INT110550

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.59
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C8) endoplasmic reticulum (CYP2C8)
CYP2C8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 99.48 Very High Very High Very High
methadone 15 98.12 Very High Very High Very High
Taxol 1 86.60 High High
Inflammation 33 80.72 Quite High
antagonist 8 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 5 99.96 Very High Very High Very High
Breast Cancer 3 98.96 Very High Very High Very High
Cancer 116 90.96 High High
Biliary Cancer 1 88.00 High High
INFLAMMATION 33 80.72 Quite High
Cardiovascular Disease 3 79.36 Quite High
Ovarian Cancer 3 56.80 Quite High
Cholangiocarcinoma 1 55.64 Quite High
Seminoma 1 54.84 Quite High
Hepatocellular Cancer 2 37.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More than 90% of morphine N-demethylation could be accounted for via the action of both CYP3A4 and CYP2C8. 4.
Regulation (accounted) of CYP2C8 associated with morphine
1) Confidence 0.45 Published 2003 Journal Xenobiotica Section Abstract Doc Link 12936704 Disease Relevance 0 Pain Relevance 0.41
Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro.
Regulation (Involvement) of CYP2C8 associated with methadone
2) Confidence 0.27 Published 2003 Journal Drug Metab. Dispos. Section Title Doc Link 12756206 Disease Relevance 0 Pain Relevance 0.85
Recent studies have implicated that genetic polymorphisms in CYP2C8 and CYP2C9 influence disease-free survival in breast cancer patients [132].
Regulation (influence) of CYP2C8 associated with breast cancer and disease
3) Confidence 0.14 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.59 Pain Relevance 0.08

General Comments

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