INT110569

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 18.35
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH)
peroxisome (XDH) cytoplasm (XDH)
Anatomy Link Frequency
grid 3
endothelial cells 2
muscle 2
neuronal 1
liver 1
XDH (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 5 99.26 Very High Very High Very High
ischemia 48 99.00 Very High Very High Very High
fibrosis 13 98.80 Very High Very High Very High
dexamethasone 14 97.56 Very High Very High Very High
adenocard 60 92.00 High High
cytokine 51 73.84 Quite High
Inflammation 71 60.44 Quite High
Dysuria 1 57.04 Quite High
Morphine 4 50.00 Quite Low
carrageenan induced 1 47.68 Quite Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 12 99.94 Very High Very High Very High
Injury 90 99.70 Very High Very High Very High
Reperfusion Injury 13 99.60 Very High Very High Very High
Viral Infection 19 99.58 Very High Very High Very High
Hypoxia 36 99.24 Very High Very High Very High
Stress 468 99.12 Very High Very High Very High
Cv Unclassified Under Development 46 99.00 Very High Very High Very High
Fibrosis 13 98.80 Very High Very High Very High
Hypertrophy 10 98.40 Very High Very High Very High
Hypertension 71 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
XOR is highly expressed in the liver for purine catabolism.
Gene_expression (expressed) of XOR in liver
1) Confidence 0.75 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.34 Pain Relevance 0
Finally, the concentration of xanthine oxidase products (superoxide and uric acid) in the supernatant of endothelial cells cultured with elastase was significantly reduced by the addition of carbocisteine to the culture.
Gene_expression (products) of xanthine oxidase in endothelial cells
2) Confidence 0.65 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650606 Disease Relevance 0.27 Pain Relevance 0.05
ROS may contribute to tissue damage in some viral infections such as influenza.9 XOR exists in two forms: xanthine dehydrogenase (XD; EC 1.1.1.204) and xanthine oxidase (XO; EC 1.1.3.22).
Gene_expression (exists) of xanthine dehydrogenase associated with influenza virus infection and viral infection
3) Confidence 0.65 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.29 Pain Relevance 0.03
ROS may contribute to tissue damage in some viral infections such as influenza.9 XOR exists in two forms: xanthine dehydrogenase (XD; EC 1.1.1.204) and xanthine oxidase (XO; EC 1.1.3.22).
Gene_expression (exists) of xanthine oxidase associated with influenza virus infection and viral infection
4) Confidence 0.65 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.31 Pain Relevance 0.03
XOR is synthesized as XDH, which in mammals can easily be converted to XO by oxidation of sulfhydryl residues or by proteolysis (Okamoto et al 2003).
Gene_expression (synthesized) of XDH
5) Confidence 0.64 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.24 Pain Relevance 0
XOR is synthesized as XDH, which in mammals can easily be converted to XO by oxidation of sulfhydryl residues or by proteolysis (Okamoto et al 2003).
Gene_expression (synthesized) of XOR
6) Confidence 0.64 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.24 Pain Relevance 0
There is a large variability in human XOR expression which can be up to three-fold and on average 20% higher in men than in women.29 Although basal expression of XOR is low in humans, hypoxia, IL-1, IL-6, TNF-?
Gene_expression (expression) of XOR associated with hypoxia
7) Confidence 0.62 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.42 Pain Relevance 0.04
Naloxone reverses the effect of morphine on enhancement of XD/XO gene expression and cannot reverse the inhibitory effect of morphine on HGPRT and AK gene expression.


Gene_expression (expression) of XD
8) Confidence 0.58 Published 2003 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 12757645 Disease Relevance 0 Pain Relevance 0
The upregulation effect of morphine on the gene expression of XD/XO may be mediated by mu receptor.
Gene_expression (expression) of XD
9) Confidence 0.58 Published 2003 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 12757645 Disease Relevance 0 Pain Relevance 0
The aim of the present study was to investigate the serum levels of ADA-2 (the main source of ADA activity in the serum, which plays crucial roles in immune function) and xanthine oxidase (which increases tissue damage via the formation of free oxygen radicals) in CCHF patients and to compare the results with those obtained for healthy controls.
Gene_expression (source) of xanthine oxidase associated with fever
10) Confidence 0.58 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 0.92 Pain Relevance 0.05
The aim of the present study was to investigate the serum levels of ADA-2 (the main source of ADA activity in the serum, which plays crucial roles in immune function) and xanthine oxidase (which increases tissue damage via the formation of free oxygen radicals) in CCHF patients and to compare the results with those obtained for healthy controls.
Spec (investigate) Gene_expression (levels) of xanthine oxidase associated with fever
11) Confidence 0.58 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 0.93 Pain Relevance 0.05
ROS may contribute to tissue damage in some viral infections such as influenza.9 XOR exists in two forms: xanthine dehydrogenase (XD; EC 1.1.1.204) and xanthine oxidase (XO; EC 1.1.3.22).
Gene_expression (exists) of XOR associated with influenza virus infection and viral infection
12) Confidence 0.56 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.23 Pain Relevance 0.03
XOR is synthesized as XDH, which in mammals can easily be converted to XO by oxidation of sulfhydryl residues or by proteolysis (Okamoto et al 2003).
Gene_expression (converted) of XDH
13) Confidence 0.55 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.24 Pain Relevance 0
There is a large variability in human XOR expression which can be up to three-fold and on average 20% higher in men than in women.29 Although basal expression of XOR is low in humans, hypoxia, IL-1, IL-6, TNF-?
Gene_expression (expression) of XOR associated with hypoxia
14) Confidence 0.54 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.38 Pain Relevance 0.04
Therefore XO production may not necessarily be reflected by systemic levels of XO metabolites.41

The XO inhibitor allopurinol

Gene_expression (production) of XO
15) Confidence 0.54 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.62 Pain Relevance 0
The effects were not seen in endothelial NOS deficient mice, suggesting a role for neuronal NOS preventing XO inhibition of cardiac excitation-contraction coupling.80 The finding that allopurinol is a potent myofilament Ca2+ sensitizer, particularly in the setting of ischemia, is thought to be due to the inhibition of basal XO production.
Gene_expression (production) of XO in neuronal associated with ischemia
16) Confidence 0.54 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.35 Pain Relevance 0.05
Once again, XO expression (as determined by electron spin resonance spectroscopy) and myocardial ROS generation were markedly increased in the post-mycardial infarction ischemic model.44 This suggests a role for allopurinol in LV remodeling, a possibility that we are investigating at present in our unit.
Gene_expression (expression) of XO associated with infarction
17) Confidence 0.54 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.75 Pain Relevance 0.05
XOR is the only enzyme capable of catalyzing the formation of urate in man.25 In lower mammals, an enzyme, urate oxidase further metabolizes uric acid to allantoin but this enzyme is inactivated in primates.26 There is also a suggestion from teleological studies that urate may have even evolved as a compensatory mechanism in higher primates that have lost the capacity to generate other antioxidants like ascorbate in vivo.27
Gene_expression (enzyme) of XOR
18) Confidence 0.54 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.06 Pain Relevance 0
XOR is synthesized as XDH, which in mammals can easily be converted to XO by oxidation of sulfhydryl residues or by proteolysis (Okamoto et al 2003).
Gene_expression (converted) of XO
19) Confidence 0.48 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643102 Disease Relevance 0.24 Pain Relevance 0
Therefore XO production may not necessarily be reflected by systemic levels of XO metabolites.41

The XO inhibitor allopurinol

Gene_expression (levels) of XO
20) Confidence 0.47 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.68 Pain Relevance 0

General Comments

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