INT11064

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 14.63
Pain Relevance 4.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NPR1)
Anatomy Link Frequency
plasma 5
smooth muscle 3
spinal cord 2
platelet 2
smooth muscle cell 1
NPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
potassium channel 5 99.80 Very High Very High Very High
Spinal cord 10 99.36 Very High Very High Very High
adenocard 4 98.84 Very High Very High Very High
Thermal hyperalgesia 4 97.04 Very High Very High Very High
Angina 16 96.68 Very High Very High Very High
nMDA receptor 4 96.12 Very High Very High Very High
Clonidine 6 95.76 Very High Very High Very High
Lasting pain 4 95.72 Very High Very High Very High
anesthesia 3 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 47 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 93 99.78 Very High Very High Very High
Adult Respiratory Distress Syndrome 20 98.46 Very High Very High Very High
Diuresis 11 98.44 Very High Very High Very High
Leukemia 1 97.80 Very High Very High Very High
Sickle Cell Anemia 35 97.12 Very High Very High Very High
Hyperalgesia 5 97.04 Very High Very High Very High
Cv General 3 Under Development 110 96.68 Very High Very High Very High
Coronary Heart Disease 8 96.64 Very High Very High Very High
Toxicity 10 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent findings suggest that the induction of HbF by HU involves the activation of soluble guanylate cyclase by NO, and reduces the rates of vaso-occlusive crisis in patients with SCD and recent data suggest that HU treatment can generate nitric oxide (NO).
Positive_regulation (activation) of guanylate cyclase associated with sickle cell anemia
1) Confidence 0.49 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885637 Disease Relevance 1.02 Pain Relevance 0.08
GTN is thought to cause vasodilatation mainly by activation of soluble
guanylate cyclase (sGC), which is stimulated by the binding of NO to a
regulatory heme group. 
Positive_regulation (activation) of guanylate cyclase associated with increased venous pressure under development
2) Confidence 0.49 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.20 Pain Relevance 0.14
First, it increases potassium ion conductance by opening adenosine triphosphate (ATP)-sensitive potassium channels, in turn activating the enzyme guanylate cyclase.
Positive_regulation (activating) of guanylate cyclase associated with adenocard and potassium channel
3) Confidence 0.45 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941787 Disease Relevance 0.58 Pain Relevance 0.34
It can also inhibit the adhesion, aggregation, and recruitment of platelets; inhibit vascular smooth muscle cell migration and growth; regulate some vessel–platelet interactions; and limit the oxidation of atherogenic low-density lipoproteins.1 These actions are all mediated by the activation of soluble guanylate cyclase and the consequent increase in the concentration of cyclic GMP in target cells.3
Positive_regulation (activation) of guanylate cyclase in platelet associated with adhesions
4) Confidence 0.45 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2850180 Disease Relevance 0.39 Pain Relevance 0
Among the multiple activities of NO, the homeostatic control of the vascular endothelium is directly connected with the activation of soluble guanylate cyclase and the production of cyclic 3?
Positive_regulation (activation) of guanylate cyclase in vascular endothelium
5) Confidence 0.45 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253762 Disease Relevance 0.41 Pain Relevance 0
These indicate the existence of the natriuretic peptide receptor-B (NPR-B) mediating the relaxation.
Positive_regulation (mediating) of NPR-B associated with natriuresis
6) Confidence 0.40 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15927695 Disease Relevance 0.65 Pain Relevance 0.21
The mechanism responsible for the increases in serum atrial natriuretic peptide and the postoperative natriuresis and diuresis after cardiopulmonary bypass remain unknown.
Positive_regulation (increases) of atrial natriuretic peptide associated with diuresis and natriuresis
7) Confidence 0.37 Published 1992 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 1534591 Disease Relevance 1.18 Pain Relevance 0.07
Serum levels of atrial natriuretic peptide were found to be significantly elevated immediately after discontinuation of cardiopulmonary bypass.
Positive_regulation (elevated) of atrial natriuretic peptide associated with natriuresis
8) Confidence 0.37 Published 1992 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 1534591 Disease Relevance 0.90 Pain Relevance 0.10
The vasodilator effects of nitroglycerin (NTG) are mediated via activation of guanylate cyclase; this process is believed to require the availability of free sulfhydryl groups.
