INT110579

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 12.80
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
lymph node 2
epithelial cells 2
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 18 98.80 Very High Very High Very High
antagonist 20 87.44 High High
substance P 53 86.32 High High
metalloproteinase 42 83.04 Quite High
Opioid 1 70.08 Quite High
agonist 7 53.20 Quite High
Chronic pancreatitis 1 43.28 Quite Low
cytokine 28 25.00 Low Low
Spinal cord 3 22.88 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 117 100.00 Very High Very High Very High
Prostate Cancer 359 99.72 Very High Very High Very High
Malignant Neoplastic Disease 42 99.08 Very High Very High Very High
Recurrence 70 99.00 Very High Very High Very High
Cancer 881 98.96 Very High Very High Very High
Disease 99 97.64 Very High Very High Very High
Pancreatic Cancer 9 96.84 Very High Very High Very High
Benign Prostatic Hypertrophy 8 95.48 Very High Very High Very High
Metastasis 251 95.20 Very High Very High Very High
Thyroid Neoplasm 7 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A high percentage of prostate tumors show an early loss of CD10 expression [1,11].
Negative_regulation (loss) of Gene_expression (expression) of CD10 associated with prostate cancer
1) Confidence 0.58 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.47 Pain Relevance 0.03
Albrecht et al. [19] have reported a shift from membrane bound to cytoplasmic localization for CD10 in high-grade prostate cancer cells with a loss of CD10 expression in areas of high proliferative activity as indicated by Ki67 immunohistochemistry (n = 24, with perhaps around 7 containing CD10+ cancer cells based on their frequency).
Negative_regulation (loss) of Gene_expression (expression) of CD10 associated with cancer and prostate cancer
2) Confidence 0.58 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.85 Pain Relevance 0
Loss of CD10 expression by metastatic prostate cancer was first reported to contribute to androgen independent tumor growth [4].
Negative_regulation (Loss) of Gene_expression (expression) of CD10 associated with cancer and prostate cancer
3) Confidence 0.58 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.95 Pain Relevance 0.13
In contrast to our results, Osman et al. propose that loss of CD10 expression is associated with an unfavorable patient outcome.
Negative_regulation (loss) of Gene_expression (expression) of CD10
4) Confidence 0.58 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.43 Pain Relevance 0
Tawfic et al. [12] reported an absence of CD10 expression by Gleason grade 2 and 3 tumors however noted high expression of cytoplasmic and membranous CD10 in high Gleason tumors.
Negative_regulation (absence) of Gene_expression (expression) of CD10 associated with cancer
5) Confidence 0.58 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.54 Pain Relevance 0
This group found that complete loss of CD10 expression was associated with PSA recurrence after RP.
Negative_regulation (loss) of Gene_expression (expression) of CD10 associated with recurrence
6) Confidence 0.58 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.38 Pain Relevance 0
Met-enkephalin (10(-6) M) increased and thiorphan (2.5 x 10(-6)-10(-6) M) decreased expression of CD10 at the RNA level.
Negative_regulation (decreased) of Gene_expression (expression) of CD10 associated with enkephalin
7) Confidence 0.57 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12757739 Disease Relevance 0.07 Pain Relevance 0.74
NEP expression levels (Figure 3B) decreased twofold in CCRCC and thirtyfold in RO.
Negative_regulation (decreased) of Gene_expression (expression) of NEP
8) Confidence 0.51 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.56 Pain Relevance 0
Loss of CD10 expression is a common, early event in human prostate cancer; however, CD10 positive cancer cells frequently appear in lymph node metastasis.
Negative_regulation (Loss) of Gene_expression (expression) of CD10 in lymph node associated with cancer, prostate cancer and metastasis
9) Confidence 0.43 Published 2007 Journal BMC Urol Section Abstract Doc Link PMC1829163 Disease Relevance 0.71 Pain Relevance 0
Thus, DPP IV relative expression (Figure 3A) decreased fortysixfold in chromophobe RCCs, whereas NEP mRNA levels (Figure 3B) decreased sixtysevenfold in the same tumor-type.
Negative_regulation (decreased) of Gene_expression (levels) of NEP mRNA associated with cancer and renal cancer
10) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.67 Pain Relevance 0
Loss or decrease in NEP/CD10 expression have been reported in many types of malignancies, but the role of NEP/CD10 in pancreatic carcinoma has not yet been identified.
Negative_regulation (decrease) of Gene_expression (expression) of CD10 associated with pancreatic cancer
11) Confidence 0.42 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17294442 Disease Relevance 0.62 Pain Relevance 0
Thus, the relative expression of DPP4 (DPP IV transcriptome) and MME (NEP transcriptome) genes were found to be strongly decreased in ChRCC samples (DPP IV: ?
Negative_regulation (decreased) of Gene_expression (expression) of NEP
12) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.58 Pain Relevance 0
Finally, our results showing NEP mRNA expression are also consistent with previous studies reporting a strong expression of NEP in human bronchi [50].
Negative_regulation (reporting) of Gene_expression (expression) of NEP
13) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0 Pain Relevance 0.14
Usmani et al., reported that NEP expression was down-regulated in advanced prostate cancer cell lines PC-3 and DU145 compared to LNCaP and normal immortalized prostate epithelial cells [106].
Negative_regulation (down) of Gene_expression (expression) of NEP in epithelial cells associated with prostate cancer
14) Confidence 0.11 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.87 Pain Relevance 0.42
Also, NEP expression was down-regulated in cells derived from malignant tissues taken from radical prostatectomies compared to those cells derived from benign prostatic hyperplasia (BPH).
Negative_regulation (regulated) of Gene_expression (expression) of NEP associated with malignant neoplastic disease and benign prostatic hypertrophy
15) Confidence 0.11 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.09 Pain Relevance 0.36

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