INT110580

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.98
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
plasma 3
liver 1
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 3 99.82 Very High Very High Very High
Paracetamol 166 98.88 Very High Very High Very High
dexamethasone 1 98.24 Very High Very High Very High
fluoxetine 1 88.76 High High
Desipramine 1 87.72 High High
depression 1 82.12 Quite High
Potency 2 72.00 Quite High
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 18 97.08 Very High Very High Very High
Depression 1 82.12 Quite High
Attention Deficit Hyperactivity Disorder 1 79.20 Quite High
Injury 22 78.16 Quite High
Decapitation 4 77.44 Quite High
Overdose 12 49.32 Quite Low
Stress 18 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These antidepressants did not affect GR-mediated transcription by themselves, but significantly inhibited dexamethasone-induced transcription.
Neg (not) Regulation (affect) of Transcription (transcription) of GR-mediated associated with antidepressant and dexamethasone
1) Confidence 0.27 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12757900 Disease Relevance 0.16 Pain Relevance 0.36
By itself, APAP increased MDA formation and had a significant lowering influence on the levels of GSH and GSSG, the GSH/GSSH ratio, and the activities of GR, GST and GCS both in the plasma and liver.
Regulation (influence) of Transcription (activities) of GR in plasma associated with paracetamol
2) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.41 Pain Relevance 0.79
By itself, APAP increased MDA formation and had a significant lowering influence on the levels of GSH and GSSG, the GSH/GSSH ratio, and the activities of GR, GST and GCS both in the plasma and liver.
Regulation (influence) of in liver Transcription (activities) of GR in plasma associated with paracetamol
3) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.41 Pain Relevance 0.79

General Comments

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