INT110607

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.59
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNK2)
Anatomy Link Frequency
ovary 4
plasma 2
KCNK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 97.48 Very High Very High Very High
depression 1 96.56 Very High Very High Very High
anesthesia 2 92.72 High High
Neuronal excitability 1 91.08 High High
Central nervous system 3 90.36 High High
potassium channel 1 87.92 High High
Neurotransmitter 1 82.52 Quite High
ischemia 1 70.00 Quite High
Regional anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Epilepsy 1 98.48 Very High Very High Very High
Pain 2 97.48 Very High Very High Very High
Depression 1 96.56 Very High Very High Very High
Acidosis 2 83.44 Quite High
Cv Unclassified Under Development 1 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our aim was to characterize with the patch-clamp technique the properties of human TREK-1 channels and the effects of bupivacaine on these channels expressed in Chinese hamster ovary (CHO) cells.
Regulation (effects) of Gene_expression (expressed) of TREK-1 in CHO
1) Confidence 0.45 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12760993 Disease Relevance 0.15 Pain Relevance 0
Their effects on TREK-1 surface expression and activation are cumulative.
Regulation (effects) of Gene_expression (expression) of TREK-1
2) Confidence 0.34 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716213 Disease Relevance 0.14 Pain Relevance 0.22
Little, however, is known about the regulation of TREK1 expression on the transcriptional and translational level or about its trafficking to the plasma membrane.
Regulation (regulation) of Gene_expression (expression) of TREK1 in plasma
3) Confidence 0.27 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20605797 Disease Relevance 0.29 Pain Relevance 0.19
We have investigated the ability of 2,2,2-trichloroethanol (an active metabolite of the general anesthetic chloral hydrate (CH)) to modulate the activity of hTREK-1 and hTRAAK channels expressed heterologously in Chinese hamster ovary cells by using whole-cell patch-clamp recording.
Regulation (modulate) of Gene_expression (expressed) of hTREK-1 in ovary
4) Confidence 0.15 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14996553 Disease Relevance 0 Pain Relevance 0.23

General Comments

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