee et al., 1999; Lee et al., 2000; Mahajan et al., 2007; Mahajan et al., 2002; Mahajan and Samuels, 2000; Mahajan and Samuels, 2005].
Positive_regulation (enhance) of ATF-2 associated with shock
8) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.27 Pain Relevance 0.03
secretion by macrophages needs to be investigated in more detail but activation of transcription factors such as ATF-2, Elk-1 and c-Jun upon JNK activation have been reported and would lead to an increase in TNF-?
Spec (investigated) Positive_regulation (activation) of ATF-2 in macrophages
9) Confidence 0.06 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.93 Pain Relevance 0

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