INT110738

Context Info Confidence 0.44 First Reported 2003 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.44 Pain Relevance 0.45

aging (TIMP1) extracellular region (TIMP1)

Anatomy Link Frequency amnion 2 TIMP1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 23 100.00 Dismenorea 3 97.64 antagonist 9 50.00 cytokine 15 31.80 Facet joint 19 5.00 Sciatica 14 5.00 imagery 13 5.00 Chronic low back pain 4 5.00 Pain 4 5.00 backache 4 5.00

Disease Link Frequency Relevance Heat Dysmenorrhea 3 97.64 Intervertebral Disk Degeneration 34 92.92 Rupture 2 70.20 Apoptosis 5 21.36 Nerve Root Compression 14 5.00 Disease 12 5.00 Low Back Pain 8 5.00 Osteoarthritis 8 5.00 Pressure And Volume Under Development 6 5.00 Pain 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, an increase in MMP-9 activity and a decrease in TIMP-1 protein levels were observed following the establishment of uterine contractions in media conditioned by amnion.

Positive_regulation (increase) of Negative_regulation (decrease) of TIMP-1 in amnion associated with dismenorea

1) Confidence 0.44 Published 2003 Journal Mol. Hum. Reprod. Section Abstract Doc Link 12771238 Disease Relevance 0.35 Pain Relevance 0.40

Wallach et al. also reported that gene transfer of the tissue inhibitor of metalloproteinase 1 (TIMP-1), an inhibitor of catabolic enzymes, can increase PG accumulation in pellet cultures of human IVD cells.71 This study introduced a new approach to modulate a course of disc degeneration by inhibiting the catabolic pathway rather than stimulating the anabolic pathway.

Positive_regulation (transfer) of Negative_regulation (inhibitor) of metalloproteinase 1 associated with intervertebral disk degeneration and metalloproteinase

2) Confidence 0.10 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.09 Pain Relevance 0.05

Here, PMSF caused a 35% reduction in collagenase and 22% reduction in gelatinase activity (p < 0.05 for both) and leupeptin a 21% reduction in collagenase activity (p < 0.05), indicating serine/cysteine protease activity in the AF.

Positive_regulation (caused) of Negative_regulation (reduction) of collagenase

3) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0

Here, PMSF caused a 35% reduction in collagenase and 22% reduction in gelatinase activity (p < 0.05 for both) and leupeptin a 21% reduction in collagenase activity (p < 0.05), indicating serine/cysteine protease activity in the AF.

Positive_regulation (caused) of Negative_regulation (reduction) of collagenase

4) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0

General Comments

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