INT11065

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Context Info
Confidence 0.55
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.41
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NPR1)
Anatomy Link Frequency
spinal cord 2
plasma 1
NPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 3 100.00 Very High Very High Very High
Spinal cord 10 99.36 Very High Very High Very High
Thermal hyperalgesia 4 97.04 Very High Very High Very High
nMDA receptor 4 96.76 Very High Very High Very High
Lasting pain 4 95.72 Very High Very High Very High
anesthesia 2 95.60 Very High Very High Very High
withdrawal 2 95.20 Very High Very High Very High
Neurotransmitter 2 83.92 Quite High
Pain 2 77.36 Quite High
analgesia 2 76.64 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 21 100.00 Very High Very High Very High
Diuresis 8 98.70 Very High Very High Very High
Hyperalgesia 4 97.04 Very High Very High Very High
Leukemia 1 95.40 Very High Very High Very High
Pain 6 95.28 Very High Very High Very High
Heart Rate Under Development 2 93.28 High High
Nociception 6 86.64 High High
Cv Unclassified Under Development 1 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This diuresis failed to correspond temporally with alterations noted in serum levels of atrial natriuretic peptide, renin, angiotensin, aldosterone, and vasopressin.
Gene_expression (levels) of atrial natriuretic peptide associated with natriuresis and diuresis
1) Confidence 0.55 Published 1992 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 1534591 Disease Relevance 0.92 Pain Relevance 0.08
The effect of two analogues of [Met]-enkephalin, [D-Ala2,N-Phe4,Met(0)-ol5]-enkephalin and its guanyl derivative, on plasma concentrations of atrial natriuretic peptide (ANP) and serum aldosterone in six normal subjects was investigated.
Spec (investigated) Gene_expression (effect) of atrial natriuretic peptide in plasma associated with natriuresis and enkephalin
2) Confidence 0.49 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 2965206 Disease Relevance 0.25 Pain Relevance 0.30
Serum levels of atrial natriuretic peptide were found to be significantly elevated immediately after discontinuation of cardiopulmonary bypass.
Gene_expression (levels) of atrial natriuretic peptide associated with natriuresis
3) Confidence 0.48 Published 1992 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 1534591 Disease Relevance 0.88 Pain Relevance 0.10
METHODS: Experimental conditions for HS-SPME and GC-MS were systematically optimized to produce the sensitive analytical method reported.
Gene_expression (produce) of GC-MS
4) Confidence 0.33 Published 2010 Journal Forensic Sci. Int. Section Body Doc Link 20083362 Disease Relevance 0 Pain Relevance 0
This enzyme is involved in the inactivation of regulatory peptides such as enkephalins and atrial natriuretic peptide and its expression on the cell surface is therefore essential.
Gene_expression (expression) of atrial natriuretic peptide associated with natriuresis and enkephalin
5) Confidence 0.13 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1533518 Disease Relevance 0.20 Pain Relevance 0.10
Collectively, these reports suggest that the reflex withdrawal response to noxious heat is not mediated through activation of NMDA receptors and subsequent production of NO and cGMP, but that the acute NMDA-produced facilitation of thermal reflexes is NMDA-, NO- and cGMP-mediated and that a sustained production of NO and subsequent activation of soluble guanylate cyclase (GC-S) in the lumbar spinal cord appears to be required for maintenance of the thermal hyperalgesia produced in persistent pain models.
Gene_expression (production) of GC-S in spinal cord associated with pain, lasting pain, thermal hyperalgesia, nmda receptor, withdrawal and spinal cord
6) Confidence 0.02 Published 1993 Journal Pain Section Abstract Doc Link 8455960 Disease Relevance 0.58 Pain Relevance 0.87
Collectively, these reports suggest that the reflex withdrawal response to noxious heat is not mediated through activation of NMDA receptors and subsequent production of NO and cGMP, but that the acute NMDA-produced facilitation of thermal reflexes is NMDA-, NO- and cGMP-mediated and that a sustained production of NO and subsequent activation of soluble guanylate cyclase (GC-S) in the lumbar spinal cord appears to be required for maintenance of the thermal hyperalgesia produced in persistent pain models.
Gene_expression (production) of cyclase in spinal cord associated with pain, lasting pain, thermal hyperalgesia, nmda receptor, withdrawal and spinal cord
7) Confidence 0.02 Published 1993 Journal Pain Section Abstract Doc Link 8455960 Disease Relevance 0.58 Pain Relevance 0.87

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