INT11077

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 6
Speculated 3
Reported most in Abstract
Documents 63
Total Number 67
Disease Relevance 15.61
Pain Relevance 22.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr3a) cytoplasm (Htr3a)
Anatomy Link Frequency
cortex 2
spinal cord 2
stomach fundus 2
nerve 2
visceral 1
Htr3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 123 100.00 Very High Very High Very High
Dopamine 45 100.00 Very High Very High Very High
gABA 20 100.00 Very High Very High Very High
Opioid 11 100.00 Very High Very High Very High
5HT 10 100.00 Very High Very High Very High
Paracetamol 3 100.00 Very High Very High Very High
Cholecystokinin 12 99.92 Very High Very High Very High
Mono iodoacetate 62 99.78 Very High Very High Very High
agonist 344 99.74 Very High Very High Very High
Lasting pain 15 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anaphylaxis 4 99.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 7 99.90 Very High Very High Very High
Stress 76 99.70 Very High Very High Very High
Pain 83 99.68 Very High Very High Very High
Nociception 19 99.62 Very High Very High Very High
Hypotension 7 99.30 Very High Very High Very High
Migraine Disorders 3 99.26 Very High Very High Very High
Neuropathic Pain 19 99.12 Very High Very High Very High
Ganglion Cysts 7 99.00 Very High Very High Very High
Abdominal Pain 7 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of 5-HT3 receptors in the NTS inhibits the cardiac Bezold-Jarisch reflex response.
Positive_regulation (Stimulation) of 5-HT3
1) Confidence 0.67 Published 1996 Journal Am. J. Physiol. Section Title Doc Link 8760161 Disease Relevance 0.18 Pain Relevance 0.30
These observations provide direct evidence that, in rat cortex, 5-HT modulates in-vivo release of ACh through activation of 5-HT3 receptors.
Positive_regulation (activation) of 5-HT3 in cortex
2) Confidence 0.67 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618425 Disease Relevance 0.35 Pain Relevance 0.33
These data suggest that 5-HT4 receptor activation enhances the ability of 5-HT3 receptor activation to induce intestinal allodynia.
Positive_regulation (activation) of 5-HT3 associated with allodynia
3) Confidence 0.67 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10471214 Disease Relevance 0.25 Pain Relevance 0.29
Phenylbiguanide, however, excited 20 of 23 neurones (87%), inhibited only one (4%) and had no effect on two indicating that 5-HT3 receptor activation has an excitatory action.
Positive_regulation (activation) of 5-HT3
4) Confidence 0.67 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225274 Disease Relevance 0 Pain Relevance 0.15
In conclusion, luminal stimuli induce 5-HT release, which in turn activates 5-HT3 receptors on mucosal vagal afferent terminals.
Positive_regulation (activates) of 5-HT3
5) Confidence 0.67 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11557511 Disease Relevance 0 Pain Relevance 0.25
These results suggest that 5-HT increases Isc through the 5-HT3 and 5-HT4 receptors, and that ramosetron is a potent and selective 5-HT3 receptor antagonist in rat colonic mucosa.
Positive_regulation (increases) of 5-HT3 associated with antagonist
6) Confidence 0.67 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9059853 Disease Relevance 0 Pain Relevance 0.25
The obtained results indicate that fluoxetine increases the MK-801-induced locomotor hyperactivity via activation of 5-HT3 receptors and, to a lesser degree, 5-HT2 ones.
Positive_regulation (activation) of 5-HT3 associated with attention deficit hyperactivity disorder and fluoxetine
7) Confidence 0.67 Published 1996 Journal J Neural Transm Section Abstract Doc Link 9026367 Disease Relevance 0.37 Pain Relevance 0.73
The results obtained indicate that: (a) activation of 5-HT1A receptors stimulated PRL secretion on day 16 and inhibited it on day 23; activation of 5-HT2 receptors stimulated PRL secretion on days 16 and 23, whereas activation of 5-HT3 receptors inhibited PRL release only on day 23; (b) activation of AMPA receptors inhibited PRL secretion on day 23, but not on day 16 and (c) a cross-talk is apparent between 5-HT2 and AMPA receptors in the regulation of PRL secretion, the stimulatory effect of DOI being blocked by AMPA.
Positive_regulation (activation) of 5-HT3
8) Confidence 0.67 Published 2001 Journal J. Physiol. Biochem. Section Abstract Doc Link 11800286 Disease Relevance 0 Pain Relevance 0.43
CONCLUSION: Intracerebroventricular morphine evokes spinal GABA release via the activation of 5-HT3 receptors in the spinal cord, resulting in antinociceptive effect.


