INT110538

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.80
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNK18)
Anatomy Link Frequency
spinal cord 2
trigeminal ganglion 1
KCNK18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 7 99.84 Very High Very High Very High
Spinal cord 10 99.68 Very High Very High Very High
trigeminal ganglion 1 98.44 Very High Very High Very High
local anesthetic 2 93.00 High High
Pain 1 87.20 High High
Potency 1 86.76 High High
potassium channel 6 85.76 High High
isoflurane 5 84.96 Quite High
halothane 2 83.68 Quite High
Central nervous system 1 82.08 Quite High
Disease Link Frequency Relevance Heat
Headache 3 99.84 Very High Very High Very High
Ganglion Cysts 1 98.00 Very High Very High Very High
Migraine With Aura 4 97.96 Very High Very High Very High
Pain 1 87.20 High High
Headache Disorders 1 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further characterization of TRESK expression patterns is needed to understand their role in anesthetic mechanisms.
Gene_expression (expression) of TRESK
1) Confidence 0.78 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16192517 Disease Relevance 0 Pain Relevance 0.47
Moreover, we confirmed that TRESK is expressed in the spinal cord.
Gene_expression (expressed) of TRESK in spinal cord associated with spinal cord
2) Confidence 0.75 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12754259 Disease Relevance 0 Pain Relevance 0.21
We also identified prominent TRESK expression in migraine-salient areas such as the trigeminal ganglion.
Gene_expression (expression) of TRESK in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and migraine
3) Confidence 0.67 Published 2010 Journal Nat. Med. Section Abstract Doc Link 20871611 Disease Relevance 0.80 Pain Relevance 0.98
We also determined that TRESK is found not only in spinal cord, but also in human brain RNA.
Gene_expression (found) of TRESK in spinal cord associated with spinal cord
4) Confidence 0.60 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15562060 Disease Relevance 0 Pain Relevance 0.40

General Comments

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