INT110568
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Once again, XO expression (as determined by electron spin resonance spectroscopy) and myocardial ROS generation were markedly increased in the post-mycardial infarction ischemic model.44 This suggests a role for allopurinol in LV remodeling, a possibility that we are investigating at present in our unit. | |||||||||||||||
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Naloxone reverses the effect of morphine on enhancement of XD/XO gene expression and cannot reverse the inhibitory effect of morphine on HGPRT and AK gene expression.
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XOR is synthesized as XDH, which in mammals can easily be converted to XO by oxidation of sulfhydryl residues or by proteolysis (Okamoto et al 2003). | |||||||||||||||
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XOR is the only enzyme capable of catalyzing the formation of urate in man.25 In lower mammals, an enzyme, urate oxidase further metabolizes uric acid to allantoin but this enzyme is inactivated in primates.26 There is also a suggestion from teleological studies that urate may have even evolved as a compensatory mechanism in higher primates that have lost the capacity to generate other antioxidants like ascorbate in vivo.27 | |||||||||||||||
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XOR is synthesized as XDH, which in mammals can easily be converted to XO by oxidation of sulfhydryl residues or by proteolysis (Okamoto et al 2003). | |||||||||||||||
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There is a large variability in human XOR expression which can be up to three-fold and on average 20% higher in men than in women.29 Although basal expression of XOR is low in humans, hypoxia, IL-1, IL-6, TNF-? | |||||||||||||||
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The inefficiency increases with the size of the grid; for example an XOR-grid of a million elements is needed to generate 1000 bits of integrated information. ? | |||||||||||||||
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The hypoxia/reperfusion injury leads to increased expression of xanthine oxidase and NADP (H) oxidase and resultant increased generation of superoxide anion. | |||||||||||||||
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The hypoxia/reperfusion injury leads to increased expression of xanthine oxidase and NADP (H) oxidase and resultant increased generation of superoxide anion. | |||||||||||||||
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