INT110738

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.44
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
amnion 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 23 100.00 Very High Very High Very High
Dismenorea 3 97.64 Very High Very High Very High
antagonist 9 50.00 Quite Low
cytokine 15 31.80 Quite Low
Facet joint 19 5.00 Very Low Very Low Very Low
Sciatica 14 5.00 Very Low Very Low Very Low
imagery 13 5.00 Very Low Very Low Very Low
Chronic low back pain 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 3 97.64 Very High Very High Very High
Intervertebral Disk Degeneration 34 92.92 High High
Rupture 2 70.20 Quite High
Apoptosis 5 21.36 Low Low
Nerve Root Compression 14 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Low Back Pain 8 5.00 Very Low Very Low Very Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, an increase in MMP-9 activity and a decrease in TIMP-1 protein levels were observed following the establishment of uterine contractions in media conditioned by amnion.
Positive_regulation (increase) of Negative_regulation (decrease) of TIMP-1 in amnion associated with dismenorea
1) Confidence 0.44 Published 2003 Journal Mol. Hum. Reprod. Section Abstract Doc Link 12771238 Disease Relevance 0.35 Pain Relevance 0.40
Wallach et al. also reported that gene transfer of the tissue inhibitor of metalloproteinase 1 (TIMP-1), an inhibitor of catabolic enzymes, can increase PG accumulation in pellet cultures of human IVD cells.71 This study introduced a new approach to modulate a course of disc degeneration by inhibiting the catabolic pathway rather than stimulating the anabolic pathway.
Positive_regulation (transfer) of Negative_regulation (inhibitor) of metalloproteinase 1 associated with intervertebral disk degeneration and metalloproteinase
2) Confidence 0.10 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.09 Pain Relevance 0.05
Here, PMSF caused a 35% reduction in collagenase and 22% reduction in gelatinase activity (p < 0.05 for both) and leupeptin a 21% reduction in collagenase activity (p < 0.05), indicating serine/cysteine protease activity in the AF.
Positive_regulation (caused) of Negative_regulation (reduction) of collagenase
3) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0
Here, PMSF caused a 35% reduction in collagenase and 22% reduction in gelatinase activity (p < 0.05 for both) and leupeptin a 21% reduction in collagenase activity (p < 0.05), indicating serine/cysteine protease activity in the AF.
Positive_regulation (caused) of Negative_regulation (reduction) of collagenase
4) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0

General Comments

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