INT110503

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.71
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADRBK1) signal transduction (ADRBK1) aging (ADRBK1)
plasma membrane (ADRBK1) cytoplasm (ADRBK1)
Anatomy Link Frequency
brains 1
ADRBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 4 99.84 Very High Very High Very High
mu opioid receptor 5 99.76 Very High Very High Very High
methadone 2 97.72 Very High Very High Very High
opiate 11 94.20 High High
opioid receptor 12 93.00 High High
Enkephalin 3 91.36 High High
antagonist 1 88.40 High High
orphanin 7 75.00 Quite High
Opioid 2 75.00 Quite High
addiction 2 70.72 Quite High
Disease Link Frequency Relevance Heat
Overdose 2 98.08 Very High Very High Very High
Opiate Addiction 2 95.60 Very High Very High Very High
Neuroblastoma 3 94.36 High High
Hyperalgesia 1 64.20 Quite High
Dysmenorrhea 1 54.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, specific inhibition of endogenous GRK2 by dominant-negative mutants robustly inhibited OTR phosphorylation and internalization as well as arrestin/OTR interactions.
Negative_regulation (inhibition) of GRK2
1) Confidence 0.53 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.05 Pain Relevance 0.12
OFQ/N treatment (100 nM, 60 min) potentiated DAMGO-induced mu receptor phosphorylation; inhibition of GRK2 or protein kinase C concomitant with OFQ/N treatment blocked the OFQ/N-mediated increase in DAMGO-induced phosphorylation.
Negative_regulation (inhibition) of GRK2 associated with kinase c
2) Confidence 0.47 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.09 Pain Relevance 0.62
This suggests that DAMGO activation of mu-opioid receptors results in GRK2 and GRK3 inactivation of ORL1 upon challenge with OFQ/N.
Negative_regulation (inactivation) of GRK2 associated with mu opioid receptor
3) Confidence 0.35 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.76
In the same brains, significant decreases in the immunodensities of GRK 2 (19%, n=24, P<0.05), GRK 6 (25%, n=24, P<0.002) and beta-arrestin-2 (22%, n=24, P< 0.0005) were also quantitated.
Negative_regulation (decreases) of GRK 2 in brains
4) Confidence 0.27 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14969742 Disease Relevance 0.33 Pain Relevance 1.19

General Comments

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