INT110559

Context Info Confidence 0.04 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.19 Pain Relevance 0

endosome (Tlr7) signal transduction (Tlr7) endoplasmic reticulum (Tlr7) plasma membrane (Tlr7) intracellular (Tlr7) lysosome (Tlr7)

Tlr7 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 1 48.24

Disease Link Frequency Relevance Heat Papillomavirus Infection 1 70.32 Recurrence 2 63.44 Non-genital Cutaneous Warts 2 35.44 Pox Virus Infection 1 33.60 Leishmaniasis 1 31.52 Hypopigmentation 1 25.00 Alopecia Areata 1 25.00 Granuloma Annulare 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The reported TLR-7 activation to provoke an immune response suggests that imiquimod might mimic a microbial antigen.

Positive_regulation (activation) of TLR-7

1) Confidence 0.04 Published 2003 Journal Dermatol Clin Section Abstract Doc Link 12757252 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.