INT110458

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Context Info
Confidence 0.35
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atf2, Mapk8) cytosol (Mapk8) signal transduction (Mapk8)
mitochondrion (Mapk8) intracellular (Atf2) DNA binding (Atf2)
Atf2 (Mus musculus)
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 98.54 Very High Very High Very High
Delta opioid receptors 10 98.28 Very High Very High Very High
agonist 2 97.80 Very High Very High Very High
antagonist 2 87.16 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, DADLE stimulated phosphorylation of 71kDa ATF-2 and its association with JNK, suggesting that JNK is activated through DORs.
ATF-2 Binding (association) of JNK associated with delta opioid receptors
1) Confidence 0.35 Published 2003 Journal Cell. Immunol. Section Abstract Doc Link 12747953 Disease Relevance 0 Pain Relevance 0.35
These studies determined whether a DOR agonist alone ([D-Ala(2)-D-Leu(5)]enkephalin; DADLE) affects phosphorylation of the activating transcription factor (ATF-2) and its interaction with the MAPK, c-Jun NH(2)-terminal kinase (JNK).
ATF-2 Binding (interaction) of JNK associated with agonist and enkephalin
2) Confidence 0.35 Published 2003 Journal Cell. Immunol. Section Abstract Doc Link 12747953 Disease Relevance 0 Pain Relevance 0.32

General Comments

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