INT11063

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Context Info
Confidence 0.53
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 6.92
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CES1)
Anatomy Link Frequency
liver 1
CES1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
Morphine 2 99.40 Very High Very High Very High
fluoxetine 1 99.32 Very High Very High Very High
Nortriptyline 2 96.36 Very High Very High Very High
Paracetamol 2 96.32 Very High Very High Very High
Desipramine 2 94.36 High High
Enkephalin 1 91.04 High High
Inflammation 49 83.92 Quite High
Inflammatory response 10 68.12 Quite High
Potency 1 54.32 Quite High
Disease Link Frequency Relevance Heat
Depression 3 100.00 Very High Very High Very High
Coronary Artery Disease 70 99.84 Very High Very High Very High
Obesity 60 99.30 Very High Very High Very High
Death 33 99.30 Very High Very High Very High
Chronic Disease 52 99.18 Very High Very High Very High
Diabetes Mellitus 106 98.92 Very High Very High Very High
Epstein-barr Virus 85 98.60 Very High Very High Very High
Hodgkin's Disease 219 98.52 Very High Very High Very High
Anaemia 6 98.06 Very High Very High Very High
Leukemia 3 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depression of PCE activity can prolong the half-life of coadministered agents with metabolism mediated by PCE.
Negative_regulation (Depression) of PCE associated with depression
1) Confidence 0.53 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 16040293 Disease Relevance 0.10 Pain Relevance 0.32
Our findings that non-CAD chronic disease death rates increase with neighbourhood SES deprivation in CAD patients suggests neighbourhood conditions may independently instigate longer term health effects which persist in the context of a medical system designed to provide care regardless of individual-level SES.
Negative_regulation (deprivation) of SES associated with coronary artery disease, death and chronic disease
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606022 Disease Relevance 0.54 Pain Relevance 0
Morphine, quinidine, and thioridazine depressed PCE activity by more than 5% while no or negligible effect was noted following incubation with acetaminophen, chlordiazepoxide, chlorpromazine, desipramine, doxepin, imipramine, methamphetamine, nortriptyline, phenobarbital, phenytoin, procainamide, salicylic acid, theophylline, and valproic acid.
Negative_regulation (depressed) of PCE associated with nortriptyline, desipramine, paracetamol and morphine
3) Confidence 0.46 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 16040293 Disease Relevance 0.08 Pain Relevance 0.33
Amino acid substitutions were observed for other key regions reported for human CES1, including the Z-site Gly354 (involved in cholesterol binding) [3], which was retained for human and opossum CES2Like gene products and human CES7, but replaced in opossum CES1, human CES3 and in opossum and human CES6 sequences; the human CES1 'side door' sequence at 423Val-Met-Phe425 (proposed to regulate fatty acid residue release following hydrolysis of fatty acyl ester linkages [3]) and the 'aromatic-releasing' residue (the 'gate') at 551Phe have each undergone conservative substitutions for the opossum and human CES sequences analyzed.
Negative_regulation (replaced) of CES1
4) Confidence 0.42 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The RT-PCR studies reported earlier for opossum CES1, CES2, CES2.2 and CES2.3 genes confirm the existence, expression and sequences for CES coding regions for these opossum genes.
Negative_regulation (opossum) of CES1
5) Confidence 0.42 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Predicted Opossum CES1 Amino Acid Sequence
Negative_regulation (Predicted) of CES1
6) Confidence 0.36 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
It is difficult to imagine that exposures are distributed in this fashion as well; i.e. that for each increment in neighborhood SES there is a corresponding reduction in contact with toxicants.
Negative_regulation (reduction) of SES
7) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606022 Disease Relevance 0.63 Pain Relevance 0.03
In developed countries obesity rates in women rise linearly with decreasing SES; the pattern for men is less straightforward and there are less steep, and in some places no or non linear, SES gradients in men [18-21].
Negative_regulation (decreasing) of SES associated with obesity
8) Confidence 0.21 Published 2005 Journal Int J Behav Nutr Phys Act Section Body Doc Link PMC1277840 Disease Relevance 0.48 Pain Relevance 0
While it is notably difficult to comprehensively define SES, several studies commonly utilize proxies for SES, such as economically disadvantaged, limited education and social support.
Negative_regulation (define) of SES
9) Confidence 0.07 Published 2007 Journal The California Journal of Emergency Medicine Section Body Doc Link PMC2859736 Disease Relevance 0.76 Pain Relevance 0
Iron deficiency lowers serum retinol, and vitamin A accumulates in the liver as retinyl esters, probably due to impaired activity of hepatic acid retinyl ester hydrolase, an iron-dependent enzyme (31).
Negative_regulation (impaired) of hepatic acid retinyl ester hydrolase in liver associated with anaemia
10) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.58 Pain Relevance 0
As noted above, the shift towards Western lifestyle in Singapore was accompanied by a shift in HL incidence, and in the UK, patients who had the highest rates of material deprivation (lowest SES) had a three-time higher risk for EBV-positive HL.
Negative_regulation (deprivation) of SES associated with epstein-barr virus and hodgkin's disease
11) Confidence 0.02 Published 2011 Journal Advances in Hematology Section Body Doc Link PMC2994062 Disease Relevance 1.33 Pain Relevance 0
Increase of neutral endopeptidase-24.11 with cellular density and enzyme modulation with an inhibitor on human Reh6 cell line.
Negative_regulation (inhibitor) of Reh6
12) Confidence 0.02 Published 1992 Journal Biochem. Pharmacol. Section Title Doc Link 1533518 Disease Relevance 0.19 Pain Relevance 0.12
As drug-eluting stents have recently been widely applied to majority of diabetic patients during percutaneous coronary intervention in routine clinical practice, determination of the inhibitory effect of SES on neointimal growth in a diabetic animal model may be more relevant to the understanding of mechanism for an increased restenosis rate seen in the clinical diabetic cohort, although neointimal proliferation was supposed to be same as in bare-metal stent studies[19].
Negative_regulation (effect) of SES associated with diabetes mellitus and restenosis
13) Confidence 0.02 Published 2007 Journal Cardiovasc Diabetol Section Body Doc Link PMC1892541 Disease Relevance 1.38 Pain Relevance 0.03
These children were compared with groups of control children with average SES, children raised in families with a heroin-dependent father, or children born in families with low SES and high environmental deprivation.
Negative_regulation (deprivation) of SES
14) Confidence 0.01 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247191 Disease Relevance 0.20 Pain Relevance 0
However, the emodin content in PCE is reduced during processing to achieve a final content of ?
Negative_regulation (reduced) of PCE
15) Confidence 0.01 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2267461 Disease Relevance 0.65 Pain Relevance 0.18
Aripiprazole, perphenazine, thioridazine, and fluoxetine were determined to be the potent hCES1 inhibitors.
Negative_regulation (inhibitors) of hCES1 associated with fluoxetine
16) Confidence 0.00 Published 2010 Journal Toxicology Section Abstract Doc Link 20097249 Disease Relevance 0 Pain Relevance 0.10

General Comments

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