INT110599

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 49
Total Number 53
Disease Relevance 41.23
Pain Relevance 6.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bglap) cytoplasm (Bglap)
Anatomy Link Frequency
osteoblasts 3
stem cell 3
acinar cells 2
Capan-1 1
CII 1
Bglap (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 511 99.90 Very High Very High Very High
cytokine 126 99.50 Very High Very High Very High
corticosteroid 4 97.12 Very High Very High Very High
Arthritis 114 96.04 Very High Very High Very High
rheumatoid arthritis 75 72.24 Quite High
cINOD 1 69.12 Quite High
fibrosis 28 68.40 Quite High
Intracerebroventricular 8 65.92 Quite High
Inflammation 50 63.60 Quite High
imagery 41 60.84 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 868 100.00 Very High Very High Very High
Osteoporosis 196 100.00 Very High Very High Very High
Hypercalcemia 93 100.00 Very High Very High Very High
Reprotox - General 1 30 99.96 Very High Very High Very High
Pancreatitis 511 99.90 Very High Very High Very High
Pancreatic Cancer 812 99.84 Very High Very High Very High
Cancer 469 99.68 Very High Very High Very High
Disease 97 99.68 Very High Very High Very High
Immunization 15 99.42 Very High Very High Very High
Malignant Neoplastic Disease 84 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
was able to moderately but consistently reduce BGLAP mRNA and protein levels in the four cultured pancreatic cancer cell lines (figure 6A &6B).
Gene_expression (levels) of BGLAP associated with pancreatic cancer
1) Confidence 0.74 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.96 Pain Relevance 0.09
BGLAP expression was weak to absent in normal pancreatic ductal cells of 9/10 normal pancreatic tissues (figure 2A).
Neg (absent) Gene_expression (expression) of BGLAP
2) Confidence 0.74 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.11 Pain Relevance 0.43
However, since cytoplasmic expression of BGLAP was also observed in tubular complexes and cancer cells, it could be speculated that BGLAP is not efficiently released from these cells.
Gene_expression (expression) of BGLAP associated with cancer
3) Confidence 0.74 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.15 Pain Relevance 0.22
Since BGLAP was expressed in pancreatic cancer tissues and cells, various growth factors that might be involved in pancreatic carcinogenesis were examined for their effect on BGLAP expression.
Gene_expression (expressed) of BGLAP associated with pancreatic cancer
4) Confidence 0.74 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.21 Pain Relevance 0.14
Since BGLAP was expressed in pancreatic cancer tissues and cells, various growth factors that might be involved in pancreatic carcinogenesis were examined for their effect on BGLAP expression.
Gene_expression (expression) of BGLAP associated with pancreatic cancer
5) Confidence 0.74 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.05 Pain Relevance 0.12
This might indicate that BGLAP is expressed in the disease-specific tissue elements such as the tubular complexes, PanINs and cancer cells.
Gene_expression (expressed) of BGLAP associated with cancer and disease
6) Confidence 0.74 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.44 Pain Relevance 0.25
In a subsequent step, the expression of BGLAP was determined in Aspc-1, Capan-1, Panc-1 and T3M4 cultured pancreatic cancer cells.
Gene_expression (expression) of BGLAP in Capan-1 associated with pancreatic cancer
7) Confidence 0.74 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.35 Pain Relevance 0.16
In addition, BGLAP protein was detected in the cell culture supernatants of the same four cell lines by EIA, where the range of BGLAP expression was 3.4 to 4 ng/ml (figure 5B).
Gene_expression (expression) of BGLAP
8) Confidence 0.74 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.26 Pain Relevance 0.15
The other cytokines demonstrated no significant effects on BGLAP expression in the tested pancreatic cancer cells (data not shown).
Gene_expression (expression) of BGLAP associated with pancreatic cancer and cytokine
9) Confidence 0.74 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.70 Pain Relevance 0.09
BGLAP siRNA transfection was performed using RNAifect transfection reagent (Qiagen, Hilden, Germany) according to the manufacturer's instructions.
Gene_expression (transfection) of BGLAP
10) Confidence 0.57 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.16 Pain Relevance 0.03
In this study, we analyzed the expression and role of BGLAP in the normal human pancreas, chronic pancreatitis (CP), and pancreatic ductal adenocarcinoma (PDAC) using quantitative RT-PCR, immunohistochemistry, immunocytochemistry and enzyme immunoassays, as well as cell proliferation and invasion assays.
Spec (analyzed) Gene_expression (expression) of BGLAP in pancreas associated with adenocarcinoma and chronic pancreatitis
11) Confidence 0.57 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC2245975 Disease Relevance 0.70 Pain Relevance 0.32
Accordingly, defects in BGLAP expression lead to the development of chondrodysplasia punctata, coagulation defects, and coumarin embryopathy [9].
Gene_expression (expression) of BGLAP associated with coagulation disorder, fetal diseases and chondrodysplasia
12) Confidence 0.57 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.96 Pain Relevance 0
In conclusion, BGLAP is expressed in the tubular complexes and cancer cells of CP and PDAC tissues and has the potential to increase pancreatic cancer cell growth and invasion.


Gene_expression (expressed) of BGLAP associated with adenocarcinoma, cancer, pancreatic cancer and chronic pancreatitis
13) Confidence 0.57 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.74 Pain Relevance 0.21
The other growth factors and cytokines exhibited no effects on BGLAP expression in the tested pancreatic cancer cells.
Gene_expression (expression) of BGLAP associated with pancreatic cancer and cytokine
14) Confidence 0.57 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.24 Pain Relevance 0.09
Furthermore, BGLAP expression was found in the cancer cells in PDAC tissues as well as in 4 cultured pancreatic cancer cell lines.
Gene_expression (expression) of BGLAP associated with adenocarcinoma, cancer and pancreatic cancer
15) Confidence 0.57 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC2245975 Disease Relevance 1.22 Pain Relevance 0.34
TNFalpha reduced BGLAP mRNA and protein expression levels in pancreatic cancer cell lines.
Gene_expression (expression) of BGLAP associated with pancreatic cancer
16) Confidence 0.57 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC2245975 Disease Relevance 1.20 Pain Relevance 0.32
BGLAP was present in the cytoplasm and occasionally in the nuclei of pancreatic cancer cell lines as determined in the four cultured pancreatic cancer cell lines by immunocytochemistry (figure 5B).
Gene_expression (present) of BGLAP associated with pancreatic cancer
17) Confidence 0.57 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.26 Pain Relevance 0.15
BGLAP is an 11 kDa protein which is synthesized and secreted by normal maturing osteoblasts [2].
Gene_expression (synthesized) of BGLAP in osteoblasts
18) Confidence 0.57 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.43 Pain Relevance 0
reduced the expression of BGLAP in pancreatic cancer cell lines.
Gene_expression (expression) of BGLAP associated with pancreatic cancer
19) Confidence 0.57 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.35 Pain Relevance 0.15
Thus, serum BGLAP levels are reduced in patients with multiple myeloma with osteolytic bone lesions [11].
Gene_expression (levels) of BGLAP associated with multiple myeloma
20) Confidence 0.57 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.84 Pain Relevance 0.05

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