INT11052

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 16.66
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
NK cells 6
lung 6
T cell 6
blood 4
lymphocytes 4
CD69 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 104 99.64 Very High Very High Very High
cytokine 243 98.60 Very High Very High Very High
Inflammation 235 94.96 High High
Inflammatory mediators 10 93.48 High High
Opioid 1 86.80 High High
Osteoarthritis 14 83.76 Quite High
headache 12 81.76 Quite High
rheumatoid arthritis 35 74.28 Quite High
Inflammatory response 22 67.56 Quite High
depression 10 57.08 Quite High
Disease Link Frequency Relevance Heat
Cicatrix 166 99.84 Very High Very High Very High
Pulmonary Disease 435 99.80 Very High Very High Very High
Endometriosis 180 99.64 Very High Very High Very High
Nicotine Addiction 455 99.38 Very High Very High Very High
Cancer 84 98.52 Very High Very High Very High
Disease 61 97.20 Very High Very High Very High
INFLAMMATION 264 94.96 High High
Death 13 94.00 High High
Lymphocytosis 1 90.96 High High
Infection 83 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Neg (not) Positive_regulation (stimulate) of Gene_expression (expression) of CD69 in lymphocytes
1) Confidence 0.43 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.09
A decrease of CD25 antigen expression with a concomitant increase of CD69 expression has been observed in the endometrium according to the menstrual cycle changes [21].
Positive_regulation (increase) of Gene_expression (expression) of CD69 in endometrium
2) Confidence 0.37 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.14 Pain Relevance 0.24
Similarly, CD69 antigen expression was significantly higher in scar endometriosis than in the control group.
Positive_regulation (higher) of Gene_expression (expression) of CD69 associated with endometriosis and cicatrix
3) Confidence 0.37 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.94 Pain Relevance 0.58
The efficacy of stimulation, as evaluated by the expression level of the activation marker CD69, was comparable between week 0 and 12 (median MFI ?
Positive_regulation (evaluated) of Gene_expression (expression) of CD69
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.09 Pain Relevance 0.37
Thus, even though the CD107a data did not reach statistical significance, it supports the evidence of increased cytotoxic activity as indicated by increased expression of CD69.
Positive_regulation (increased) of Gene_expression (expression) of CD69
5) Confidence 0.34 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.15 Pain Relevance 0.03
At the 1:400 dilution, CD69 expression was increased by 32% (p < 0.05) for MTB, and by 36% for CW (p < 0.006).
Positive_regulation (increased) of Gene_expression (expression) of CD69
6) Confidence 0.34 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.27 Pain Relevance 0.03
Conversely, NK cell activation, demonstrated as an increase in CD69 expression, was nearly identical following MTB or CW treatment, across a broad dilution range.
Positive_regulation (increase) of Gene_expression (expression) of CD69 in NK cell
7) Confidence 0.34 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.77 Pain Relevance 0.25
Similarly, increased expression of MHC II, CD86, and CD69 molecules, but decreased CD62L levels, have also been observed in activated eosinophils after in vitro exposure to Strongyloides stercolaris antigens in a murine model [47].
Positive_regulation (increased) of Gene_expression (expression) of CD69 in CD86
8) Confidence 0.33 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.44 Pain Relevance 0
These results are supported by the increased expression of activation markers (CD69 and HLA-DR) on CD4+ and CD8+ T cells at symptom onset.
Positive_regulation (increased) of Gene_expression (expression) of CD69 in T cells
9) Confidence 0.29 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC3013083 Disease Relevance 0.59 Pain Relevance 0.28
Both MTB and CW showed a clear dose-dependent induction of the expression of CD69 on NK cells (Figure 4A).
Positive_regulation (induction) of Gene_expression (expression) of CD69 in NK cells
10) Confidence 0.24 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.25 Pain Relevance 0.03
Plasmid construction for the expression of recombinant LRP2 and CD69 molecules
Positive_regulation (construction) of Gene_expression (expression) of CD69
11) Confidence 0.24 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.05 Pain Relevance 0.16
CD69 and CD38 expression was high and similar between groups, consistent with immune activation.
Positive_regulation (high) of Gene_expression (expression) of CD69
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943484 Disease Relevance 0.65 Pain Relevance 0.03
Both MTB and CW induced the expression of the CD69 activation marker on human CD3- CD56+ NK cells, and enhanced the expression of CD107a when exposed to K562 tumor cells in vitro.
Positive_regulation (induced) of Gene_expression (expression) of CD69 in NK cells associated with cancer
13) Confidence 0.23 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC2858026 Disease Relevance 0.58 Pain Relevance 0.25
Moreover, compared to never-smokers, the expansion and activation of airway CD8+ lymphocytes, in terms of increased expression of CD69, HLA-DR and CD25, have been demonstrated in smokers without a clinical diagnosis of COPD (12).
Positive_regulation (increased) of Gene_expression (expression) of CD69 in lymphocytes associated with pulmonary disease and nicotine addiction
14) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.33 Pain Relevance 0.03
CD4+ and CD8+ T cell activation as measured by CD69 expression
Positive_regulation (measured) of Gene_expression (expression) of CD69 in T cell
15) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488375 Disease Relevance 0.06 Pain Relevance 0
We stimulated the whole blood of 3 volunteers with all 66 Ag85A peptides and monitored the proportion of CD4+ and CD8+ cells activated by upregulation of expression of CD69 (Table 3).
Positive_regulation (upregulation) of Gene_expression (expression) of CD69 in blood
16) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488375 Disease Relevance 0.21 Pain Relevance 0
CD4+ and CD8+ T cell activation as measured by CD69 expression
Positive_regulation (by) of Gene_expression (expression) of CD69 in T cell
17) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488375 Disease Relevance 0.06 Pain Relevance 0
In this study, we detected the expansion of CD8+CD69+ cells and the increased expression of the cell surface receptor CD69 on CD8+ T cells in both COPD and smokers with normal lung function, compared to never-smokers.
Positive_regulation (increased) of Gene_expression (expression) of CD69 in lung associated with nicotine addiction and pulmonary disease
18) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.51 Pain Relevance 0
Further, the proportions of CD69- and NKG2D-expressing cytotoxic T cells in BAL fluid were enhanced in both subjects with COPD and smokers with normal lung function and increased expression of CD69 was found on CD8+ cells, indicating the cigarette smoke exposure-induced expansion of activated cytotoxic T cells, which potentially can respond to stressed epithelial cells.



Positive_regulation (increased) of Gene_expression (expression) of CD69 in cytotoxic T cells associated with nicotine addiction and pulmonary disease
19) Confidence 0.18 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2955660 Disease Relevance 1.28 Pain Relevance 0
In addition, we now report that the cytotoxic T cells in BALF of smokers with normal lung function and COPD patients express high levels of the co-stimulatory receptor NKG2 D and the early cell activation marker CD69.
Positive_regulation (levels) of Gene_expression (express) of CD69 in lung associated with pulmonary disease and nicotine addiction
20) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.53 Pain Relevance 0

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