INT110582

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Context Info
Confidence 0.79
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.03
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
lens 2
nucleus 2
lymphocytes 1
skin 1
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 6 99.84 Very High Very High Very High
fluoxetine 2 98.78 Very High Very High Very High
cytokine 15 98.54 Very High Very High Very High
Desipramine 2 98.26 Very High Very High Very High
Biofeedback 3 97.20 Very High Very High Very High
dexamethasone 9 96.08 Very High Very High Very High
depression 9 90.92 High High
aspirin 32 88.36 High High
Inflammation 49 80.76 Quite High
corticosteroid 6 75.16 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 84 98.80 Very High Very High Very High
Shock 5 97.60 Very High Very High Very High
Stress 129 93.48 High High
Inflammatory Bowel Disease 5 91.68 High High
Depression 9 90.92 High High
Attention Deficit Hyperactivity Disorder 2 88.00 High High
Asthma 26 84.20 Quite High
Sepsis 33 81.08 Quite High
INFLAMMATION 59 80.76 Quite High
Stroke 54 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Desipramine, clomiplamine, fluoxetine, milnacipran and clorgyline all induced rapid and sustained translocation of GR into the nucleus of human lymphocytes.
Localization (translocation) of GR in lymphocytes associated with desipramine and fluoxetine
1) Confidence 0.79 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12757900 Disease Relevance 0.18 Pain Relevance 0.36
These results indicate that structurally different antidepressants induce translocation of GR and inhibit GR-mediated transcription.
Localization (translocation) of GR associated with antidepressant
2) Confidence 0.79 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12757900 Disease Relevance 0.15 Pain Relevance 0.34
Potential mechanisms for cytokine-induced reduction in GR function and affinity may include inhibition of GR translocation from cytoplasm to nucleus and reduction in GR-mediated gene transcription [68].
Localization (translocation) of GR in nucleus associated with cytokine
3) Confidence 0.45 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.65 Pain Relevance 0.18
Therefore, the presence of GR?
Localization (presence) of GR
4) Confidence 0.26 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0.03
Such changes remained in FENNS-4w with exception that the ratio of UA/Gr was normalized.
Localization (ratio) of Gr
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2831068 Disease Relevance 0.34 Pain Relevance 0
mRNA was 300-600 fold less represented than GR?
Localization (represented) of GR
6) Confidence 0.25 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.31 Pain Relevance 0
Because these investigators used two different antibodies that may not recognise GR?
Neg (not) Localization (recognise) of GR
7) Confidence 0.25 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.42 Pain Relevance 0.03
Cellular location of GR was analyzed semi-quantitatively (100× lens; Figure 3B1, B2).


Spec (analyzed) Localization (location) of GR in lens
8) Confidence 0.20 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2954925 Disease Relevance 0 Pain Relevance 0
Glutathione reductase (GR) did not decrease in the lens of the untreated diabetic rats 13 weeks after injection (Table 5) whereas CA seemed to have raised GR activity (p<0.05, when group I was compared with group VII.
Neg (not) Localization (decrease) of GR in lens associated with diabetes mellitus
9) Confidence 0.19 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2600521 Disease Relevance 0.63 Pain Relevance 0.07
Upon ligand binding the GR-GC complex is released from the chaperone complex to translocate to the cell nucleus (see Figure 3B3).
Localization (released) of GR in nucleus
10) Confidence 0.19 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2954925 Disease Relevance 0.96 Pain Relevance 0.08
Then they performed a serial subtraction task for 2 min, and rested again for 2 min while we monitored their palmer Galvanic skin response (GSR), finger skin temperature and finger plethysmogram amplitude using a biofeedback system (Multitrace Biofeedback, Thort Technology, USA).
Localization (response) of GSR in skin associated with biofeedback
11) Confidence 0.04 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1142199 Disease Relevance 0.39 Pain Relevance 0.10

General Comments

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