INT11048

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 59
Total Number 64
Disease Relevance 42.85
Pain Relevance 6.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 9
NK cells 7
blood 6
lymphocytes 6
lung 4
CD69 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 615 99.28 Very High Very High Very High
endometriosis 469 98.64 Very High Very High Very High
COX-2 inhibitor 1 97.84 Very High Very High Very High
Inflammation 632 96.46 Very High Very High Very High
Angina 2 95.88 Very High Very High Very High
metalloproteinase 7 95.28 Very High Very High Very High
Central nervous system 23 93.28 High High
Inflammatory mediators 28 93.00 High High
Inflammatory response 57 91.76 High High
chemokine 100 89.92 High High
Disease Link Frequency Relevance Heat
Pulmonary Disease 957 99.80 Very High Very High Very High
Endometriosis 810 99.56 Very High Very High Very High
Cicatrix 519 99.40 Very High Very High Very High
Peritonitis 30 99.24 Very High Very High Very High
Nicotine Addiction 1001 99.18 Very High Very High Very High
Apoptosis 177 98.36 Very High Very High Very High
Death 68 98.32 Very High Very High Very High
Dementia 19 96.96 Very High Very High Very High
Disease 189 96.80 Very High Very High Very High
INFLAMMATION 719 96.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We evaluated the effect of timing of BE addition to the culture medium on thymidine uptake, the kinetics of expression of activation markers (CD69, CD25 and CD71) on CD4+ and CD8+ lymphocytes, and of class II MHC antigens on CD14+ cells (monocytes), the kinetics of interleukin-1 (IL-1), interleukin-2 (IL-2) and interferon gamma (IFN-gamma) release, and the cell cycle.
Gene_expression (expression) of CD69 in monocytes
1) Confidence 0.67 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Gene_expression (expression) of CD69 in lymphocytes
2) Confidence 0.67 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.09
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Gene_expression (expression) of CD69 in T cell
3) Confidence 0.62 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.23
Similarly, CD69 antigen expression was significantly higher in scar endometriosis than in the control group.
Gene_expression (expression) of CD69 associated with endometriosis and cicatrix
4) Confidence 0.62 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.92 Pain Relevance 0.58
RCAS1 expression was growing in the eutopic endometrium simultaneously with the growth of the number of CD56-positive cells and CD69 antigen expression.
Gene_expression (expression) of CD69 in endometrium
5) Confidence 0.62 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.06 Pain Relevance 0.14
CD69 antigen expression was on comparable levels in ovarian and scar endometriosis, while in ovarian endometriosis it was significantly higher than in the control group.
Gene_expression (expression) of CD69 associated with endometriosis and cicatrix
6) Confidence 0.62 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.95 Pain Relevance 0.55
In the present study a correlation between CD56 and CD69 expression was observed in ovarian endometriomas (R = 0.53, p = 0.018) as well as in scar endometriomas (R = 0.52, p = 0.04).
Gene_expression (expression) of CD69 associated with endometriosis and cicatrix
7) Confidence 0.62 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.14 Pain Relevance 0.17
The efficacy of stimulation, as evaluated by the expression level of the activation marker CD69, was comparable between week 0 and 12 (median MFI ?
Gene_expression (expression) of CD69
8) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.09 Pain Relevance 0.37
CD69 expression was included to assess the activation status of the cells.
Gene_expression (expression) of CD69
9) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0 Pain Relevance 0.17
They constitutively expressed CD69 and CD25 as well as molecules associated with CD4+ CD25+ regulatory T cells, including cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and Foxp3.
Gene_expression (expressed) of CD69 in cytotoxic T lymphocyte
10) Confidence 0.53 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 16180249 Disease Relevance 0.13 Pain Relevance 0.10
The alterations in RCAS1 and Metallothionein expression are accompanied by changes in CD25, CD56 and CD69 antigens expression on immune cells.
Gene_expression (expression) of CD69 in immune cells
11) Confidence 0.48 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.34 Pain Relevance 0.30
CD25 and CD69 antigen expression was higher in scar and ovarian endometriomas than in the control group.


Gene_expression (expression) of CD69 associated with endometriosis and cicatrix
12) Confidence 0.48 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 1.38 Pain Relevance 0
Five-micrometer sections from each case were stained to visualize expression of RCAS1, MT and CD16-, CD25-, CD69-, CD56-positive cells (mainly lymphocytes) as well as CD68+ cells, or macrophages.
Gene_expression (expression) of CD69 in macrophages
13) Confidence 0.48 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 0.41 Pain Relevance 0.06
Metallothionein, RCAS1, CD25, CD69, CD56, CD16, CD68 antigen expression was assessed by immunohistochemistry in ovarian and scar endometriomas tissue samples which were obtained from 33 patients.
Gene_expression (expression) of CD69 associated with endometriosis and cicatrix
14) Confidence 0.48 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 1.10 Pain Relevance 0
A decrease of CD25 antigen expression with a concomitant increase of CD69 expression has been observed in the endometrium according to the menstrual cycle changes [21].
Gene_expression (expression) of CD69 in endometrium
15) Confidence 0.48 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.13 Pain Relevance 0.24
CD69 and CD38 expression was high and similar between groups, consistent with immune activation.
Gene_expression (expression) of CD69
16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943484 Disease Relevance 0.65 Pain Relevance 0.03
Thus, even though the CD107a data did not reach statistical significance, it supports the evidence of increased cytotoxic activity as indicated by increased expression of CD69.
Gene_expression (expression) of CD69
17) Confidence 0.38 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.15 Pain Relevance 0.03
At the 1:400 dilution, CD69 expression was increased by 32% (p < 0.05) for MTB, and by 36% for CW (p < 0.006).
Gene_expression (expression) of CD69
18) Confidence 0.38 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.26 Pain Relevance 0.03
Conversely, NK cell activation, demonstrated as an increase in CD69 expression, was nearly identical following MTB or CW treatment, across a broad dilution range.
Gene_expression (expression) of CD69 in NK cell
19) Confidence 0.38 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.77 Pain Relevance 0.25
Both MTB and CW showed a clear dose-dependent induction of the expression of CD69 on NK cells (Figure 4A).
Gene_expression (expression) of CD69 in NK cells
20) Confidence 0.38 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.25 Pain Relevance 0.03

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