INT11069

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Context Info
Confidence 0.68
First Reported 1981
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 35
Total Number 37
Disease Relevance 27.70
Pain Relevance 13.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pf4) extracellular region (Pf4) protein complex assembly (Pf4)
molecular_function (Pf4) protein complex (Pf4)
Anatomy Link Frequency
platelet 18
plasma 9
blood 4
muscle 2
Pf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 49 99.84 Very High Very High Very High
Pain 41 99.84 Very High Very High Very High
Migraine 41 99.52 Very High Very High Very High
Angina 69 99.28 Very High Very High Very High
aspirin 24 99.18 Very High Very High Very High
Serotonin 13 98.92 Very High Very High Very High
Cluster headache 5 96.56 Very High Very High Very High
imagery 1 89.16 High High
antagonist 11 86.52 High High
cva 13 85.92 High High
Disease Link Frequency Relevance Heat
Headache 76 99.84 Very High Very High Very High
Myocardial Infarction 31 99.84 Very High Very High Very High
Cardiovascular Disease 17 99.60 Very High Very High Very High
Infarction 26 99.56 Very High Very High Very High
Angina 34 99.28 Very High Very High Very High
Coronary Artery Disease 26 98.96 Very High Very High Very High
Coagulation Disorder 3 98.54 Very High Very High Very High
Myelodysplastic Syndromes 28 98.46 Very High Very High Very High
Cv General 3 Under Development 39 98.36 Very High Very High Very High
Thrombocytosis 20 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results confirmed an increase in beta-TG and PF4 levels and a reduction in serotonin levels during the migraine attacks.
Positive_regulation (increase) of PF4 associated with migraine and serotonin
1) Confidence 0.68 Published 1991 Journal Neurologia Section Abstract Doc Link 1830748 Disease Relevance 0.36 Pain Relevance 0.63
There was a significant increase in plasma PF4 concentrations in patients with documented coronary artery disease compared with angiographically normal patients (8.7 vs 16 ng/ml, respectively, n = 121), but as in previous studies of platelet survival, we could not correlate elevated plasma PF4 concentration and the severity or site of the coronary artery disease.
Positive_regulation (increase) of PF4 in plasma associated with coronary artery disease
2) Confidence 0.56 Published 1981 Journal Circulation Section Abstract Doc Link 6973419 Disease Relevance 0.77 Pain Relevance 0.12
The results indicated that statistically significantly higher levels of beta-TG and PF4 occur in the patients during the remission period when compared with the control subjects.
Positive_regulation (levels) of PF4
3) Confidence 0.49 Published 1986 Journal Cephalalgia Section Abstract Doc Link 2945644 Disease Relevance 0.68 Pain Relevance 0.68
Administration of aspirin (ASA) was more effective than flunarizine in inducing a decrease in beta-TG and PF4 plasma levels in migraineurs.
Positive_regulation (inducing) of PF4 in plasma associated with aspirin
4) Confidence 0.48 Published 1985 Journal Cephalalgia Section Abstract Doc Link 3160472 Disease Relevance 0.89 Pain Relevance 0.90
Thrombocythemia (ET and PV) patients with microvascular disturbances have shortened platelet survival, increased beta-thromboglobulin (beta-tg), platelet factor 4 (PF4), and thrombomoduline (TM) levels, and increased urinary thromboxane B2 (TxB2) excretion indicating platelet-mediated processes in vivo.
Positive_regulation (increased) of PF4 in platelet associated with thrombocytosis and myelodysplastic syndromes
5) Confidence 0.45 Published 2006 Journal Platelets Section Abstract Doc Link 17127481 Disease Relevance 1.40 Pain Relevance 0.21
We investigated plasma beta-thromboglobulin (BTG), platelet factor 4 (PF4), and 5-hydroxytryptamine (5-HT) in migraine patients and muscle contraction headache (MCH) patients during headache-free periods.
Spec (investigated) Positive_regulation (investigated) of PF4 in muscle associated with migraine and headache
6) Confidence 0.45 Published 1987 Journal Cephalalgia Section Abstract Doc Link 2962739 Disease Relevance 1.05 Pain Relevance 1.05
We investigated plasma beta-thromboglobulin (BTG), platelet factor 4 (PF4), and 5-hydroxytryptamine (5-HT) in migraine patients and muscle contraction headache (MCH) patients during headache-free periods.
Spec (investigated) Positive_regulation (investigated) of platelet factor 4 in muscle associated with migraine and headache
7) Confidence 0.45 Published 1987 Journal Cephalalgia Section Abstract Doc Link 2962739 Disease Relevance 1.04 Pain Relevance 1.04
Although increases of platelet factor IV have been observed in patients with infarction, the implication that they reflect pathogenetic phenomena such as coronary thrombosis has not been assessed explicitly.
Positive_regulation (increases) of platelet factor IV in platelet associated with thrombosis related under development and infarction
8) Confidence 0.43 Published 1984 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 6237142 Disease Relevance 0.48 Pain Relevance 0
Lack of elevation of platelet factor IV in plasma from patients with myocardial infarction.
