INT110767

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 24.30
Pain Relevance 16.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
macrophages 3
microglia 2
plasma 1
ventricle 1
retina 1
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 930 100.00 Very High Very High Very High
Inflammation 811 100.00 Very High Very High Very High
chemokine 217 100.00 Very High Very High Very High
Inflammatory mediators 50 100.00 Very High Very High Very High
Morphine 702 99.84 Very High Very High Very High
substance P 4 99.82 Very High Very High Very High
metalloproteinase 51 99.60 Very High Very High Very High
Potency 24 99.52 Very High Very High Very High
ischemia 42 99.26 Very High Very High Very High
qutenza 16 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 982 100.00 Very High Very High Very High
Obesity 147 99.98 Very High Very High Very High
Cirrhosis 25 99.98 Very High Very High Very High
Adhesions 56 99.88 Very High Very High Very High
Rheumatoid Arthritis 200 99.82 Very High Very High Very High
Cv Unclassified Under Development 63 99.26 Very High Very High Very High
Wound Healing 35 99.04 Very High Very High Very High
Targeted Disruption 80 98.64 Very High Very High Very High
Insulin Resistance 25 98.24 Very High Very High Very High
Infection 75 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.
Localization (release) of MCP-1 in adipocytes associated with qutenza and obesity
1) Confidence 0.68 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.22 Pain Relevance 0.66
The attenuation of leukocyte recruitment might lead to the reduction of secretion of IL-6 and MCP-1.
Localization (secretion) of MCP-1 in leukocyte
2) Confidence 0.61 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.85 Pain Relevance 0.26
When splenocytes were isolated from respective groups and cultured in the presence of OVA, cells from PG102-administrated animals produced lesser amounts of IL-6 and MCP-1.
Localization (amounts) of MCP-1
3) Confidence 0.56 Published 2009 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 19439982 Disease Relevance 0.38 Pain Relevance 0
and MCP-1 may occur via an A?
Localization (occur) of MCP-1
4) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.53 Pain Relevance 0.24
On the other hand, Rx had a more effective inhibitory effect than Rosiglitazone on the secretion of MCP-1 and IL-6 (figure 3a, b).
Localization (secretion) of MCP-1
5) Confidence 0.33 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.31 Pain Relevance 0.23
The cytokine-stimulated adipocytes secrete chemokines such as MCP-1 which further enhance the recruitment of macrophages into the adipose tissue, hence amplifying the inflammatory response [21-23].
Localization (secrete) of MCP-1 in macrophages associated with chemokine, inflammatory response, obesity and cytokine
6) Confidence 0.33 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 1.99 Pain Relevance 0.44
Measurement of MCP-1, ICAM-1, MMP-9 and oxLDL
Localization (Measurement) of MCP-1 associated with metalloproteinase
7) Confidence 0.31 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.09 Pain Relevance 0.08
Treatment with the selected active fraction Rx caused a drastic reduction in secretion of pro-inflammatory cytokines including MCP-1 and IL-6 in the conditioned medium of THP-1 macrophages, in a dose-dependent manner (figure 3a, b).
Localization (secretion) of MCP-1 in macrophages associated with inflammation and cytokine
8) Confidence 0.30 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.39 Pain Relevance 0.35
, MCP-1 and IL10 release was significantly reduced in PTPH1-KO plasma compared to WTs 30 and 60 minutes post challenge.
Localization (release) of MCP-1 in plasma
9) Confidence 0.30 Published 2010 Journal J Inflamm (Lond) Section Abstract Doc Link PMC2873500 Disease Relevance 0.69 Pain Relevance 0.68
Levels of IL-6 and MCP-1 secretion following IgE-induced degranulation were further increased in Il10?
Localization (secretion) of MCP-1
10) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923184 Disease Relevance 0.53 Pain Relevance 0.14
Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.
Localization (release) of MCP-1 in adipose tissues associated with qutenza and obesity
11) Confidence 0.23 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.22 Pain Relevance 0.66
In NHBE cells, high levels of PDE4B, 4D and 7A mRNA inhibition were correlated with reduced functional activity, as illustrated by dose-dependent inhibition of IL-8 and MCP-1 secretion.
Localization (secretion) of MCP-1
12) Confidence 0.19 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.47 Pain Relevance 0.17
The strong inhibitory activity of combined 4B/4D and 7A AONs on IL-8 and MCP-1 secretion is in line with their ability to knock down their respective target mRNA (Figure 1).


Localization (secretion) of MCP-1 associated with targeted disruption
13) Confidence 0.19 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.45 Pain Relevance 0.16
As we did not detect clear cell infiltration, MCP-1 detected in the retina was likely released from RPE cells.
Localization (released) of MCP-1 in retina
14) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 0.54 Pain Relevance 0.27
When used in combination, PDE4B/4D and 7A AONs significantly abrogated the cytokine-induced secretion of IL-8 and MCP-1 to near baseline levels.
Localization (secretion) of MCP-1 associated with cytokine
15) Confidence 0.17 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2696437 Disease Relevance 0.43 Pain Relevance 0.35
Results indicate that the secretion of both IL-8 (Figure 2A) and MCP-1 (Figure 2B) were dose-dependently reduced by transfection with combined 4B/4D and 7A AONs.
Localization (secretion) of MCP-1
16) Confidence 0.17 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.29 Pain Relevance 0.12
Following kidney ischemia-perfusion, resident dentritic cells release TNF, IL-6, MCP-1, and RANTES and the depletion of DCs before ischemic injury significantly reduces TNF levels in the kidney [131].
Localization (release) of MCP-1 in kidney associated with ischemia and injury
17) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.64 Pain Relevance 0.16
Furthermore, the release of MCP-1 and IL-6 is highly calcium-dependent.
Localization (release) of MCP-1
18) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.81
Interestingly, we previously found that morphine could exacerbate Tat-induced increases in the release of RANTES and MCP-1, but not TNF-?
Localization (release) of MCP-1 associated with morphine
19) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.09 Pain Relevance 0.36
MCP-1 mRNA was normalized to 18S mRNA.
Localization (normalized) of MCP-1
20) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0

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