INT11062

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Context Info
Confidence 0.63
First Reported 1982
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 24
Total Number 28
Disease Relevance 14.37
Pain Relevance 5.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
neutrophil 3
muscle 1
substantia nigra 1
granulocytes 1
leukocytes 1
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 4 99.98 Very High Very High Very High
dexamethasone 1 99.88 Very High Very High Very High
narcan 2 99.76 Very High Very High Very High
substance P 15 99.44 Very High Very High Very High
addiction 2 99.08 Very High Very High Very High
Opioid 1 98.68 Very High Very High Very High
Calcitonin gene-related peptide 4 98.66 Very High Very High Very High
Inflammatory response 7 98.36 Very High Very High Very High
headache 6 98.24 Very High Very High Very High
Enkephalin 26 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 313 100.00 Very High Very High Very High
Diabetes Mellitus 35 99.90 Very High Very High Very High
Prostate Cancer 54 99.66 Very High Very High Very High
Endodermal Sinus Tumor 2 99.32 Very High Very High Very High
Renal Cancer 78 99.08 Very High Very High Very High
Disease 41 99.08 Very High Very High Very High
Hyperglycemia 11 99.08 Very High Very High Very High
Hyperlipidemia 10 99.08 Very High Very High Very High
Opiate Addiction 2 99.08 Very High Very High Very High
Lymphatic System Cancer 6 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone also increased NEP, suggesting that the effect is due to glucocorticoid receptor effects.
Positive_regulation (increased) of NEP associated with dexamethasone
1) Confidence 0.63 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1847594 Disease Relevance 0 Pain Relevance 0.13
Exposure of intact human granulocytes to morphine increases NEP by a naloxone-sensitive mechanism.
Positive_regulation (increases) of NEP in granulocytes associated with narcan and morphine
2) Confidence 0.60 Published 1994 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7519178 Disease Relevance 0.31 Pain Relevance 0.68
High glucose or fatty acid concentration upregulated NEP activity.
Positive_regulation (upregulated) of NEP
3) Confidence 0.60 Published 2003 Journal Shock Section Abstract Doc Link 12785004 Disease Relevance 0.83 Pain Relevance 0.15
The modulator effect of vitamin E and C on NEP membrane enzyme activity after exposure to fatty acid stimulation suggests that lipid oxidation may activate NEP.
Spec (may) Positive_regulation (activate) of NEP
4) Confidence 0.60 Published 2003 Journal Shock Section Abstract Doc Link 12785004 Disease Relevance 0.36 Pain Relevance 0.05
We postulate that prostate tumors expressing high levels of CD10 correlate with a poor disease outcome.
Positive_regulation (levels) of CD10 associated with prostate cancer and disease
5) Confidence 0.50 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.74 Pain Relevance 0
These three CD10/NEP substrates induce the migration and aggregation of neutrophils, suggesting that each of the peptides can function as a mediator of neutrophil inflammatory responses.
Positive_regulation (induce) of CD10 in neutrophil associated with inflammatory response
6) Confidence 0.49 Published 1991 Journal Blood Section Abstract Doc Link 1717072 Disease Relevance 0.40 Pain Relevance 0.27
In such cases, demonstration of CD 10, Hep Par 1, membraneous patterns of p-CEA and CK7 would be invaluable for characterizing the tumor as hepatoid carcinoma.
Positive_regulation (demonstration) of CD 10 associated with cancer and carcinoma
7) Confidence 0.49 Published 2004 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 15597858 Disease Relevance 1.37 Pain Relevance 0.10
In these conditions "enkephalinase" activity (EKA) generally results increased.
Positive_regulation (increased) of enkephalinase
8) Confidence 0.47 Published 1986 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3544724 Disease Relevance 0.20 Pain Relevance 0.49
Like CD10, a smaller percentage of cancer glands were positive for CD13.
Positive_regulation (positive) of CD10 in glands associated with cancer
9) Confidence 0.46 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.59 Pain Relevance 0
Enkephalinase activity is distributed in a highly heterogeneous fashion among regions of human brain, the highest levels being found in globus pallidus and pars reticulata of the substantia nigra.
