INT110515

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.84
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
medulla 3
neurons 2
locus coeruleus 1
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 8 100.00 Very High Very High Very High
Serotonin 4 100.00 Very High Very High Very High
Analgesic 6 99.98 Very High Very High Very High
cINOD 3 99.90 Very High Very High Very High
COX2 4 99.68 Very High Very High Very High
antagonist 12 99.20 Very High Very High Very High
Endocannabinoid 16 98.98 Very High Very High Very High
Endogenous opioid 3 98.58 Very High Very High Very High
Inflammation 4 97.84 Very High Very High Very High
Rostral ventromedial medulla 8 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 6 99.44 Very High Very High Very High
INFLAMMATION 5 97.84 Very High Very High Very High
Hyperalgesia 7 97.32 Very High Very High Very High
Gallstones 5 95.72 Very High Very High Very High
Urological Neuroanatomy 16 93.40 High High
Pain 1 88.52 High High
Ganglion Cysts 5 87.40 High High
Inflammatory Pain 1 75.00 Quite High
Pressure And Volume Under Development 1 45.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1-mediated calcium responses in adult DRG neurons; the role of CB receptors.
Regulation (Effects) of Negative_regulation (inhibition) of fatty acid amide hydrolase in neurons associated with qutenza
1) Confidence 0.43 Published 2006 Journal Eur. J. Neurosci. Section Title Doc Link 17229097 Disease Relevance 0.31 Pain Relevance 0.75
Considering the interaction that has been shown between the endogenous opioid and endocannabinoid systems in nociception processing, we studied the effects of URB597, a selective inhibitor of FAAH (fatty acid amide hydrolase), on modulation of nociception in a model of elevated endogenous opioid tone, cholestasis.
Regulation (effects) of Negative_regulation (inhibitor) of FAAH associated with nociception, endocannabinoid, endogenous opioid and gallstones
2) Confidence 0.42 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18593578 Disease Relevance 0.77 Pain Relevance 0.75
The data are consistent with the conclusion that the non-ionised forms of the acidic NSAIDs are responsible for the inhibition of fatty acid amide hydrolase.
Regulation (responsible) of Negative_regulation (inhibition) of fatty acid amide hydrolase associated with cinod
3) Confidence 0.37 Published 2003 Journal J Enzyme Inhib Med Chem Section Abstract Doc Link 12751821 Disease Relevance 0.14 Pain Relevance 0.35
The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats.
Regulation (effect) of Negative_regulation (inhibitor) of FAAH in medulla associated with locus ceruleus, antagonist, analgesic, serotonin and rostral ventromedial medulla
4) Confidence 0.34 Published 2008 Journal Neuropharmacology Section Title Doc Link 18616956 Disease Relevance 0.52 Pain Relevance 1.21
To address this question we compared the effects of local inhibition of FAAH versus COX2 (URB597 and nimesulide, respectively) on inflammatory hyperalgesia and levels of endocannabinoids and related molecules in the hindpaw.
Regulation (effects) of Negative_regulation (inhibition) of FAAH associated with endocannabinoid, hyperalgesia, inflammation and cox2
5) Confidence 0.21 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18534634 Disease Relevance 0.57 Pain Relevance 0.92
The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats.
Regulation (effect) of in locus coeruleus Negative_regulation (inhibitor) of FAAH in medulla associated with locus ceruleus, antagonist, analgesic, serotonin and rostral ventromedial medulla
6) Confidence 0.12 Published 2008 Journal Neuropharmacology Section Title Doc Link 18616956 Disease Relevance 0.52 Pain Relevance 1.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox