INT110748

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.06
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tenc1)
Anatomy Link Frequency
brain 2
uterus 1
plaque 1
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 4 99.68 Very High Very High Very High
substance P 7 90.20 High High
isoflurane 1 74.56 Quite High
anesthesia 4 71.80 Quite High
Neuropeptide 2 57.88 Quite High
Cholecystokinin 1 55.48 Quite High
Enkephalin 3 54.64 Quite High
metalloproteinase 40 50.00 Quite Low
qutenza 2 48.08 Quite Low
antagonist 1 36.72 Quite Low
Disease Link Frequency Relevance Heat
Normal Pressure Hydrocephalus 48 100.00 Very High Very High Very High
Disease 198 99.78 Very High Very High Very High
Alzheimer's Dementia 66 99.32 Very High Very High Very High
Hydrocephalus 9 98.52 Very High Very High Very High
Amyloid Plaque 14 97.98 Very High Very High Very High
Cognitive Disorder 10 90.92 High High
Targeted Disruption 22 84.88 Quite High
Dementia 10 77.04 Quite High
Frailty 3 48.24 Quite Low
Leukemia 1 34.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such subjects were treated with the standard of care for NPH at the enrolling center, and at the discretion of the neurosurgeon, a conventional hydrocephalus shunt could be implanted
Transcription (discretion) of NPH associated with normal pressure hydrocephalus and hydrocephalus
1) Confidence 0.30 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 0.74 Pain Relevance 0.17
The mRNA of neprilysin (NEP), the main enzyme involved in tachykinin metabolism, was also expressed in the uterus.
Transcription (expressed) of NEP in uterus
2) Confidence 0.20 Published 2003 Journal Biol. Reprod. Section Abstract Doc Link 12773411 Disease Relevance 0 Pain Relevance 0.05
NEP mRNA levels were reduced in amyloid affected areas of sporadic AD brain, which could be the cause of A?
Transcription (levels) of NEP in brain associated with alzheimer's dementia and disease
3) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.72 Pain Relevance 0
In human postmortem brain samples an increased amyloid plaque density is associated with decreased NEP immunoreactivity [109], and, in the brains of AD patients, NEP mRNA levels in the hippocampus and temporal gyrus were lower than those in the same regions of control brains [110].
Transcription (levels) of NEP in brains associated with hippocampus, disease and amyloid plaque
4) Confidence 0.09 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.78 Pain Relevance 0.21
Similarly, by western blot and by PCR experiments using reverse transcriptase, NEP protein and mRNA levels, respectively, were found to be lowest in AD patients in the hippocampus and temporal gyrus, two areas that are vulnerable to senile plaque development, and found to be highest in caudate and peripheral organs which are resistant to A?
Transcription (levels) of NEP in plaque associated with hippocampus, disease and amyloid plaque
5) Confidence 0.06 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2726140 Disease Relevance 0.82 Pain Relevance 0.05

General Comments

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