INT110564

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.82
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hprt) transferase activity, transferring glycosyl groups (Hprt) cytoplasm (Hprt)
Hprt (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 16 75.44 Quite High
Morphine 6 50.00 Quite Low
cerebral cortex 1 15.24 Low Low
narcan 3 10.00 Low Low
Dopamine 5 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 6 94.24 High High
Syndrome 9 93.40 High High
Hyperuricemia 20 81.60 Quite High
Disease 102 77.28 Quite High
Congenital Anomalies 18 61.44 Quite High
Cognitive Disorder 36 60.88 Quite High
Glioma 6 55.28 Quite High
Kidney Stones 3 54.52 Quite High
Neurologic Manifestations 3 47.76 Quite Low
Rare Diseases 1 34.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have identified a number of HPRT mutations in Asian patients manifesting different clinical phenotypes, by analyzing all nine exons of the HPRT gene (HPRT1) from genomic DNA and reverse-transcribed mRNA using the PCR technique coupled with direct sequencing.
Transcription (transcribed) of HPRT gene
1) Confidence 0.37 Published 2007 Journal Mol. Genet. Metab. Section Abstract Doc Link 17027311 Disease Relevance 0.27 Pain Relevance 0.15
Another shortcoming is that mutation screening will miss the unusual cases of HPRT deficiency that are due to non-coding reductions in HPRT mRNA expression (Dawson et al., 2005; Garcia et al., 2008).
Transcription (expression) of HPRT
2) Confidence 0.37 Published 2010 Journal Brain Section Body Doc Link PMC2842514 Disease Relevance 0.50 Pain Relevance 0
The levels of transcript of HGPRT mRNA were lower in the morphine group than in the control group at all time points after treatment.
Transcription (transcript) of HGPRT
3) Confidence 0.33 Published 2003 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 12757645 Disease Relevance 0.06 Pain Relevance 0
However, the level of transcript of HGPRT mRNA 72 hours after treatment was higher in the morphine group than in the control group.
Transcription (transcript) of HGPRT
4) Confidence 0.24 Published 2003 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 12757645 Disease Relevance 0 Pain Relevance 0
The level of transcript of HGPRT mRNA 24 hours after exposure to morphine in the naloxon2 + morphine group was still lower than in the control group.
Transcription (transcript) of HGPRT
5) Confidence 0.24 Published 2003 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 12757645 Disease Relevance 0 Pain Relevance 0

General Comments

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