INT110633

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 4.34
Pain Relevance 9.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cardiac myocytes 1
neurons 1
node 1
Peripheral nerve 1
skeletal muscle 1
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nav1.2 267 100.00 Very High Very High Very High
nav1.8 240 100.00 Very High Very High Very High
Nav1.6 88 100.00 Very High Very High Very High
Nav1.9 12 100.00 Very High Very High Very High
Nav1.7 6 100.00 Very High Very High Very High
Kinase C 76 99.84 Very High Very High Very High
sodium channel 282 98.84 Very High Very High Very High
substance P 132 98.24 Very High Very High Very High
Cancer pain 33 97.92 Very High Very High Very High
dorsal root ganglion 221 97.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nerve Compression Syndromes 93 99.72 Very High Very High Very High
Sudden Death 6 97.96 Very High Very High Very High
Bone Cancer 10 97.72 Very High Very High Very High
Adhesions 40 97.44 Very High Very High Very High
Injury 329 97.28 Very High Very High Very High
Arrhythmias 2 Under Development 2 97.28 Very High Very High Very High
Ganglion Cysts 225 97.10 Very High Very High Very High
Heart Arrhythmia 10 93.92 High High
Cancer 41 93.44 High High
Pain 96 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracellular Nav1.8 domains interact widely with many proteins and immunoprecipitation assays have confirmed that some of these proteins may regulate Nav1.8 in vivo [32].
Nav1 Binding (interact) of associated with nav1.8
1) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 0.83 Pain Relevance 1.17
In contrast, the typical association of intense Nav1.6 at the node bordered on both sides by bright caspr staining in the paranodal area was altered in lesioned IONs (compare Fig. 1A to 1B and Fig. 2A to 2B).
Nav1.6 Binding (association) of in node associated with nav1.6
2) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.69
In agreement with our previous finding that the modulation of TRPV1 by NK-1 receptor was mediated by activation of PLC and downstream PKC pathway [9], the present results also proved the involvement of PKC in the interaction between NK-1 and Nav1.8.
Nav1.8 Binding (interaction) of associated with kinase c and nav1.8
3) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.21 Pain Relevance 1.46
M) still fully enhanced Nav1.8 currents in 9 of 24 DRG neurons (Figure 3C and 3D, control = 99.2 ± 0.5%, Sar-SP = 115.6 ± 2.1%, p < 0.001), suggesting that the PKA pathway did not participate in the interaction of NK-1 and Nav1.8.
Nav1.8 Binding (interaction) of in neurons associated with dorsal root ganglion, nav1.8 and substance p
4) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.17 Pain Relevance 1.60
M) than Nav1.8 or Nav1.9 [36]; thus upregulation of Nav1.5 could potentially account for the observed increases in TTX-resistance, including the blockade of A and C-fiber CAP conduction by 1 ?
Nav1 Binding (account) of associated with c fibre, nav1.8 and nav1.9
5) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.82 Pain Relevance 0.78
The current study demonstrates that desmoplakin and ankyrin-G are specifically recruited to PKP-containing adhesion plaques in remodeling cardiac myocytes and that localization of ankyrin-G to new intercalated disks significantly precedes the recruitment of Nav1.5, the alpha subunit of the VGSC.
Nav1 Binding (recruitment) of in cardiac myocytes associated with sodium channel and adhesions
6) Confidence 0.28 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.68 Pain Relevance 0.05
Recent studies have further demonstrated an interaction between PKP2 and Nav1.5, suggesting functional integration of the VGSC with other membrane proteins such as ankyrin and with desmosomal adhesive complexes [15].
Nav1 Binding (interaction) of associated with sodium channel
7) Confidence 0.28 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.29 Pain Relevance 0.13
Peripheral nerve NaV1.8 immunoreactivity after SNE
NaV1 Binding (immunoreactivity) of in Peripheral nerve associated with nerve compression syndromes
8) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.62 Pain Relevance 0.36
Ready-made Taqman expression assay sets (Applied Biosystems, Foster City, CA) were used for PCR amplification of various sodium channel cDNAs; the expression assay IDs were: NaV1.3, Rn00565438_m1; NaV1.5, Rn00565502_m1; NaV.16, Rn00570506_m1; NaV1.7, Rn00581647_m1; NaV1.8, Rn_00568393; NaV1.9, Rn00570487_m1.

3'Rapid amplification of cDNA ends (3'RACE)

NaV1 Binding (amplification) of associated with sodium channel
9) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.22 Pain Relevance 0.16
In our qPCR experiments we observed that the Nav1.9 isoform was very low abundance under our culture conditions, though it had levels similar to Nav 1.8 in cDNA derived from whole DRG.
Nav1 Binding (abundance) of associated with nav1.9
10) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.31
Both the genes coding for the a subunit Nav1.7 (Scn9a) and the ?
Nav1 Binding (coding) of associated with nav1.7
11) Confidence 0.24 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.19 Pain Relevance 0.29
Several genes of the Na+ subunits also undergo regulation, where the genes coding for Na+ a subunits Nav1.8 and Nav1.5 together with the ?
Nav1 Binding (coding) of associated with nav1.8
12) Confidence 0.24 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.15 Pain Relevance 0.27
Several genes of the Na+ subunits also undergo regulation, where the genes coding for Na+ a subunits Nav1.8 and Nav1.5 together with the ?
Nav1 Binding (coding) of associated with nav1.8
13) Confidence 0.24 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.15 Pain Relevance 0.27
In the present study, we analyzed the role of residue L1280 in D3-S6 of the rat skeletal muscle Nav1.4 channel in interactions with the enantiomers of bupivacaine.
Nav1 Binding (interactions) of in skeletal muscle
14) Confidence 0.23 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12761351 Disease Relevance 0 Pain Relevance 0.18
Precisely, the possibility of a dynamic modulation of ankyrin–Nav interaction by synaptic activity is a fascinating question that should be addressed in future studies.


Nav Binding (interaction) of
15) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.23
We first determined whether the ankyrin-binding motif of Nav1.2 is phosphorylated by CK2 by conducting in vitro phosphorylation assays with GST proteins fused either to the linker II-III of Nav1.2 (Nav1.2 II-III) or truncated mutants (Fig. 3 A).
Nav1 Binding (linker) of associated with nav1.2
16) Confidence 0.17 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 1.00
We showed that phosphorylation of these residues by protein kinase CK2 (CK2) regulates Nav channel interaction with ankyrins.
Nav Binding (interaction) of
17) Confidence 0.14 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.42

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