INT110739

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.29
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
liver 4
decidua 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 15 100.00 Very High Very High Very High
Dismenorea 3 98.32 Very High Very High Very High
fibrosis 38 93.56 High High
Inflammation 96 77.92 Quite High
cINOD 5 75.00 Quite High
antagonist 4 50.00 Quite Low
cytokine 47 31.28 Quite Low
Inflammatory response 22 19.68 Low Low
chemokine 12 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 111 99.74 Very High Very High Very High
Injury 92 98.80 Very High Very High Very High
Dysmenorrhea 3 98.32 Very High Very High Very High
Fibrosis 74 98.00 Very High Very High Very High
Cirrhosis 90 94.32 High High
Death 111 89.92 High High
Stress 214 88.80 High High
Rupture 2 82.28 Quite High
INFLAMMATION 116 77.92 Quite High
Colon Cancer 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that in media conditioned by decidua, following the establishment of uterine contractions, matrix metalloproteinase-2 (MMP-2) activity is increased while the protein tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) level is decreased.
Negative_regulation (decreased) of Negative_regulation (inhibitors) of TIMP-1 in decidua associated with metalloproteinase and dismenorea
1) Confidence 0.41 Published 2003 Journal Mol. Hum. Reprod. Section Abstract Doc Link 12771238 Disease Relevance 0.34 Pain Relevance 0.40
Furthermore, flurbiprofen was shown to induce the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of TIMP-1 associated with metalloproteinase
2) Confidence 0.36 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.33 Pain Relevance 0.28
Recovery from either acute or chronic liver injury in animal models is characterized by apoptosis of HSC/MFs, reduction of TIMP (tissue inhibitor of metalloproteinases) levels and progressive degradation of fibrillar fibrotic ECM.
Negative_regulation (reduction) of Negative_regulation (inhibitor) of metalloproteinases in liver associated with fibrosis, injury, metalloproteinase and apoptosis
3) Confidence 0.17 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.31 Pain Relevance 0.14
Recovery from either acute or chronic liver injury in animal models is characterized by apoptosis of HSC/MFs, reduction of TIMP (tissue inhibitor of metalloproteinases) levels and progressive degradation of fibrillar fibrotic ECM.
Negative_regulation (reduction) of Negative_regulation (reduction) of TIMP in liver associated with fibrosis, injury, metalloproteinase and apoptosis
4) Confidence 0.17 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.30 Pain Relevance 0.14
Here, PMSF caused a 35% reduction in collagenase and 22% reduction in gelatinase activity (p < 0.05 for both) and leupeptin a 21% reduction in collagenase activity (p < 0.05), indicating serine/cysteine protease activity in the AF.
Negative_regulation (reduction) of Negative_regulation (reduction) of collagenase
5) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0

General Comments

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