INT11057

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Context Info
Confidence 0.94
First Reported 1985
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.34
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
VSMC 4
brain 2
bridge 1
mesenteric artery 1
hearts 1
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 11 99.80 Very High Very High Very High
Analgesic 2 94.88 High High
ischemia 2 93.20 High High
lidocaine 5 88.84 High High
Opioid 2 88.32 High High
anesthesia 1 80.24 Quite High
addiction 1 60.24 Quite High
Somatostatin 2 25.00 Low Low
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Natriuresis 33 100.00 Very High Very High Very High
Myocardial Infarction 5 98.50 Very High Very High Very High
Cv Unclassified Under Development 2 93.20 High High
Acute Renal Failure 6 91.84 High High
Obesity 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rat kidney membranes degraded ANF into biologically inactive forms.
Protein_catabolism (degraded) of ANF in kidney
1) Confidence 0.94 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2973321 Disease Relevance 0.17 Pain Relevance 0.10
The neutral endopeptidase 24.11 (NEP) also called 'enkephalinase' thanks to its inactivation of enkephalins in the brain, was also recently shown to be involved in the degradation of the circulating atrial natriuretic peptide (ANP).
Protein_catabolism (degradation) of ANP in brain associated with natriuresis and enkephalin
2) Confidence 0.87 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1882086 Disease Relevance 0.10 Pain Relevance 0.28
The neutral endopeptidase 24.11 (NEP) also called 'enkephalinase' thanks to its inactivation of enkephalins in the brain, was also recently shown to be involved in the degradation of the circulating atrial natriuretic peptide (ANP).
Protein_catabolism (degradation) of atrial natriuretic peptide in brain associated with natriuresis and enkephalin
3) Confidence 0.87 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1882086 Disease Relevance 0.10 Pain Relevance 0.28
The high performance liquid chromatography method used to follow the degradation of atrial natriuretic peptide differed from previously published procedures, in that samples to be injected were first treated with excess dithiothreitol to reduce the Cys7-Cys23 disulfide bridge.
Protein_catabolism (degradation) of atrial natriuretic peptide in bridge associated with natriuresis
4) Confidence 0.79 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1533267 Disease Relevance 0.53 Pain Relevance 0.17
Because an endopeptidase-24.11-like activity has recently been reported in the rat mesenteric artery, we have further investigated the degradation of atrial natriuretic peptide in vascular tissue.
Spec (investigated) Protein_catabolism (degradation) of atrial natriuretic peptide in mesenteric artery associated with natriuresis
5) Confidence 0.79 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1533267 Disease Relevance 0.48 Pain Relevance 0.14
OBJECTIVE: Increased secretion of atrial and brain natriuretic peptide (ANP and BNP) from hearts is known to exhibit favorable effects in patients and animals with heart failure, and inhibition of neutral endopeptidase (NEP), an enzyme that degrades ANP and BNP, may further increase these peptide levels.
Protein_catabolism (degrades) of ANP in hearts associated with natriuresis and myocardial infarction
6) Confidence 0.74 Published 2001 Journal Cardiovasc. Res. Section Abstract Doc Link 11476752 Disease Relevance 0.52 Pain Relevance 0
Binding, internalization, and degradation of atrial natriuretic peptide in cultured vascular smooth muscle cells of rat.
Protein_catabolism (degradation) of atrial natriuretic peptide in smooth muscle cells associated with natriuresis
7) Confidence 0.58 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2866767 Disease Relevance 0.20 Pain Relevance 0.06
These data indicate that rANP, after binding to the cell-surface receptors, is rapidly internalized into the cells through receptor-mediated endocytosis, and subsequently degradaded by lysosomal hydrolases.
Protein_catabolism (degradaded) of rANP
8) Confidence 0.58 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2866767 Disease Relevance 0.13 Pain Relevance 0.09
Neutral endopeptidase (NEP, 24.11) is an ectoenzyme involved in the degradation of peptide hormones such as endothelin (ET), atrial natriuretic factor and enkephalins.
Protein_catabolism (degradation) of atrial natriuretic factor associated with natriuresis and enkephalin
9) Confidence 0.53 Published 1999 Journal Mol. Cell. Biochem. Section Abstract Doc Link 10485324 Disease Relevance 0.60 Pain Relevance 0.26
Binding, internalization, and degradation of 125I-labeled-rat atrial natriuretic peptide (rANP) were studied in cultured rat aortic vascular smooth muscle cells (VSMC).
Protein_catabolism (degradation) of atrial natriuretic peptide in VSMC associated with natriuresis
10) Confidence 0.51 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2866767 Disease Relevance 0.17 Pain Relevance 0
The cell-bound 125I-labeled-rANP at 37 degrees C is rapidly dissociated from VSMC (t 1/2: approximately 40 min) with the appearance of degradaded product(s) of radioligand in the medium, whereas the degradation was minimal at 4 degrees C.
Protein_catabolism (degradation) of rANP in VSMC
11) Confidence 0.51 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2866767 Disease Relevance 0.16 Pain Relevance 0.08
Binding, internalization, and degradation of 125I-labeled-rat atrial natriuretic peptide (rANP) were studied in cultured rat aortic vascular smooth muscle cells (VSMC).
Protein_catabolism (degradation) of rANP in VSMC associated with natriuresis
12) Confidence 0.51 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2866767 Disease Relevance 0.17 Pain Relevance 0

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