INT110608

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 0.91
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNK2)
Anatomy Link Frequency
neuronal 1
pore 1
bladder 1
external 1
KCNK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 11 99.84 Very High Very High Very High
lidocaine 27 99.80 Very High Very High Very High
antidepressant 1 98.16 Very High Very High Very High
fluoxetine 1 97.56 Very High Very High Very High
depression 2 96.48 Very High Very High Very High
Pain 3 95.40 Very High Very High Very High
anesthesia 1 95.16 Very High Very High Very High
Regional anesthesia 4 94.80 High High
potassium channel 60 94.20 High High
halothane 1 89.84 High High
Disease Link Frequency Relevance Heat
Acidosis 8 99.92 Very High Very High Very High
Depression 2 96.48 Very High Very High Very High
Pain 1 95.40 Very High Very High Very High
Cv General 4 Under Development 4 65.48 Quite High
Cv Unclassified Under Development 2 50.40 Quite High
Shock 1 43.36 Quite Low
Pre-term Labor 10 14.36 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 5.00 Very Low Very Low Very Low
Premature Birth 6 5.00 Very Low Very Low Very Low
Endometriosis (extended) 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of TREK-1 channels and consecutive depolarization of the cell membrane by bupivacaine may contribute to blockade of neuronal signal conduction during regional anesthesia.
Negative_regulation (Inhibition) of TREK-1 in neuronal associated with regional anesthesia
1) Confidence 0.59 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12760993 Disease Relevance 0.15 Pain Relevance 0.09
Inhibition of TREK-1 channels by bupivacaine was reversible, concentration-dependent, voltage-independent, and increased with intracellular acidosis.
Negative_regulation (Inhibition) of TREK-1 associated with acidosis
2) Confidence 0.59 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12760993 Disease Relevance 0.20 Pain Relevance 0
Inhibition of human TREK-1 channels by bupivacaine.
Negative_regulation (Inhibition) of TREK-1
3) Confidence 0.59 Published 2003 Journal Anesth. Analg. Section Title Doc Link 12760993 Disease Relevance 0.14 Pain Relevance 0
Lidocaine, at clinical concentrations, produced reversible, concentration-dependent inhibition of hTREK1 current, with IC(50) value of 180 muM, by reducing the single-channel open probability and stabilizing the closed state.
Negative_regulation (inhibition) of hTREK1 associated with lidocaine
4) Confidence 0.51 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19622790 Disease Relevance 0 Pain Relevance 0.65
Furthermore, the phosphorylation state of Ser348 was found to have a regulatory role in lidocaine-mediated inhibition of hTREK1.
Negative_regulation (inhibition) of hTREK1 associated with lidocaine
5) Confidence 0.51 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19622790 Disease Relevance 0 Pain Relevance 0.84
Inhibition of human two-pore domain K+ channel TREK1 by local anesthetic lidocaine: negative cooperativity and half-of-sites saturation kinetics.
Negative_regulation (Inhibition) of TREK1 in pore associated with lidocaine and local anesthetic
6) Confidence 0.43 Published 2009 Journal Mol. Pharmacol. Section Title Doc Link 19622790 Disease Relevance 0 Pain Relevance 0.66
Bupivacaine inhibited TREK-1 channels and depolarized the membrane potential of cells expressing TREK-1 channels in a concentration-dependent and reversible manner.
Negative_regulation (inhibited) of TREK-1
7) Confidence 0.43 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12760993 Disease Relevance 0.12 Pain Relevance 0.09
Our findings are consistent with previous studies showing the inhibition of TREK-1 channels by methionine containing compounds or fluphenazine [17], [33], [34].
Negative_regulation (inhibition) of TREK
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.12 Pain Relevance 0.06
It has been shown in bladder smooth muscle that methionine and its derivatives inhibit TREK channels, thereby increasing bladder excitability [17], [33].
Negative_regulation (inhibit) of TREK in bladder
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.05
Here, we report that external acidification, within the physiological range, strongly inhibits the human K2P2.1 channel by inducing "C-type" closure.
Negative_regulation (inhibits) of K2P2.1 in external
10) Confidence 0.42 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18474599 Disease Relevance 0.19 Pain Relevance 0.32
TREK channels are also inhibited by chlorpromazine, local anesthetics and the antidepressant fluoxetine.
Negative_regulation (inhibited) of TREK associated with antidepressant, fluoxetine and local anesthetic
11) Confidence 0.30 Published 2007 Journal Curr Opin Investig Drugs Section Abstract Doc Link 17659475 Disease Relevance 0 Pain Relevance 0.49

General Comments

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