INT110609

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.25
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNK2)
KCNK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 27 100.00 Very High Very High Very High
Regional anesthesia 2 99.20 Very High Very High Very High
local anesthetic 9 75.00 Quite High
Disease Link Frequency Relevance Heat
Acidosis 4 68.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In view of their physiological significance, interaction of bupivacaine with TREK-1 channels may be clinically important.
TREK-1 Binding (interaction) of
1) Confidence 0.48 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12760993 Disease Relevance 0.12 Pain Relevance 0
IMPLICATIONS: The interaction of bupivacaine with human TREK-1 channels was studied with the patch-clamp technique.
TREK-1 Binding (interaction) of
2) Confidence 0.42 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12760993 Disease Relevance 0.13 Pain Relevance 0.10
Studies with the heterodimer of wild-type (wt)-hTREK1 and Delta119 C-terminal deletion mutant (hTREK1(wt)-Delta119) revealed that single CTD of hTREK1 was capable of mediating partial inhibition by lidocaine, but complete inhibition necessitates the cooperative interaction between both the CTDs upon binding of lidocaine.
hTREK1 Binding (binding) of associated with lidocaine
3) Confidence 0.32 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19622790 Disease Relevance 0 Pain Relevance 0.93
Studies with the heterodimer of wild-type (wt)-hTREK1 and Delta119 C-terminal deletion mutant (hTREK1(wt)-Delta119) revealed that single CTD of hTREK1 was capable of mediating partial inhibition by lidocaine, but complete inhibition necessitates the cooperative interaction between both the CTDs upon binding of lidocaine.
hTREK1 Binding (binding) of associated with lidocaine
4) Confidence 0.32 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19622790 Disease Relevance 0 Pain Relevance 0.95
It is interesting that we observed strong intersubunit negative cooperativity (Hill coefficient = 0.49) and half-of-sites saturation binding stoichiometry (half-reaction order) for the binding of lidocaine to hTREK1.
hTREK1 Binding (binding) of associated with lidocaine
5) Confidence 0.31 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19622790 Disease Relevance 0 Pain Relevance 0.90

General Comments

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