INT11047

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Context Info
Confidence 0.66
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 28.70
Pain Relevance 9.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 4
epithelial cell 4
fibroblasts 4
heart 4
mononuclear cells 4
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 669 100.00 Very High Very High Very High
cytokine 570 100.00 Very High Very High Very High
Inflammatory response 94 100.00 Very High Very High Very High
imagery 91 99.96 Very High Very High Very High
cva 390 99.68 Very High Very High Very High
Infliximab 68 99.26 Very High Very High Very High
substance P 7 99.26 Very High Very High Very High
headache 16 99.12 Very High Very High Very High
Pain 36 98.76 Very High Very High Very High
Arthritis 76 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 881 100.00 Very High Very High Very High
Cancer 558 100.00 Very High Very High Very High
Injury 239 100.00 Very High Very High Very High
Coronary Heart Disease 173 100.00 Very High Very High Very High
Necrosis 49 100.00 Very High Very High Very High
Influenza Virus Infection 23 99.82 Very High Very High Very High
Sepsis 8 99.76 Very High Very High Very High
Cv General 3 Under Development 387 99.68 Very High Very High Very High
Endometriosis (extended) 24 99.68 Very High Very High Very High
Headache Disorders 9 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is not surprising that our MLC protocol induced an increase in IL-6 mRNA and circulating IL-6.
Positive_regulation (induced) of Positive_regulation (increase) of IL-6
1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.09 Pain Relevance 0
IL-6 and IL-6 receptor gene induction occurs as a result of activated STAT proteins and IL-6 mediates the long-term activation of STAT3 through an autocrine loop.


Positive_regulation (occurs) of Positive_regulation (induction) of IL-6
2) Confidence 0.60 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.31 Pain Relevance 0
This in turn activates the STAT family of transcription factors and results in the induction of Interleukin-6 and IL-6 receptor gene.
Positive_regulation (results) of Positive_regulation (induction) of IL-6
3) Confidence 0.60 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.09 Pain Relevance 0
The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations.
Positive_regulation (underestimated) of Positive_regulation (relevance) of interleukin-6 in heart associated with inflammation, coronary heart disease and cytokine
4) Confidence 0.50 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2288623 Disease Relevance 0.69 Pain Relevance 0.10
The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations.
Positive_regulation (underestimated) of Positive_regulation (relevance) of IL-6 in heart associated with inflammation, coronary heart disease and cytokine
5) Confidence 0.50 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2288623 Disease Relevance 0.69 Pain Relevance 0.10
Serum IL-6 was strongly correlated to the increase in muscle IL-6 mRNA (r2?
Positive_regulation (correlated) of Positive_regulation (Serum) of IL-6 in muscle
6) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
The levels of IL-6 have also been measured in the patients with atypical painful disorders
Positive_regulation (measured) of Positive_regulation (levels) of IL-6 associated with pain
7) Confidence 0.47 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804300 Disease Relevance 0.50 Pain Relevance 0.32
Extracranial sources of IL-6 such as those observed in the orthopedic injury patients may have contributed to the increase in IL-6 levels seen in polytrauma patients whose ICP remained below 20 mm Hg (Figure 3C), making them indistinguishable from patients whose ICP ?
Positive_regulation (contributed) of Positive_regulation (sources) of IL-6 associated with injury and cva
8) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 1.36 Pain Relevance 0.21
This time point was chosen as it represented the latest time at which IL-6 serum concentrations were found to be consistently elevated in the ICP ?
Positive_regulation (elevated) of Positive_regulation (concentrations) of IL-6 associated with cva
9) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 0.78 Pain Relevance 0.25
Since the above analysis was performed using pooled samples, it raised the possibility that a large increase in IL-6 levels within a few of the patients would have been sufficient to increase the level of this protein in the entire pooled sample.
Positive_regulation (increase) of Positive_regulation (increase) of IL-6
10) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 0.87 Pain Relevance 0.40
PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of astrocytic IL-6 mRNA, followed by IL-6 protein synthesis.
Positive_regulation (led) of Positive_regulation (induction) of IL-6
11) Confidence 0.45 Published 1998 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 9850935 Disease Relevance 0.75 Pain Relevance 0.16
It has been previously demonstrated that exercise can induce increases in muscle derived IL-6 mRNA and plasma IL-6 concentrations following exercise [25], [26].
Positive_regulation (induce) of Positive_regulation (increases) of IL-6 in plasma
12) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.64 Pain Relevance 0.11
Exposure of HDP fibroblasts to IL-1alpha or TNF-alpha resulted in elevated levels of IL-6 (approximately 3.4 to approximately 10.4-fold) and COX-2 (approximately 5 to approximately 6.2-fold) mRNA.
Positive_regulation (elevated) of Positive_regulation (resulted) of IL-6 in fibroblasts
13) Confidence 0.44 Published 2002 Journal J Endod Section Abstract Doc Link 12017180 Disease Relevance 0.25 Pain Relevance 0.21
Exposure of HDP fibroblasts to IL-1alpha or TNF-alpha resulted in elevated levels of IL-6 (approximately 3.4 to approximately 10.4-fold) and COX-2 (approximately 5 to approximately 6.2-fold) mRNA.
Positive_regulation (resulted) of Positive_regulation (resulted) of IL-6 in fibroblasts
14) Confidence 0.44 Published 2002 Journal J Endod Section Abstract Doc Link 12017180 Disease Relevance 0.25 Pain Relevance 0.21
PGE1 and PGE2, but not PGD2 and PGF2 alpha, led to a rapid and transient induction of IL-6 mRNA, followed by IL-6 protein synthesis.
Positive_regulation (led) of Positive_regulation (induction) of IL-6
15) Confidence 0.44 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9003059 Disease Relevance 0.68 Pain Relevance 0.29
Levels of IL-6 and G-CSF were elevated during the active phase, but the level of IL-1beta did not increase.
Positive_regulation (elevated) of Positive_regulation (elevated) of IL-6
16) Confidence 0.44 Published 2003 Journal Int. J. Hematol. Section Abstract Doc Link 12774928 Disease Relevance 1.86 Pain Relevance 0.24
IL-6 and IL-6 receptor gene induction occurs as a result of activated STAT proteins and IL-6 mediates the long-term activation of STAT3 through an autocrine loop.


Positive_regulation (activated) of Positive_regulation (induction) of IL-6
17) Confidence 0.43 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.36 Pain Relevance 0.03
This in turn activates the STAT family of transcription factors and results in the induction of Interleukin-6 and IL-6 receptor gene.
Positive_regulation (activates) of Positive_regulation (induction) of Interleukin-6
18) Confidence 0.43 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.09 Pain Relevance 0
FGF-2 activity for IL-6 induction was the same as that of IL-17.
Positive_regulation (activity) of Positive_regulation (induction) of IL-6
19) Confidence 0.41 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0
Numerous studies emphasize the important role of IL-6 and TGF-?
Positive_regulation (important) of Positive_regulation (role) of IL-6
20) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 1.69 Pain Relevance 0.13

General Comments

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