INT110581

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
lymphocytes 2
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 6 99.98 Very High Very High Very High
fluoxetine 2 99.34 Very High Very High Very High
Desipramine 2 98.82 Very High Very High Very High
dexamethasone 2 96.36 Very High Very High Very High
depression 2 92.04 High High
Disease Link Frequency Relevance Heat
Depression 2 92.04 High High
Attention Deficit Hyperactivity Disorder 2 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that structurally different antidepressants induce translocation of GR and inhibit GR-mediated transcription.
Positive_regulation (induce) of Localization (translocation) of GR associated with antidepressant
1) Confidence 0.68 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12757900 Disease Relevance 0.15 Pain Relevance 0.34
Desipramine, clomiplamine, fluoxetine, milnacipran and clorgyline all induced rapid and sustained translocation of GR into the nucleus of human lymphocytes.
Positive_regulation (induced) of Localization (translocation) of GR in lymphocytes associated with desipramine and fluoxetine
2) Confidence 0.68 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12757900 Disease Relevance 0.18 Pain Relevance 0.36

General Comments

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