INT110768

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.66
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
retinas 1
bladders 1
Lung 1
A549 1
microglia 1
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 216 100.00 Very High Very High Very High
chemokine 50 100.00 Very High Very High Very High
cytokine 134 99.84 Very High Very High Very High
Eae 6 99.68 Very High Very High Very High
Thermal hyperalgesia 1 99.64 Very High Very High Very High
Nerve growth factor 9 97.52 Very High Very High Very High
Paracetamol 9 96.48 Very High Very High Very High
Angina 11 94.80 High High
Inflammatory response 32 91.76 High High
ischemia 3 90.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 244 100.00 Very High Very High Very High
Injury 14 99.68 Very High Very High Very High
Hyperalgesia 1 99.64 Very High Very High Very High
Hypoxia 87 97.32 Very High Very High Very High
Pulmonary Disease 23 97.00 Very High Very High Very High
Apoptosis 17 95.00 High High
Cv General 3 Under Development 11 94.80 High High
Hepatotoxicity 2 94.28 High High
Retina Disease 4 93.72 High High
Ocular & Orbital Inflammation 12 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B activation, which regulates IL-6 and MCP-1 transcription.
Transcription (transcription) of MCP-1
1) Confidence 0.52 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.83 Pain Relevance 0.26
However, mRNA levels for MCP-1 were increased fivefold following 15 weeks of treatment with Celecoxib in comparison to non-treated control mice.
Transcription (levels) of MCP-1
2) Confidence 0.26 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 14522423 Disease Relevance 0.05 Pain Relevance 0
Interestingly, T cell deficiency was associated with less thermal hyperalgesia and reduced mRNA levels for the macrophage marker molecule F4/80 and the chemokine macrophage chemoattractant protein-1 (MCP-1) after CCI.
Transcription (levels) of MCP-1 in F4/80 associated with chemokine, eae and thermal hyperalgesia
3) Confidence 0.23 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16674943 Disease Relevance 0.98 Pain Relevance 0.83
The mean levels of mRNA for CD44, VCAM-1, MCP-1, and Cox-2, in fact, were elevated in 6-weeks old apoE?
Transcription (levels) of MCP-1
4) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.46 Pain Relevance 0.04
The impact of these compounds on mRNA expression of GPX, TNF-alpha, and MCP-1 indicated that these compounds could act at a transcription level.
Transcription (expression) of MCP-1
5) Confidence 0.18 Published 2009 Journal J. Food Sci. Section Abstract Doc Link 19799668 Disease Relevance 0.44 Pain Relevance 0.58
The normal bladders expressed a basal level of MCP-1 and IL-6 mRNAs but not IFN-?
Transcription (expressed) of MCP-1 in bladders
6) Confidence 0.18 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2989383 Disease Relevance 0.77 Pain Relevance 0.28
Another study reported, in support of our observations, that selective pharmacological inhibition of COX-2 with NS-398 increases the transcription of inflammatory genes (mPGES-1, TLR2, CD14, MCP-1) in vascular associated brain cells and parenchymal microglia after systemic injection of LPS [14].
Transcription (transcription) of MCP-1 in microglia associated with inflammation
7) Confidence 0.16 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.90 Pain Relevance 0.36
Lung mRNA levels of the inflammatory biomarkers VCAM-1, ICAM-1, and MCP-1, as well as of endothelin-1 (ET-1) were considerably higher after hypoxia than after normoxia, with no differences between IL-6-/- and wild-type mice (Figure 5).


Transcription (levels) of MCP-1 in Lung associated with inflammation and hypoxia
8) Confidence 0.15 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.93 Pain Relevance 0.09
A transient increase of MCP-1 protein and mRNA at PI-1 was detected in the retinas following subretinal injection.
Transcription (detected) of MCP-1 protein in retinas
9) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 0.63 Pain Relevance 0.19
release, but only partially inhibited IL-6 and MCP-1 mRNA levels, suggesting the possibility that TNF-?
Transcription (levels) of MCP-1
10) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.05 Pain Relevance 0.51
Studies by Momoi's group [20] have demonstrated TZD's ability to inhibit MCP-1 protein and mRNA expression in cytokine-treated A549 lung epithelial cells.
Transcription (expression) of MCP-1 in A549 associated with cytokine
11) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 0.47 Pain Relevance 0.38
IL-1beta and MCP-1 mRNAs were nearly undetectable.
Transcription (undetectable) of MCP-1
12) Confidence 0.02 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12775581 Disease Relevance 1.15 Pain Relevance 1.19

General Comments

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