INT11051

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2011
Negated 9
Speculated 11
Reported most in Body
Documents 415
Total Number 426
Disease Relevance 319.21
Pain Relevance 109.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 42
blood 22
macrophages 19
MNCs 18
monocytes 18
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6071 100.00 Very High Very High Very High
cytokine 5991 100.00 Very High Very High Very High
rheumatoid arthritis 1604 100.00 Very High Very High Very High
Osteoarthritis 971 100.00 Very High Very High Very High
chemokine 574 100.00 Very High Very High Very High
antagonist 331 100.00 Very High Very High Very High
metalloproteinase 250 100.00 Very High Very High Very High
bradykinin 136 99.98 Very High Very High Very High
qutenza 74 99.98 Very High Very High Very High
substance P 66 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7200 100.00 Very High Very High Very High
Cancer 3380 100.00 Very High Very High Very High
Obesity 1921 100.00 Very High Very High Very High
Rheumatoid Arthritis 1830 100.00 Very High Very High Very High
Infection 1286 100.00 Very High Very High Very High
Necrosis 462 100.00 Very High Very High Very High
Adhesions 375 100.00 Very High Very High Very High
Insulin Resistance 355 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 333 100.00 Very High Very High Very High
Leukemia 159 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells were stimulated with different substances which have previously been shown to activate protein kinase A or C, reactive oxygen intermediates as well as transcription factors such as nuclear factor kappa B and AP-1 and which all result in IL-6 synthesis.
Positive_regulation (result) of Gene_expression (synthesis) of IL-6
1) Confidence 0.69 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.54 Pain Relevance 0.26
Stimulation of interleukin-6 production in human dental pulp cells by peptidoglycans from Lactobacillus casei.
Positive_regulation (Stimulation) of Gene_expression (production) of interleukin-6 in dental pulp
2) Confidence 0.68 Published 1998 Journal J Endod Section Title Doc Link 9641129 Disease Relevance 0.18 Pain Relevance 0.25
These findings suggest that Gram-positive bacteria, such as L. casei, from carious lesions, might be involved in developing pulpitis through the stimulation of IL-6 production.
Positive_regulation (stimulation) of Gene_expression (production) of IL-6 associated with pulpitis
3) Confidence 0.68 Published 1998 Journal J Endod Section Abstract Doc Link 9641129 Disease Relevance 0.26 Pain Relevance 0.25
ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects.
Positive_regulation (stimulated) of Gene_expression (production) of IL-6
4) Confidence 0.68 Published 2002 Journal J. Rheumatol. Section Body Doc Link 11950021 Disease Relevance 0 Pain Relevance 0
Our findings suggest that topical application of capsaicin to the airway induces IL-6 production from respiratory epithelial cells via activation of TRPV1.
Positive_regulation (induces) of Gene_expression (production) of IL-6 in respiratory associated with qutenza
5) Confidence 0.68 Published 2007 Journal Life Sci. Section Abstract Doc Link 17306835 Disease Relevance 0.11 Pain Relevance 0.51
Capsaicin (10 nM-10 muM) induced production of IL-6 from HNECs and NHBE cells and this effect was inhibited by pretreatment with capsazepine.
Positive_regulation (induced) of Gene_expression (production) of IL-6 associated with qutenza
6) Confidence 0.68 Published 2007 Journal Life Sci. Section Abstract Doc Link 17306835 Disease Relevance 0.12 Pain Relevance 0.59
Capsaicin induces the production of IL-6 in human upper respiratory epithelial cells.
Positive_regulation (induces) of Gene_expression (production) of IL-6 in upper associated with qutenza
7) Confidence 0.68 Published 2007 Journal Life Sci. Section Title Doc Link 17306835 Disease Relevance 0.19 Pain Relevance 0.72
Concomitant overexpression of IL6 and IL6R?
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL6
8) Confidence 0.67 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.89 Pain Relevance 0
Sputum in bronchiectasis stimulated IL-6 production from NHBE cells by 1.9 times.
Positive_regulation (stimulated) of Gene_expression (production) of IL-6 in Sputum associated with bronchiectasis
9) Confidence 0.67 Published 2004 Journal Respir Med Section Abstract Doc Link 15072174 Disease Relevance 0.93 Pain Relevance 0.36
Our results support that sputum in bronchiectasis can stimulate IL-6 production from NHBE cells, and TNF-alpha is an important cytokine mediating the process.
Positive_regulation (stimulate) of Gene_expression (production) of IL-6 in sputum associated with bronchiectasis and cytokine
10) Confidence 0.67 Published 2004 Journal Respir Med Section Abstract Doc Link 15072174 Disease Relevance 0.61 Pain Relevance 0.25
Ibuprofen suppressed sputum-stimulated IL-6 production to levels above control and effect levelled off at 50-100 microg/mi, contrasting the dose-dependent suppression to control level with MK-663 (0.1-10 microg/ml) and to sub-control levels with triptolide (20-1000 ng/ml).
Positive_regulation (stimulated) of Gene_expression (production) of IL-6 in sputum
11) Confidence 0.67 Published 2004 Journal Respir Med Section Abstract Doc Link 15072174 Disease Relevance 0.84 Pain Relevance 0.35
Although calcium concentrations were not measured in this study, it is possible that changes in intracellular calcium concentration as a result of repeated muscle contractions may have contributed to the increase in IL-6 expression [27], [47].
Positive_regulation (increase) of Gene_expression (expression) of IL-6 in muscle
12) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0.05
The pleiotropic roles of IL-6 appear to be dependent on the stimuli, nature of the immune and local tissue responses, and the temporal expression of IL-6 in inducing different phenotypic traits [17], [21], [23].
Positive_regulation (dependent) of Gene_expression (expression) of IL-6
13) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.35 Pain Relevance 0
Excess production of IL-6 also contributes to the anemia of chronic disease common in active RA by increasing hepcidin production, and induces thrombocytosis through increased megakaryocyte differentiation (Ishibashi et al 1993; Andrews 2004.
Positive_regulation (Excess) of Gene_expression (production) of IL-6 in megakaryocyte associated with anaemia, rheumatoid arthritis, thrombosis related under development and chronic disease
14) Confidence 0.62 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 1.02 Pain Relevance 0.31
Increased levels of interleukin-1 (IL)-1, tumor necrosis factor-alpha (TNF-alpha), IL-6, and prostaglandin E2 (PGE2) have been detected in inflamed pulp tissue.
Positive_regulation (Increased) of Gene_expression (levels) of IL-6 in PGE2 associated with necrosis and cancer
15) Confidence 0.62 Published 2002 Journal J Endod Section Abstract Doc Link 12017180 Disease Relevance 0.29 Pain Relevance 0.13
Enhanced production of IL-6, which is associated with bone resorption and inflammatory response, seems to be related to the progression of TMJ disorders.


