INT110445

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Context Info
Confidence 0.09
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.58
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
fat 1
stem cell 1
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 99.66 Very High Very High Very High
agonist 8 98.92 Very High Very High Very High
Delta opioid receptors 10 98.76 Very High Very High Very High
Morphine 10 97.36 Very High Very High Very High
addiction 4 97.00 Very High Very High Very High
withdrawal 1 96.76 Very High Very High Very High
antagonist 16 96.36 Very High Very High Very High
Inflammation 64 96.28 Very High Very High Very High
Central nervous system 24 94.84 High High
narcan 2 94.12 High High
Disease Link Frequency Relevance Heat
Apoptosis 109 99.28 Very High Very High Very High
Cancer 218 99.06 Very High Very High Very High
Endometriosis (extended) 6 98.44 Very High Very High Very High
Weight Loss 1 97.60 Very High Very High Very High
Morphine Dependence 3 97.36 Very High Very High Very High
Myelodysplastic Syndromes 60 96.84 Very High Very High Very High
INFLAMMATION 95 96.28 Very High Very High Very High
Acute Myeloid Leukemia 2 95.92 Very High Very High Very High
Myelofibrosis 28 95.68 Very High Very High Very High
Leukemia 9 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylation of ERK was reduced by tyrphostin AG1478, an inhibitor of phosphorylation of the epidermal growth factor receptor (EGFR), and by heparin, which neutralizes heparin-binding epithelial growth factor (HB-EGF), suggesting the involvement of a transactivation process, in which alpha(2)-adrenergic stimulation leads to proteolytic shedding of HB-EGF (and perhaps other EGFR agonists) from transmembrane-spanning precursors.
Phosphorylation (phosphorylation) of factor associated with agonist
1) Confidence 0.09 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834899 Disease Relevance 0.05 Pain Relevance 0.20
Phosphorylation of activating transcription factor in murine splenocytes through delta opioid receptors.
Phosphorylation (Phosphorylation) of factor associated with delta opioid receptors
2) Confidence 0.08 Published 2003 Journal Cell. Immunol. Section Title Doc Link 12747953 Disease Relevance 0 Pain Relevance 0.38
These studies determined whether a DOR agonist alone ([D-Ala(2)-D-Leu(5)]enkephalin; DADLE) affects phosphorylation of the activating transcription factor (ATF-2) and its interaction with the MAPK, c-Jun NH(2)-terminal kinase (JNK).
Phosphorylation (phosphorylation) of factor associated with agonist and enkephalin
3) Confidence 0.08 Published 2003 Journal Cell. Immunol. Section Abstract Doc Link 12747953 Disease Relevance 0 Pain Relevance 0.32
CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence.
Phosphorylation (phosphorylation) of factor associated with addiction and morphine
4) Confidence 0.05 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.27 Pain Relevance 1.10
Based upon the potential for imatinib mesylate to inhibit the tyrosine kinase phosphorylation of c-Kit (the stem cell factor receptor essential for erythroid progenitor cell proliferation) imatinib mesylate was tested in a variety of trials for PV.
Phosphorylation (phosphorylation) of factor in stem cell associated with myelodysplastic syndromes
5) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 0.90 Pain Relevance 0.03
Among these, Cdk1 is the main kinase player during G2/M transition [39] which controls execution of a transcriptional program required for mitosis through phosphorylation of Plk1 and Aurora B and subsequent activation of FoxM1, a key transcription factor during G2/M transition [35], [40].
Phosphorylation (phosphorylation) of factor
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.05 Pain Relevance 0
The expression levels of the angiogenic factors, bFGF, IGF-1, PDGF-BB, VEGFR-2, EPOR and MMP-2, the cell survival factor PKB and phosphorylated PKB, and the pro-apoptotic factors caspase 3 and cytochrome c were determined in homogenates of the harvested fat grafts using western blot analysis.
Phosphorylation (phosphorylated) of factor in fat associated with apoptosis
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.10 Pain Relevance 0
We have shown activation of the EP2 and FP receptors can lead to phosphorylation of ERK1/2 via the activation of c-Src and transphosphorylation of the epidermal growth factor receptor (EGFR) in Ishikawa cells and endometrial adenocarcinoma explants ex vivo [7,18].
Phosphorylation (transphosphorylation) of factor associated with endometriosis (extended)
8) Confidence 0.02 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.44 Pain Relevance 0.13
Celecoxib caused phosphorylation of eukaryotic translation initiation factor 2 kinase (PERK) and eukaryotic initiation factor-2alpha (eIF2alpha) and production of activating transcription factor (ATF)4 mRNA.
Phosphorylation (phosphorylation) of factor
9) Confidence 0.01 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.80 Pain Relevance 0.47
Moreover, SRPK1 and SRPK2 are known to phosphorylate the ASF/SF2 splicing factor with high specificity (21, 31, 53).
Phosphorylation (phosphorylate) of factor
10) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.42 Pain Relevance 0
These two kinases are able to phosphorylate the splicing factor, ASF/SF2 and all these components are involved in the choice of the PSS in VEGF.
Phosphorylation (phosphorylate) of factor
11) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.48 Pain Relevance 0
Secondly, we found that THL could inhibit, in cancer cells, the activity of ERK1/2 (Fig 2D), which phosphorylates the transcription factor Sp1 and causes the recruitment of Sp1 to the vegf-A promoter [65].
Phosphorylation (phosphorylates) of factor associated with cancer
12) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 1.23 Pain Relevance 0.03
trigger the phosphorylation and degradation of the inhibitory factor, I?
Phosphorylation (phosphorylation) of factor
13) Confidence 0.01 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.56 Pain Relevance 0.41
First and foremost, the previously reported down-stream target of MCSP, FAK, was dephosphorylated by a factor 2 compared to medium control.
Phosphorylation (dephosphorylated) of factor
14) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.12 Pain Relevance 0
Oligomerized PERK undergoes autophosphorylation and then phosphorylates two substrates, the bZIP transcription factor NRF2 and elongation factor 2?
Phosphorylation (phosphorylates) of factor
15) Confidence 0.01 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.16 Pain Relevance 0

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