INT110545

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.68
Pain Relevance 5.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
embryonic kidney 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 40 100.00 Very High Very High Very High
mu opioid receptor 29 100.00 Very High Very High Very High
agonist 7 100.00 Very High Very High Very High
Potency 4 100.00 Very High Very High Very High
narcan 4 99.44 Very High Very High Very High
analgesia 3 98.08 Very High Very High Very High
anesthesia 2 97.52 Very High Very High Very High
Morphine 15 97.44 Very High Very High Very High
antagonist 2 96.78 Very High Very High Very High
Opioid 19 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 4 99.84 Very High Very High Very High
Reprotox - General 2 1 95.64 Very High Very High Very High
Cancer 5 93.52 High High
Necrosis 5 93.04 High High
Opiate Addiction 1 91.36 High High
Neuroblastoma 4 75.00 Quite High
Skin Cancer 2 58.12 Quite High
Inflammatory Pain 1 52.20 Quite High
INFLAMMATION 2 49.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An allelic variation within the -557 element significantly reduced its trans-activating potency, which may affect regulation of the mu-opioid receptor gene in persons carrying this mutation.
Regulation (affect) of Regulation (regulation) of mu-opioid receptor gene associated with opioid receptor and potency
1) Confidence 0.42 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14500744 Disease Relevance 0.80 Pain Relevance 0.55
Therefore, in the present study we have investigated whether this mutation might affect the binding affinity, potency, and/or the agonist-induced desensitization, internalization and resensitization of the human mu-opioid receptor stably expressed in human embryonic kidney 293 cells.
Spec (might) Regulation (affect) of Regulation (resensitization) of mu-opioid receptor in embryonic kidney associated with agonist, opioid receptor and potency
2) Confidence 0.37 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15086512 Disease Relevance 0.19 Pain Relevance 1.01
These results indicate that re-initiation in MOR gene expression could play an important role in OPRM1 regulation.
Regulation (role) of Regulation (regulation) of OPRM1 associated with mu opioid receptor
3) Confidence 0.27 Published 2010 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19438807 Disease Relevance 0 Pain Relevance 0.39
Those promoter elements were involved in the transcriptional regulation of the mu opioid receptor gene.
Regulation (involved) of Regulation (regulation) of mu opioid receptor associated with mu opioid receptor
4) Confidence 0.27 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15988758 Disease Relevance 0 Pain Relevance 0.57
In conclusion, transcriptional regulation of MOR1 is modified by two genetic variations at positions -554 and -1320 of the mu-opioid receptor promoter.
Regulation (modified) of Regulation (regulation) of MOR1 associated with opioid receptor
5) Confidence 0.26 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16843022 Disease Relevance 0.06 Pain Relevance 0.58
Variations in the 5' flanking sequence of the mu-opioid receptor gene may influence transcriptional regulation and ultimately alter protein expression of MOR1.
Regulation (influence) of Regulation (regulation) of mu-opioid receptor gene associated with opioid receptor
6) Confidence 0.26 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16843022 Disease Relevance 0.07 Pain Relevance 0.64
An opioid antagonist, naloxone, reversed the morphine and endomorphin-1 and -2 effects on MOR mRNA levels in undifferentiated SHSY-5Y cells, but naloxone had differential reversing effects on the agonists' regulation of MOR mRNA in RA- or TPA-differentiated cells.
Regulation (effects) of Regulation (regulation) of MOR mRNA associated with antagonist, rheumatoid arthritis, agonist, narcan, opioid receptor, opioid and morphine
7) Confidence 0.26 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12754318 Disease Relevance 0.50 Pain Relevance 1.31
It is postulated that the observed effects on mu opioid receptor regulation by filamin A and, by implication, of the actin cytoskeleton may be the result of its role in mu opioid receptor trafficking.
Regulation (effects) of Regulation (regulation) of mu opioid receptor associated with mu opioid receptor
8) Confidence 0.23 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573758 Disease Relevance 0.06 Pain Relevance 0.62

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