INT110545

Context Info Confidence 0.42 First Reported 2003 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 7 Total Number 8 Disease Relevance 1.68 Pain Relevance 5.67

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) signal transducer activity (OPRM1)

Anatomy Link Frequency embryonic kidney 2 OPRM1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 40 100.00 mu opioid receptor 29 100.00 agonist 7 100.00 Potency 4 100.00 narcan 4 99.44 analgesia 3 98.08 anesthesia 2 97.52 Morphine 15 97.44 antagonist 2 96.78 Opioid 19 96.56

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 4 99.84 Reprotox - General 2 1 95.64 Cancer 5 93.52 Necrosis 5 93.04 Opiate Addiction 1 91.36 Neuroblastoma 4 75.00 Skin Cancer 2 58.12 Inflammatory Pain 1 52.20 INFLAMMATION 2 49.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

An allelic variation within the -557 element significantly reduced its trans-activating potency, which may affect regulation of the mu-opioid receptor gene in persons carrying this mutation.

Regulation (affect) of Regulation (regulation) of mu-opioid receptor gene associated with opioid receptor and potency

1) Confidence 0.42 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14500744 Disease Relevance 0.80 Pain Relevance 0.55

Therefore, in the present study we have investigated whether this mutation might affect the binding affinity, potency, and/or the agonist-induced desensitization, internalization and resensitization of the human mu-opioid receptor stably expressed in human embryonic kidney 293 cells.

Spec (might) Regulation (affect) of Regulation (resensitization) of mu-opioid receptor in embryonic kidney associated with agonist, opioid receptor and potency

2) Confidence 0.37 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15086512 Disease Relevance 0.19 Pain Relevance 1.01

These results indicate that re-initiation in MOR gene expression could play an important role in OPRM1 regulation.

Regulation (role) of Regulation (regulation) of OPRM1 associated with mu opioid receptor

3) Confidence 0.27 Published 2010 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19438807 Disease Relevance 0 Pain Relevance 0.39

Those promoter elements were involved in the transcriptional regulation of the mu opioid receptor gene.

Regulation (involved) of Regulation (regulation) of mu opioid receptor associated with mu opioid receptor

4) Confidence 0.27 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15988758 Disease Relevance 0 Pain Relevance 0.57

In conclusion, transcriptional regulation of MOR1 is modified by two genetic variations at positions -554 and -1320 of the mu-opioid receptor promoter.

Regulation (modified) of Regulation (regulation) of MOR1 associated with opioid receptor

5) Confidence 0.26 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16843022 Disease Relevance 0.06 Pain Relevance 0.58

Variations in the 5' flanking sequence of the mu-opioid receptor gene may influence transcriptional regulation and ultimately alter protein expression of MOR1.

Regulation (influence) of Regulation (regulation) of mu-opioid receptor gene associated with opioid receptor

6) Confidence 0.26 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16843022 Disease Relevance 0.07 Pain Relevance 0.64

An opioid antagonist, naloxone, reversed the morphine and endomorphin-1 and -2 effects on MOR mRNA levels in undifferentiated SHSY-5Y cells, but naloxone had differential reversing effects on the agonists' regulation of MOR mRNA in RA- or TPA-differentiated cells.

Regulation (effects) of Regulation (regulation) of MOR mRNA associated with antagonist, rheumatoid arthritis, agonist, narcan, opioid receptor, opioid and morphine

7) Confidence 0.26 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12754318 Disease Relevance 0.50 Pain Relevance 1.31

It is postulated that the observed effects on mu opioid receptor regulation by filamin A and, by implication, of the actin cytoskeleton may be the result of its role in mu opioid receptor trafficking.

Regulation (effects) of Regulation (regulation) of mu opioid receptor associated with mu opioid receptor

8) Confidence 0.23 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573758 Disease Relevance 0.06 Pain Relevance 0.62

General Comments

This test has worked.