Spec (seems) Positive_regulation (Enhanced) of Gene_expression (production) of IL-6 in TMJ
16) Confidence 0.60 Published 2002 Journal J. Oral Pathol. Med. Section Body Doc Link 12190816 Disease Relevance 0.06 Pain Relevance 0
Nuclear factor-kappaB (NF-kappaB) is a required transcription factor for Ang II-inducible IL-6 expression.
Positive_regulation (inducible) of Gene_expression (expression) of IL-6
17) Confidence 0.60 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.22 Pain Relevance 0.11
The effects of pravastatin on CRP stimulated IL-6 production varied among individuals.
Positive_regulation (stimulated) of Gene_expression (production) of IL-6
18) Confidence 0.58 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.15 Pain Relevance 0.11
The finding that treatment with a statin has a rapid inhibitory effect on CRP stimulated IL-6 production is of interest, not only because it demonstrates a rapid anti-inflammatory action of a statin ex vivo,but also because IL-6 is thought to be one of the prime regulators of CRP production [37].
Positive_regulation (stimulated) of Gene_expression (production) of IL-6 associated with inflammation
19) Confidence 0.58 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.24 Pain Relevance 0.12
Wilcoxon signed ranks tests were used to compare cytokine production in stimulated and in unstimulated whole blood and to compare stimulated IL-6 and MCP-1 production before and after the administration of pravastatin.
Positive_regulation (stimulated) of Gene_expression (production) of IL-6 in blood associated with cytokine
20) Confidence 0.58 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0 Pain Relevance 0.08

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