Positive_regulation (activation) of guanylate cyclase
9) Confidence 0.35 Published 1988 Journal Circulation Section Abstract Doc Link 3127076 Disease Relevance 0.26 Pain Relevance 0.26
It was been shown that physical exercise increases plasma atrial natriuretic peptide (ANP) level.
Positive_regulation (increases) of atrial natriuretic peptide in plasma associated with natriuresis
10) Confidence 0.35 Published 1989 Journal Pathol. Biol. Section Abstract Doc Link 2561015 Disease Relevance 0.17 Pain Relevance 0.39
Dihydralazine increases plasma and urinary cGMP, supposedly by direct activation of the soluble guanylate cyclase.
Positive_regulation (activation) of guanylate cyclase in plasma
11) Confidence 0.34 Published 1989 Journal J. Appl. Physiol. Section Abstract Doc Link 2551880 Disease Relevance 0.14 Pain Relevance 0.48
Plasma atrial natriuretic peptide levels remained elevated, but rises in plasma aldosterone and renin activity were transient.
Positive_regulation (elevated) of atrial natriuretic peptide in plasma associated with natriuresis
12) Confidence 0.33 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15148056 Disease Relevance 0.92 Pain Relevance 0.11
Plasma atrial natriuretic peptide (ANP) was low before WL, but increased normally in response to WL.
Positive_regulation (increased) of atrial natriuretic peptide in Plasma associated with natriuresis
13) Confidence 0.23 Published 1992 Journal Endocrinol. Jpn. Section Abstract Doc Link 1535041 Disease Relevance 0.92 Pain Relevance 0.07
An acute water load failed to suppress ADH release in the supine posture but slightly increased plasma atrial natriuretic peptide (ANP).
Neg (failed) Positive_regulation (increased) of atrial natriuretic peptide in plasma associated with natriuresis
14) Confidence 0.21 Published 1991 Journal Endocrinol. Jpn. Section Abstract Doc Link 1794339 Disease Relevance 1.18 Pain Relevance 0.08
Normally, endothelium-derived NO stimulates intracellular soluble guanylate cyclase resulting in increased levels of cGMP, which then acts to mediate smooth muscle relaxation (Figure 1).
Neg (NO) Positive_regulation (stimulates) of guanylate cyclase in smooth muscle
15) Confidence 0.13 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 0.69 Pain Relevance 0.19
This enzyme is involved in the inactivation of regulatory peptides such as enkephalins and atrial natriuretic peptide and its expression on the cell surface is therefore essential.
Positive_regulation (inactivation) of atrial natriuretic peptide associated with natriuresis and enkephalin
16) Confidence 0.11 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1533518 Disease Relevance 0.20 Pain Relevance 0.10
NO induces smooth muscle cell relaxation by activating soluble guanylate cyclase and by increasing the intracellular concentration of cGMP.
Positive_regulation (activating) of guanylate cyclase in smooth muscle cell
17) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.70 Pain Relevance 0.20
The promising effects of NO inhalation in ARDS [9, 10] also supported this hypothesis, because both NO and ANP act through activation of guanylate cyclase.
Positive_regulation (activation) of guanylate cyclase associated with adult respiratory distress syndrome
18) Confidence 0.05 Published 2001 Journal Crit Care Section Body Doc Link PMC31579 Disease Relevance 1.48 Pain Relevance 0
NO produced by NOS type III in the endothelium diffuses to the vascular smooth muscle (VSM) where it activates the enzyme guanylate cyclase.
Positive_regulation (activates) of guanylate cyclase in VSM
19) Confidence 0.04 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.46 Pain Relevance 0.03
Those investigators also showed that soluble guanylate cyclase could be activated by NO [12] and agreed with Murad's theory that NO could be the mediator of the action of nitrovasodilators on vascular smooth muscle.
Neg (NO) Positive_regulation (activated) of guanylate cyclase in smooth muscle
20) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 0.17 Pain Relevance 0.06

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