Positive_regulation (elevation) of platelet factor IV in plasma associated with pain and myocardial infarction
9) Confidence 0.43 Published 1984 Journal J. Am. Coll. Cardiol. Section Title Doc Link 6237142 Disease Relevance 0.63 Pain Relevance 0.15
On the other hand, the plasma levels of BTG and PF4 were increased in patients with variant angina as compared with those with stable exertional angina but did not show a significant circadian variation in both groups.
Positive_regulation (increased) of PF4 in plasma associated with angina
10) Confidence 0.40 Published 1989 Journal Circulation Section Abstract Doc Link 2532074 Disease Relevance 0.84 Pain Relevance 0.86
We conclude that 1) plasma levels of FPA, BTG, and PF4 were increased in patients with variant angina as compared with those with stable exertional angina; 2) there was a significant circadian variation in the plasma levels of FPA in parallel with that of the frequency of the attacks with the peak level occurring from midnight to early morning in patients with variant angina; and 3) elevated levels of plasma FPA are the result and not the cause of coronary spasm.
Positive_regulation (increased) of PF4 in plasma associated with angina and cva
11) Confidence 0.40 Published 1989 Journal Circulation Section Abstract Doc Link 2532074 Disease Relevance 0.94 Pain Relevance 0.90
There was a significant increase in plasma PF4 concentrations in patients with documented coronary artery disease compared with angiographically normal patients (8.7 vs 16 ng/ml, respectively, n = 121), but as in previous studies of platelet survival, we could not correlate elevated plasma PF4 concentration and the severity or site of the coronary artery disease.
Positive_regulation (elevated) of PF4 in plasma associated with coronary artery disease
12) Confidence 0.40 Published 1981 Journal Circulation Section Abstract Doc Link 6973419 Disease Relevance 0.95 Pain Relevance 0.28
Patients who were being treated with propranolol or one of the longer-acting beta-blocking agents did not have a significant increase in plasma PF4 following exercise, in contrast to patients who were not beta-blocked.
Positive_regulation (increase) of PF4 in plasma
13) Confidence 0.40 Published 1984 Journal Am. J. Hematol. Section Abstract Doc Link 6147087 Disease Relevance 0.36 Pain Relevance 0.12
Thrombocythemia (ET and PV) patients with microvascular disturbances have shortened platelet survival, increased beta-thromboglobulin (beta-tg), platelet factor 4 (PF4), and thrombomoduline (TM) levels, and increased urinary thromboxane B2 (TxB2) excretion indicating platelet-mediated processes in vivo.
Positive_regulation (increased) of platelet factor 4 in platelet associated with thrombocytosis and myelodysplastic syndromes
14) Confidence 0.39 Published 2006 Journal Platelets Section Abstract Doc Link 17127481 Disease Relevance 1.40 Pain Relevance 0.21
The increases of PF4 in MCH and migraine during this test were significantly greater than in healthy controls.
Positive_regulation (increases) of PF4 associated with migraine and headache
15) Confidence 0.36 Published 1989 Journal Cephalalgia Section Abstract Doc Link 2706677 Disease Relevance 1.02 Pain Relevance 1.05
The increase of PF4, however, was independent of NE increase and FFA changes.
Positive_regulation (increase) of PF4
16) Confidence 0.36 Published 1989 Journal Cephalalgia Section Abstract Doc Link 2706677 Disease Relevance 1.03 Pain Relevance 1.08
Clearance of platelet factor IV is much faster than that of beta-thromboglobulin after release of the proteins in vivo.
Positive_regulation (Clearance) of platelet factor IV in platelet
17) Confidence 0.31 Published 1984 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 6237142 Disease Relevance 0.42 Pain Relevance 0
In 19 patients with unstable angina pectoris at rest, plasma levels of the platelet-derived proteins beta-thromboglobulin and platelet factor 4 were significantly elevated in blood samples obtained during or within 4 hours after episodes of angina, but were usually normal during quiescent intervals.
Positive_regulation (elevated) of platelet factor 4 in platelet associated with angina
18) Confidence 0.30 Published 1981 Journal Circulation Section Abstract Doc Link 6450001 Disease Relevance 0.80 Pain Relevance 0.74
Platelet factor IV generally did not increase during hospitalization in patients with infarction despite recurrent chest pain, development of left ventricular thrombus or documented recurrent infarction.
Neg (not) Positive_regulation (increase) of Platelet factor IV in Platelet associated with angina, infarction and thrombosis
19) Confidence 0.29 Published 1984 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 6237142 Disease Relevance 1.20 Pain Relevance 0.19
Mean platelet factor 4(PF4) levels measured in 10 cases of each subgroup were significantly elevated in myocardial infarction (MI) (48.4 +/- 15.16 ng/ml) and III unstable angina patients (44.7 +/- 15.9 ng/ml) as compared to controls (25.42 +/- 12.47 ng/ml; P less than 0.01).
Positive_regulation (elevated) of PF4 in platelet associated with angina and myocardial infarction
20) Confidence 0.27 Published 1990 Journal Indian Heart J Section Abstract Doc Link 1711506 Disease Relevance 0.91 Pain Relevance 0.33

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