INT110568

Context Info Confidence 0.49 First Reported 2003 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 9 Disease Relevance 5.14 Pain Relevance 0.09

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH) peroxisome (XDH) cytoplasm (XDH)

Anatomy Link Frequency grid 2 XDH (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 5 98.80 ischemia 10 73.76 Morphine 2 50.00 narcan 1 10.00 Bioavailability 3 6.48 endometriosis 84 5.00 cytokine 40 5.00 Inflammation 16 5.00 headache 12 5.00 alcohol 10 5.00

Disease Link Frequency Relevance Heat Reperfusion Injury 6 99.98 Hypoxia 17 99.60 Infarction 3 99.08 Fibrosis 5 98.80 Hypertrophy 3 98.40 Stress 286 98.24 Myocardial Infarction 44 95.56 Eclampsia 40 89.80 Hypertension 24 83.44 Diabetes Mellitus 18 82.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Once again, XO expression (as determined by electron spin resonance spectroscopy) and myocardial ROS generation were markedly increased in the post-mycardial infarction ischemic model.44 This suggests a role for allopurinol in LV remodeling, a possibility that we are investigating at present in our unit.

Positive_regulation (increased) of Gene_expression (expression) of XO associated with infarction

1) Confidence 0.49 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.81 Pain Relevance 0.05

Naloxone reverses the effect of morphine on enhancement of XD/XO gene expression and cannot reverse the inhibitory effect of morphine on HGPRT and AK gene expression.

Positive_regulation (enhancement) of Gene_expression (expression) of XD

2) Confidence 0.45 Published 2003 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 12757645 Disease Relevance 0 Pain Relevance 0

XOR is synthesized as XDH, which in mammals can easily be converted to XO by oxidation of sulfhydryl residues or by proteolysis (Okamoto et al 2003).

Positive_regulation (converted) of Gene_expression (converted) of XDH

3) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.24 Pain Relevance 0

XOR is the only enzyme capable of catalyzing the formation of urate in man.25 In lower mammals, an enzyme, urate oxidase further metabolizes uric acid to allantoin but this enzyme is inactivated in primates.26 There is also a suggestion from teleological studies that urate may have even evolved as a compensatory mechanism in higher primates that have lost the capacity to generate other antioxidants like ascorbate in vivo.27

Positive_regulation (inactivated) of Gene_expression (enzyme) of XOR

4) Confidence 0.40 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.06 Pain Relevance 0

XOR is synthesized as XDH, which in mammals can easily be converted to XO by oxidation of sulfhydryl residues or by proteolysis (Okamoto et al 2003).

Positive_regulation (converted) of Gene_expression (converted) of XO

5) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.24 Pain Relevance 0

There is a large variability in human XOR expression which can be up to three-fold and on average 20% higher in men than in women.29 Although basal expression of XOR is low in humans, hypoxia, IL-1, IL-6, TNF-?

Positive_regulation (variability) of Gene_expression (expression) of XOR associated with hypoxia

6) Confidence 0.35 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.38 Pain Relevance 0.04

The inefficiency increases with the size of the grid; for example an XOR-grid of a million elements is needed to generate 1000 bits of integrated information. ?

Positive_regulation (generate) of Gene_expression (generate) of XOR-grid in grid

7) Confidence 0.30 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0

The hypoxia/reperfusion injury leads to increased expression of xanthine oxidase and NADP (H) oxidase and resultant increased generation of superoxide anion.

Positive_regulation (leads) of Gene_expression (expression) of xanthine oxidase associated with reperfusion injury and hypoxia

8) Confidence 0.16 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 1.74 Pain Relevance 0

The hypoxia/reperfusion injury leads to increased expression of xanthine oxidase and NADP (H) oxidase and resultant increased generation of superoxide anion.

Positive_regulation (increased) of Gene_expression (expression) of xanthine oxidase associated with reperfusion injury and hypoxia

9) Confidence 0.11 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 1.68 Pain Relevance 0

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