Positive_regulation (activation) of 5-HT3 in spinal cord
9) Confidence 0.67 Published 2002 Journal Anesthesiology Section Body Doc Link 11981159 Disease Relevance 0 Pain Relevance 0
These studies suggest that descending pain inhibitory or facilitatory pathways from RVM act ultimately in the spinal cord in acute and chronic pain states through activation of 5-HT7 and 5-HT3 receptors, respectively.
Positive_regulation (activation) of 5-HT3 in RVM associated with pain, rostroventromedial medulla, lasting pain and spinal cord
10) Confidence 0.67 Published 2009 Journal Brain Res. Section Abstract Doc Link 19427839 Disease Relevance 0.83 Pain Relevance 1.65
Previous studies have shown that the activation of 5-HT3 receptors in the nucleus tractus solitarii (NTS) increases the baseline mean arterial pressure (MAP).
Positive_regulation (activation) of 5-HT3 in nucleus
11) Confidence 0.67 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12144032 Disease Relevance 0 Pain Relevance 0.32
The hypotensive response is due to a nonselective activation of 5-HT1 and 5-HT3 receptors through release of 5-HT.
Positive_regulation (activation) of 5-HT3 associated with hypotension
12) Confidence 0.67 Published 1995 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 8546536 Disease Relevance 0.40 Pain Relevance 0.28
Activation of 5-HT3 receptors was found to increase CCK release from rat cortical or nucleus accumbens synaptosomes.
Positive_regulation (Activation) of 5-HT3 in nucleus accumbens associated with nucleus accumbens and cholecystokinin
13) Confidence 0.67 Published 1993 Journal Neurochem. Int. Section Abstract Doc Link 8513278 Disease Relevance 0.42 Pain Relevance 1.07
Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons.
Positive_regulation (activation) of 5-HT3 in ganglion associated with ganglion cysts, cannabinoid and agonist
14) Confidence 0.67 Published 1995 Journal J. Neurophysiol. Section Title Doc Link 7760148 Disease Relevance 0.19 Pain Relevance 0.63
Intravenous injection of 5-HT3 receptor antagonist granisetron blocked c-fos expression in all brain nuclei examined, although intracerebroventricular injection of granisetron had no effect, suggesting that 5-HT released from the stomach may activate 5-HT3 receptors located in the peripheral vagal afferent nerve terminals and then induce brain c-fos expression. c-fos Positive cells in the NTS were labeled with retrograde tracer fluorogold injected in the PVN, suggesting that neurons in the NTS activated by gastric distension project axons to the PVN.
Spec (may) Positive_regulation (activate) of 5-HT3 in nerve associated with antagonist and intracerebroventricular
15) Confidence 0.67 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14684379 Disease Relevance 0 Pain Relevance 0.18
We conclude that the bradycardic and sympatho-inhibitory effects of quipazine result from activation of 5-HT3 receptors located in the cardiopulmonary area and of carotid body chemoreceptors.
Positive_regulation (activation) of 5-HT3 in carotid body
16) Confidence 0.67 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2120077 Disease Relevance 0.85 Pain Relevance 0
The modulation of acetylcholine (ACh) release by 5-HT3 receptor activation was studied using in vivo microdialysis.
Positive_regulation (activation) of 5-HT3
17) Confidence 0.67 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618425 Disease Relevance 0.12 Pain Relevance 0.14
Furthermore, postsynaptic 5HT receptor activation (not the 5HT2 receptor subtype) probably exerts a facilitatory effect while presynaptic 5HT1A receptor activation exerts an impairing effect on the memory consolidation process, probably due to autoreceptor inhibition of 5HT release.
Positive_regulation (activation) of 5HT1A receptor associated with 5ht
18) Confidence 0.50 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1534416 Disease Relevance 0 Pain Relevance 0.40
The data suggest that enhancement of serotonergic activity, particularly through 5-HT2 and 5-HT3 receptors, have therapeutic potential for the treatment of posthypoxic myoclonus.
Positive_regulation (enhancement) of 5-HT3 associated with myoclonus
19) Confidence 0.49 Published 1995 Journal Mov. Disord. Section Abstract Doc Link 8552114 Disease Relevance 0.37 Pain Relevance 0.48
The results suggest that in this cortical area 5-HT activates 5-HT3 receptors located on GABAergic neurons which in turn inhibit cholinergic function.
Positive_regulation (activates) of 5-HT3 in GABAergic neurons associated with gabaergic
20) Confidence 0.49 Published 1996 Journal Brain Res. Section Abstract Doc Link 8814902 Disease Relevance 0 Pain Relevance 0.31

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