INT110666

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 5.67
Pain Relevance 5.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
neuronal 2
DRG 2
spinal 1
RVM 1
brain 1
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 16 100.00 Very High Very High Very High
Central grey 4 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
Spinal cord 3 99.92 Very High Very High Very High
dorsal root ganglion 19 99.84 Very High Very High Very High
Rostral ventromedial medulla 7 99.84 Very High Very High Very High
Morphine 8 99.82 Very High Very High Very High
Stimulus evoked pain 1 99.58 Very High Very High Very High
allodynia 2 99.50 Very High Very High Very High
narcan 2 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 100.00 Very High Very High Very High
Ganglion Cysts 27 99.84 Very High Very High Very High
Hypersensitivity 7 99.58 Very High Very High Very High
Neuropathic Pain 3 99.50 Very High Very High Very High
Pain 10 99.24 Very High Very High Very High
INFLAMMATION 13 98.48 Very High Very High Very High
Hypoxia 51 98.12 Very High Very High Very High
Neurodegenerative Disease 26 95.12 Very High Very High Very High
Injury 19 89.88 High High
Bordatella Infection 1 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The BDNF-responsive TrkB (Tropomyosin-associated kinase) receptors upregulate or downregulate many second messengers that lead to the phosphorylation of transcriptional factors such as CREB (c-AMP response element-binding).
Phosphorylation (phosphorylation) of BDNF
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.74 Pain Relevance 0.39
Here we found that, in cultured rat cortical neurons, bidirectional changes of neuronal activity led to corresponding alterations in the expression of brain-derived neurotrophic factor (BDNF) and phosphorylation of its receptor tropomyosin-related kinase B (TrkB), as well as in the level of synaptic proteins.
Phosphorylation (phosphorylation) of brain-derived neurotrophic factor in neuronal
2) Confidence 0.54 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18474605 Disease Relevance 0 Pain Relevance 0.07
Here we found that, in cultured rat cortical neurons, bidirectional changes of neuronal activity led to corresponding alterations in the expression of brain-derived neurotrophic factor (BDNF) and phosphorylation of its receptor tropomyosin-related kinase B (TrkB), as well as in the level of synaptic proteins.
Phosphorylation (phosphorylation) of BDNF in neuronal
3) Confidence 0.54 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18474605 Disease Relevance 0 Pain Relevance 0.07
Brain-derived neurotrophic factor-elicited or sciatic ligation-associated phosphorylation of cyclic AMP response element binding protein in the rat spinal dorsal horn is reduced by block of tyrosine kinase receptors.
Phosphorylation (phosphorylation) of Brain-derived neurotrophic factor in spinal associated with neuralgia and spinal dorsal horn
4) Confidence 0.54 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15135945 Disease Relevance 0.18 Pain Relevance 0.48
M NMDA and 50 ng/ml BDNF, at different incubation times. b Effect of various signalling pathway inhibitors on GSK3 phosphorylation.
Phosphorylation (phosphorylation) of BDNF
5) Confidence 0.44 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.06
Previous studies have shown that several DNA-binding transcription factors are phosphorylated in a BDNF-dependent manner and that their activities are required for BDNF-induced gene expression [14], [32].
Phosphorylation (phosphorylated) of BDNF
6) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.08 Pain Relevance 0
Lithium antagonizes phosphorylated CREB loss and upregulates both CREB and BDNF in several brain regions [118].
Phosphorylation (phosphorylated) of BDNF in brain associated with bdmf
7) Confidence 0.34 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.21 Pain Relevance 0.29
BDNF in PAG and TrkB phosphorylation in RVM neurons are upregulated after inflammation.
Phosphorylation (phosphorylation) of BDNF in RVM associated with inflammation, central grey and rostral ventromedial medulla
8) Confidence 0.31 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16399679 Disease Relevance 0.97 Pain Relevance 1.05
BDNF completely blocked the phosphorylation of ERKs for 6 hours, but it had no effect thereafter.
Phosphorylation (phosphorylation) of BDNF
9) Confidence 0.20 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.75 Pain Relevance 0
Morphine induced BDNF gene expression and ERK1/2 (extracellular signal-regulated kinase 1/2) phosphorylation, and these were abolishable by naloxone, wortmannin, PD98059, genistein, and 1,10-phenanthroline.
Phosphorylation (phosphorylation) of BDNF associated with narcan and morphine
10) Confidence 0.18 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647486 Disease Relevance 0.09 Pain Relevance 0.80
The treatment of the mitogen-activated protein kinase (MAPK) kinase 1/2 inhibitor U0126 reversed the pain hypersensitivity and the increase in phosphorylated-ERK (p-ERK) and BDNF in DRG neurons induced by complete Freund's adjuvant.
Phosphorylation (phosphorylated-ERK) of BDNF in DRG associated with dorsal root ganglion, hypersensitivity and stimulus evoked pain
11) Confidence 0.17 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764099 Disease Relevance 1.03 Pain Relevance 0.67
Furthermore, we found that nerve growth factor (NGF) injection directly into the L4/5 nerve roots and DRG produced mechanical allodynia, and an increase in the phosphorylation of ERK and BDNF expression in the DRG, but the mitogen-activated protein kinase (MAPK) kinase1/2 inhibitor, U0126, inhibited the effects induced by NGF.
Phosphorylation (phosphorylation) of BDNF in DRG associated with dorsal root ganglion, allodynia and nerve growth factor
12) Confidence 0.09 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207334 Disease Relevance 1.61 Pain Relevance 1.32

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