INT110735

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.19
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm8) signal transducer activity (Grm8)
Anatomy Link Frequency
spike 2
midbrain 2
neurons 1
brain 1
Grm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 10 100.00 Very High Very High Very High
amygdala 68 99.98 Very High Very High Very High
GABAergic 7 99.84 Very High Very High Very High
long-term potentiation 32 99.80 Very High Very High Very High
Pain 42 98.82 Very High Very High Very High
agonist 22 98.80 Very High Very High Very High
midbrain 2 98.76 Very High Very High Very High
Arthritis 14 98.72 Very High Very High Very High
Ventral tegmentum 3 98.40 Very High Very High Very High
Periaqueductal grey 6 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 42 98.82 Very High Very High Very High
Arthritis 37 98.72 Very High Very High Very High
Urological Neuroanatomy 8 98.28 Very High Very High Very High
Nociception 9 76.44 Quite High
Neurological Disease 1 73.24 Quite High
Anxiety Disorder 6 21.28 Low Low
Depression 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Low Back Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of metabotropic glutamate receptor (mGluR) activation on GABAergic synaptic transmission in rat periaqueductal grey (PAG) neurons was examined using whole-cell patch-clamp recordings in brain slices.
Spec (examined) Regulation (effect) of in neurons Spec (examined) Positive_regulation (activation) of mGluR in brain associated with periaqueductal grey, gabaergic and glutamate receptor
1) Confidence 0.40 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15081789 Disease Relevance 0.34 Pain Relevance 0.43
These results reveal a dual modulation of mGLuR activation on inhibitory transmission in midbrain ventral tegmental area: enhancing putative GABAergic neuronal excitability and thus potentiating tonic inhibitory synaptic transmission while reducing evoked synaptic transmission at inhibitory terminals.
Regulation (modulation) of Positive_regulation (activation) of mGLuR in midbrain associated with ventral tegmentum, neuronal excitability, gabaergic and midbrain
2) Confidence 0.26 Published 2003 Journal Neuroscience Section Abstract Doc Link 12770559 Disease Relevance 0 Pain Relevance 0.87
Our previous studies showed that arthritis pain-related sensitization and synaptic plasticity in the CeLC depend on presynaptic group I mGluR upregulation [19,21] and on postsynaptic N-methyl-D-aspartate (NMDA) receptor phosphorylation through the cAMP-dependent protein kinase PKA [20,22].
Regulation (depend) of Positive_regulation (upregulation) of mGluR associated with pain, amygdala and arthritis
3) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1471776 Disease Relevance 0.85 Pain Relevance 0.90
In the experiments presented here, we found the induction of LTP through natural spike trains to be independent of NMDAR and mGluR activation, as LTP could readily be induced in the presence of the respective receptor antagonists.
Neg (independent) Regulation (independent) of Positive_regulation (activation) of mGluR in spike associated with antagonist and long-term potentiation
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848597 Disease Relevance 0 Pain Relevance 0.42

General Comments

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