INT11050

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.40
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL2RA) plasma membrane (IL2RA)
Anatomy Link Frequency
blood 2
IL2R 2
IL2RA (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 3 77.04 Quite High
Antihistamine 2 28.76 Quite Low
cytokine 5 25.00 Low Low
pruritus 4 23.60 Low Low
Pain 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
visual analogue scale 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 40 94.00 High High
Cancer 12 93.80 High High
Mycosis Fungoides 12 86.96 High High
Syndrome 12 86.72 High High
Lymphocytosis 1 86.24 High High
Lumbar Puncture Related Headaches 1 81.52 Quite High
Headache 2 77.04 Quite High
Disease 29 76.76 Quite High
Toxicity 5 76.12 Quite High
Leukemia 5 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the expression of IL2R has been largely thought to be important in T-cell targeting of denileukin diftitox, strategies to upregulate IL2R expression have been explored.
Regulation (important) of Gene_expression (expression) of IL2R in IL2R
1) Confidence 0.41 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.60 Pain Relevance 0
There was a dose-related increase in the number of peripheral blood lymphocytes expressing the T-cell activation antigen CD69 (Leu 23), but no changes were seen in CD25 (interleukin 2 receptor) expression, and no changes were observed in the serum levels of the soluble interleukin 2 receptor.
Neg (no) Regulation (changes) of Gene_expression (expression) of CD25 in blood
2) Confidence 0.16 Published 1992 Journal Cancer Res. Section Abstract Doc Link 1533172 Disease Relevance 0.80 Pain Relevance 0.15
Compared with placebo no significant changes were seen in these markers of activation (CD69) and proliferation (CD71) nor in the expression of the IL-2 receptor (CD25) (Tables 3 and 4) during treatment with zidovudine plus lamivudine.


Neg (no) Regulation (changes) of Gene_expression (expression) of IL-2 receptor
3) Confidence 0.15 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0 Pain Relevance 0

General Comments

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