INT110521

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Context Info
Confidence 0.28
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.42
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crygb) cytoplasm (Crygb)
Anatomy Link Frequency
fat 1
brain 1
lung 1
Crygb (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 24 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
agonist 8 99.92 Very High Very High Very High
antidepressant 4 98.60 Very High Very High Very High
Acute pain 1 98.44 Very High Very High Very High
Morphine 5 97.08 Very High Very High Very High
Opioid 2 94.64 High High
tail-flick 2 82.84 Quite High
qutenza 8 77.04 Quite High
analgesia 3 75.36 Quite High
Disease Link Frequency Relevance Heat
Pain 7 98.44 Very High Very High Very High
Anxiety Disorder 5 96.68 Very High Very High Very High
Targeted Disruption 5 89.64 High High
Eating Disorder 1 89.04 High High
Shock 2 81.80 Quite High
Stress 1 65.04 Quite High
Depression 1 63.56 Quite High
Body Weight 2 45.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine.
Regulation (Effects) of NOP associated with pain, acute pain, orphanin, agonist and morphine
1) Confidence 0.28 Published 2008 Journal Eur. J. Pharmacol. Section Title Doc Link 18031727 Disease Relevance 0.65 Pain Relevance 1.53
The aim of this study was to investigate the role of the N/OFQ-NOP receptor system in bronchoconstriction induced by sensory nerve activation in the isolated mouse lung.
Spec (investigate) Regulation (role) of NOP in lung
2) Confidence 0.24 Published 2010 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 19448152 Disease Relevance 0 Pain Relevance 0.40
Conditioned place preference to high fat diet under food-deprived conditions was unaltered in NOP KO mice, suggesting no difference in reward responses.
Regulation (unaltered) of NOP in fat
3) Confidence 0.19 Published 2009 Journal Physiol. Behav. Section Abstract Doc Link 19138695 Disease Relevance 0.17 Pain Relevance 0.24
These findings support the NOP receptor as a candidate target for the development of innovative antidepressant drugs.
Regulation (target) of NOP receptor associated with antidepressant
4) Confidence 0.14 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12752799 Disease Relevance 0.42 Pain Relevance 0.39
Thus, the N/OFQ and NOP receptor are located in the central nervous systems in humans, primates, and rodents, and are involved in the integration of the emotional components in the brain; e.g., N/OFQ displays anxiolytic activity in the brain.
Regulation (involved) of NOP receptor in brain associated with anxiety disorder
5) Confidence 0.03 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19125610 Disease Relevance 0.18 Pain Relevance 0.36

General Comments

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