Positive_regulation (distributed) of Enkephalinase in substantia nigra associated with substantia nigra
10) Confidence 0.46 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6811698 Disease Relevance 0 Pain Relevance 0.51
The distribution of NEP detected immunocytochemically using anti-NEP monoclonal antibodies was also found to be parallel with the distribution of NEP activity among peripheral blood leukocytes.
Positive_regulation (using) of anti-NEP in leukocytes
11) Confidence 0.44 Published 1991 Journal J. Leukoc. Biol. Section Abstract Doc Link 1991995 Disease Relevance 0.08 Pain Relevance 0.11
Additional experiments demonstrated that the activity of neutral endopeptidase (NEP) in the tracheal epithelium was not significantly different in guinea pigs injected with LPS from that in the saline-treated control animals, and that the pretreatment with the NEP inhibitor phosphoramidon did not increase the LPS-induced influx of neutrophils into the bronchoalveolar lavage.
Neg (not) Positive_regulation (increase) of NEP in neutrophils
12) Confidence 0.44 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 8111569 Disease Relevance 0.11 Pain Relevance 0.63
RESULTS: MENK inhibited the growth, invasion and survival of CRC cells following thiorphan-induced CD10 inactivation.
Positive_regulation (induced) of CD10
13) Confidence 0.42 Published 2010 Journal Gut Section Body Doc Link 19828468 Disease Relevance 0.15 Pain Relevance 0
The increase in NEP activity in methacholine-induced secretions was prevented by atropine (0.13 +/- 0.06 pmol/min/ml).
Positive_regulation (increase) of NEP
14) Confidence 0.41 Published 1993 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8217197 Disease Relevance 0 Pain Relevance 0.12
Increase of neutral endopeptidase-24.11 with cellular density and enzyme modulation with an inhibitor on human Reh6 cell line.
Positive_regulation (Increase) of neutral endopeptidase
15) Confidence 0.41 Published 1992 Journal Biochem. Pharmacol. Section Title Doc Link 1533518 Disease Relevance 0.18 Pain Relevance 0.11
NEP activity per cell was found to increase during the cell growth of Reh6 and CEM cells, a cell-cell contact mechanism being suggested by experiments using Transwell cell chambers.
Positive_regulation (increase) of NEP
16) Confidence 0.41 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1533518 Disease Relevance 0.18 Pain Relevance 0.09
We hypothesized that hyperlipidemia and hyperglycemia associated with type 2 diabetes mellitus may induce excessive NEP activity and thereby diminish normal response to injury.
Spec (may) Positive_regulation (induce) of NEP associated with hyperglycemia, diabetes mellitus, injury and hyperlipidemia
17) Confidence 0.40 Published 2003 Journal Shock Section Abstract Doc Link 12785004 Disease Relevance 0.76 Pain Relevance 0.18
We have previously demonstrated increased NEP localization and enzyme activity in diabetic wounds and skin compared with normal controls.
Positive_regulation (increased) of NEP in skin associated with diabetes mellitus and injury
18) Confidence 0.40 Published 2003 Journal Shock Section Abstract Doc Link 12785004 Disease Relevance 0.74 Pain Relevance 0.19
Thus, hyperglycemia and hyperlipidemia associated with type 2 diabetes mellitus may increase endothelial cell NEP activity and thereby decrease early pro-inflammatory responses.
Spec (may) Positive_regulation (increase) of NEP in endothelial cell associated with hyperglycemia, inflammatory response, diabetes mellitus and hyperlipidemia
19) Confidence 0.40 Published 2003 Journal Shock Section Abstract Doc Link 12785004 Disease Relevance 0.72 Pain Relevance 0.05
Univariate analysis of the data could have led one to postulate a causal link between the NEP and HIV seroconversion as cumulative incidence was significantly elevated in frequent attenders at the NEP.
Positive_regulation (elevated) of NEP associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.33 Published 2006 Journal Harm Reduct J Section Body Doc Link PMC1569828 Disease Relevance 0.57 Pain Relevance 0.04

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