INT110780

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Context Info
Confidence 0.06
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.47
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 1
cleavage 1
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 43 98.94 Very High Very High Very High
Abeta 1 95.72 Very High Very High Very High
Inflammatory response 14 47.12 Quite Low
agonist 2 23.68 Low Low
Inflammation 43 20.88 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 82 88.64 High High
INFLAMMATION 62 86.28 High High
Alzheimer's Dementia 10 75.00 Quite High
Targeted Disruption 18 60.60 Quite High
Amyloid Plaque 11 40.08 Quite Low
Dementia 14 5.00 Very Low Very Low Very Low
Cognitive Disorder 13 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 8 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to gamma-secretase inhibitors, Abeta42-lowering NSAIDs do not impair S3 cleavage in the NOTCH receptor and release of the NOTCH intracellular domain, a finding with conceptual implications for the development of safer drugs targeting Abeta production through gamma-secretase modulation.
Localization (release) of NOTCH in cleavage associated with cinod and abeta
1) Confidence 0.06 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12777371 Disease Relevance 0.32 Pain Relevance 0.55
-cleavage of APP, Notch and ErbB4.
Localization (cleavage) of Notch in Notch
2) Confidence 0.05 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.14 Pain Relevance 0.64

General Comments

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